DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment chil-23 and Cht10

DIOPT Version :9

Sequence 1:	NP_001254212.1	Gene:	chil-23 / 187739	WormBaseID:	WBGene00011167	Length:	432	Species:	Caenorhabditis elegans
Sequence 2:	NP_001036422.1	Gene:	Cht10 / 3355116	FlyBaseID:	FBgn0250907	Length:	2286	Species:	Drosophila melanogaster

Alignment Length:	480	Identity:	109/480 - (22%)
Similarity:	195/480 - (40%)	Gaps:	117/480 - (24%)

- Green bases have known domain annotations that are detailed below.

Worm     1 MTNIKSEQKESEELVLPNDRPQYEQ-RVTKQPTSGKYIIITITLISIIIVGFGLGLCAQIYFQAE 64
            |...::|.:|.|.::.||...:.|. ..|:..|..|.|                  |   ||...
  Fly  1375 MQTCENEGEEHEGILDPNHVLEEENIEATEMATEFKII------------------C---YFTNW 1418

Worm    65 SDVLPICDKRIIGYYSGSGTSNITSTQLSNL-THTVFAFVYMTPDGTLLFNNQIE--------KN 120
            :            :|...|...:.....|:| ||.::.|..::.|     |..|:        .|
  Fly  1419 A------------WYRQGGGKFLPEDIDSDLCTHIIYGFAVLSRD-----NLTIQPHDSWADLDN 1466

Worm   121 RFLKLKEVVRNGNSKIKLMFSIGGKDNS---KYFSSVIPSEERIQTFIESILEFLEAYDLDGVDL 182
            :|.:.....|...:|:.:  :|||.::|   || |.::.:.|....||.::|:|:|.|:.||:||
  Fly  1467 KFYERIVAYRKKGAKVTV--AIGGWNDSAGDKY-SRLVRNPEARSRFIRNVLDFIEEYNFDGLDL 1528

Worm   183 FWKWP----------EEEYRDAYFAFINQLRKTFEAKKKYYILSIVIPPPTLDGWGKKRLNKIIE 237
            .|::|          ..|.:..:.|.:.:|...|:.:.  .|||..:.|      .||.::...|
  Fly  1529 DWEYPVCWQVDCKKGTAEEKIGFSALVRELFYAFQPRG--LILSAAVSP------NKKVIDAGYE 1585

Worm   238 SVD------FINAYSTDYYTPLADNLSDDIAGPSAPIYFGAQGKSERNVHHTARNYSCLTKQASK 296
            ..:      :|:..:.||:     ...|...|..||:|...:|.:..|.:.:...:..:.....|
  Fly  1586 VAELSHYFSWISVMAYDYH-----GQWDKKTGHVAPMYSHPEGTANFNANFSMNYWISMGADRRK 1645

Worm   297 FNIVIPFYATLWENVYETVLDSKRGVYRHV--APFY-GRTVGKTYLSR--LAVKQEGFQVESYSY 356
            ..:.||.|...: ::.||.        :|.  ||.| |...|:...:|  ||..:...::..:.:
  Fly  1646 LVMGIPLYGQSF-SLAETT--------KHQLNAPTYGGGEAGEATRARGFLAYYEICLKIRHHRW 1701

Worm   357 ----DPAPR-AAFSYNRTIGIYLTFETKESIRAKIDYVKDRILGGVWIFSVDMDD-------ETN 409
                |...| ..|:|:.  ..:::|:....||.|.:|:|...|||..|:::|:||       |:.
  Fly  1702 NVVRDTKGRIGPFAYHG--DQWVSFDDVPMIRHKSEYIKAMGLGGAMIWALDLDDFKNVCECESY 1764

Worm   410 SQLKAVS--FDGFCTIGNGSKYECV 432
            ..|||::  ..||    .|.:.:|:
  Fly  1765 PLLKAINRVLRGF----GGPQPKCL 1785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chil-23	NP_001254212.1	Glyco_18	74..405	CDD:214753	85/368 (23%)
Cht10	NP_001036422.1	Glyco_18	220..565	CDD:214753
		GH18_chitolectin_chitotriosidase	221..586	CDD:119351
		ChtBD2	697..737	CDD:214696
		CBM_14	801..848	CDD:279884
		CBM_14	875..918	CDD:279884
		Glyco_18	966..1310	CDD:214753
		GH18_chitolectin_chitotriosidase	967..1331	CDD:119351
		Glyco_18	1410..1753	CDD:214753	90/407 (22%)
		GH18_chitolectin_chitotriosidase	1411..1774	CDD:119351	95/427 (22%)
		ChtBD2	1834..1871	CDD:214696
		Glyco_18	1909..2253	CDD:214753
		GH18_chitolectin_chitotriosidase	1910..2274	CDD:119351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164218
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840