DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkp1 and p120ctn

DIOPT Version :9

Sequence 1:	NP_001300630.1	Gene:	Pkp1 / 18772	MGIID:	1328359	Length:	728	Species:	Mus musculus
Sequence 2:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster

Alignment Length:	721	Identity:	189/721 - (26%)
Similarity:	314/721 - (43%)	Gaps:	113/721 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse   108 TLKREPDNRRFSSYSQMENWSRHYPRGSCATP-------GAG-----SDICFMQKIKASRSE--- 157
            :|..||.|.: |.:...:|:.:....|..:||       |.|     :..|...||:.:.::
  Fly    25 SLTHEPANMQ-SQFGSFQNYDQFSAAGYSSTPLYITKPTGVGAITKVAPHCSQNKIETNSTDNSI 88

Mouse   158 PDLYCDPRGTLRKGTLGSKGHKTTQN-----RCSFYSTCSGQKAVKKCPVRPPSCTSKQDPV-YV 216
            ||:...|..|..:.....:...|::.     .|...|..:.:..|..|.....:.|..|:.. .:
  Fly    89 PDIENHPLATTVRYVQAGQYEDTSEYGVAGLTCGIDSEYTAEAVVPYCYTSDANYTGIQNTTSSI 153

Mouse   217 PPIS---CNKDLSFGHSRASSKIC-----------------------------------SEDIEC 243
            .|.|   .|.:::...:.|.|: |                                   ||:..|
  Fly   154 KPFSGRPFNDNINGAEAVADSQ-CRTFKSSAEFKLPQFAMSSINTVPQRLEEKDDYIEGSENDIC 217

Mouse   244 SGL-----TIPKAVQYLCSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQN 303
            |.:     .:.:.:.:|.:.....:|..|.|:||.|:.|:..||:...||||..||.||...:..
  Fly   218 STMRWRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPE 282

Mouse   304 VQQAAAGALRNLVF--RSTPNKLETRRQNGIREAVSLLRRSGSTEIQKQLTGLLWNLSSTDELKE 366
            :.:.|.||||||.:  ::..||...:...||...|.||.||..||:::.:||:|||:||.::||.
  Fly   283 IHKNACGALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLWNMSSCEDLKR 347

Mouse   367 ELVADALPVLTDRVIIPFSGW---CDGNSNMSREVVDPEVFFNATGCLRNLSSA-DAGRQTMRNY 427
            .::.:||..:...||.|.|||   |.|.:..|      .||.||:|.|||:||| :..|..:||.
  Fly   348 SIIDEALVAVVCSVIKPHSGWDAVCCGETCFS------TVFRNASGVLRNVSSAGEHARGCLRNC 406

Mouse   428 SGLIDSLMAYVQNCVAASRCDDKSVENCMCILHNLSYRLDAEVPTRYRQLEYNTRNAYTEKSS-- 490
            ..|::.|:..|:..:..:...:|:||||:|||.|||||........|.:..:.|.......||
  Fly   407 EHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQEVDDPNYDKHPFITPERVIPSSSKG 471

Mouse   491 --TGCFSNRGDKMMNNNYDCPLPEEETNP-------------KGSSWLYHSDAIRTYLNLMGKSK 540
              .|||.....|...||.|. |.|...:.             ||...|:..:.::.||:|:....
  Fly   472 ENLGCFGTNKKKKEANNSDA-LNEYNISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQSCS 535

Mouse   541 KDATLEACAGALQNLTASKGLMSNGMSQLIGIKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRH 605
            ...||||.|||:|||:|.....|..:...:. ||||||.:..||:.....||.:.|:.|.|::..
  Fly   536 NPETLEAAAGAIQNLSACYWQPSIDIRATVR-KEKGLPILVELLRMEVDRVVCAVATALRNLAID 599

Mouse   606 PVLHRVMGNQVFPEVTRLLTS----HTGNTSNSEDILSSACYTVRNLMTSQPQMAKQYFSNSMLN 666
            .....::|.....::.:.|.|    |..||  |:|.:::...|:..::...|:.::....:..::
  Fly   600 QRNKELIGKYAMRDLVQKLPSGNVQHDQNT--SDDTITAVLATINEVIKKNPEFSRSLLDSGGID 662

Mouse   667 NVFNLC-RNTASSPKAAEAARLLLSDMWASKELQSVLRQQGF-DRNMMGN--------IAGANNL 721
            .:.|:. |....:....:.|..:|..||...||:.|.::.|: :::.:..        .:..||:
  Fly   663 RLMNITKRKEKYTSCVLKFASQVLYTMWQHNELRDVYKKNGWKEQDFVSKHFTAHNTPPSSPNNV 727

Mouse   722 RNFTSR 727
            .|..:|
  Fly   728 NNTLNR 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkp1	NP_001300630.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..69
		armadillo repeat	240..273	CDD:293788	7/37 (19%)
		ARM 1	244..275		7/35 (20%)
		ARM 2	276..317		18/40 (45%)
		ARM	277..317	CDD:214547	18/39 (46%)
		armadillo repeat	281..317	CDD:293788	17/35 (49%)
		ARM 3	318..360		16/41 (39%)
		ARM	319..360	CDD:214547	16/40 (40%)
		armadillo repeat	323..358	CDD:293788	14/34 (41%)
		ARM 4	361..412		18/53 (34%)
		armadillo repeat	365..416	CDD:293788	20/53 (38%)
		ARM 5	413..443		10/30 (33%)
		ARM 6	505..536		9/43 (21%)
		ARM 7	537..583		18/45 (40%)
		armadillo repeat	569..604	CDD:293788	13/34 (38%)
		ARM 8	584..629		10/48 (21%)
		armadillo repeat	610..648	CDD:293788	9/41 (22%)
		ARM 9	630..694		11/64 (17%)
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	41/113 (36%)
		armadillo repeat	227..252	CDD:293788	5/24 (21%)
		armadillo repeat	260..296	CDD:293788	17/35 (49%)
		armadillo repeat	304..339	CDD:293788	14/34 (41%)
		ARM	307..442	CDD:237987	55/140 (39%)
		armadillo repeat	347..392	CDD:293788	18/50 (36%)
		armadillo repeat	515..556	CDD:293788	15/40 (38%)
		ARM	516..643	CDD:237987	38/129 (29%)
		armadillo repeat	562..596	CDD:293788	12/34 (35%)
		armadillo repeat	601..641	CDD:293788	8/41 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839541
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.800