DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Serpinb2 and Spn42Dd

DIOPT Version :9

Sequence 1:	NP_001167641.1	Gene:	Serpinb2 / 18788	MGIID:	97609	Length:	415	Species:	Mus musculus
Sequence 2:	NP_001163067.1	Gene:	Spn42Dd / 49808	FlyBaseID:	FBgn0028988	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	414	Identity:	127/414 - (30%)
Similarity:	209/414 - (50%)	Gaps:	59/414 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 TMFALNLLKQI----EKSNSTQNIFISPWSISSTLAIVLLGAGGNTEQQMAKVLQFNEIGSYGIT 69
            |..|....|:|    .||::.||:.:||.||.:.|::|.:||.|:|.:::...|        |:.
  Fly    11 TSVACQTSKEIYQLLSKSHTNQNLVVSPVSIETILSMVFMGAEGSTAKELQSAL--------GLP 67

Mouse    70 TRNPENFSGCDFAQQIQKENYPSAILQAQAGDKIHSAFSSLSSTINTPQGDYLLESANKLFGEKS 134
            :.:.|                           .:.:.:.:|.:.:...:...:|:.||:::....
  Fly    68 SEDKE---------------------------AVAARYGALLNDLQGQEEGPILKLANRIYVNDQ 105

Mouse   135 ARFKEEYIQLSKKYYSTEPEAVDFLECAEEAREKINSWVKTQTKGEIPNLLPEGSVDEDTKMVLV 199
            ....:.|....::.:.:|.|::. |.....|.|:||.||..||.|:|..::..||:..|.|.:||
  Fly   106 YSLNQNYNLAVREPFKSEAESIS-LTNGPVAAERINQWVLDQTSGKIKGMIDPGSMTSDVKALLV 169

Mouse   200 NAVYFKGKWKTPFEKKLNGLYPFRVNSHESIPVQMMFLHAKLNIGYIKDLKTQILELPH-TGNIS 263
            ||:||||:|::.|:........|:|.:::|:|||||.........|.:||..|::|||: ..|:|
  Fly   170 NAIYFKGQWESKFDPAKTRASTFQVTANKSVPVQMMAQMGTFRANYFRDLDAQVIELPYLNSNLS 234

Mouse   264 MLLLLPDEIEDASTGLELLESEI-NFANFNKWISKDTLDEDDVVVYIPKFKLAQSYELKSILQSM 327
            |.:.||.|:|    ||..||.:| .||.        .|...:|.:.:||||:....|||..|:.:
  Fly   235 MTIFLPREVE----GLSALEEKIVGFAR--------PLVAKEVYLKLPKFKIEFRDELKETLEKL 287

Mouse   328 GMEDAFNKGKANFSGM-SERNDLFLSEVFHQASVDVTEEGTVAAGGTGAVMTGRTGHGGPQFVAD 391
            |:.:.|. .|::.||: ::::...:|:|.|:|.::|.|||..|||.|...:|.|.|. ....:||
  Fly   288 GIRELFT-DKSDLSGLFADKSGGKVSQVSHKAFLEVNEEGAEAAGATSVAVTNRAGF-STFLMAD 350

Mouse   392 HPFLFFIMDKITHTILFVGRFSSP 415
            |||.|.|.|  .:||.|.||..||
  Fly   351 HPFAFVIRD--ANTIYFQGRVVSP 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Serpinb2	NP_001167641.1	SERPIN	4..415	CDD:294093	125/412 (30%)
Spn42Dd	NP_001163067.1	SERPIN	16..369	CDD:238101	122/404 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	216	1.000	Domainoid score	I2692
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3582
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		otm44262
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.980