DRSC/TRiP Functional Genomics Resources

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Protein Alignment E4F1 and CG14667

DIOPT Version :9

Sequence 1:XP_005255212.1 Gene:E4F1 / 1877 HGNCID:3121 Length:837 Species:Homo sapiens
Sequence 2:NP_001014607.1 Gene:CG14667 / 40643 FlyBaseID:FBgn0037317 Length:337 Species:Drosophila melanogaster


Alignment Length:256 Identity:70/256 - (27%)
Similarity:112/256 - (43%) Gaps:54/256 - (21%)


- Green bases have known domain annotations that are detailed below.


Human   388 VHVQMQELSLGMKALAPEPPVSQELPCSS-------------EGSRENLLHQAMQNSGIVLERAA 439
            |||:          |:.||...|.:....             :|::|.  ||.:           
  Fly    91 VHVE----------LSSEPLDEQLIDADQLETHYDDDQYVCYQGTKEE--HQDL----------- 132

Human   440 GEEGALEPAPAAG--SSPQPLAVAAPQLPVLEVQPLETQVASEASAVPRTH--PCPQCSETFPTA 500
             ||..|:..|:|.  ::.:..|.||.|      :.|:.| ..|.:|..|::  .|.:|...|..|
  Fly   133 -EEIELDDDPSAAVIAAAEAAAEAAQQ------EDLQEQ-EMERAAKRRSNFFICDECGTLFHDA 189

Human   501 ATLEAHKRGHTGPRP----FACAQCGKAFPKAYLLKKHQ-EVHVRERRFRCGDCGKLYKTIAHVR 560
            .....|..||...|.    |.|.:|.:.|.|..|||:|: :||:..|||:|..|.:.:.::....
  Fly   190 FLYTEHLNGHQNRRDMNQFFPCPECPQTFNKKALLKQHRTQVHLINRRFQCTICHEAFASLGAKL 254

Human   561 GHRRVHSDERPYPCPKCGKRYKTKNAQQVHFRTHLEE-KPHVCQFCSRGFREKGSLVRHVR 620
            .|.:.|.:||||||.:||..:.:.:..|.||.||.:: :...|:.|:..|..:..||.|.:
  Fly   255 RHDKAHKNERPYPCLECGMIFSSVSELQNHFSTHSKQIRKFRCEPCNMDFITRRGLVAHTK 315

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E4F1XP_005255212.1 COG5048 236..648 CDD:227381 70/256 (27%)
C2H2 Zn finger 247..267 CDD:275368
zf-C2H2 273..295 CDD:278523
C2H2 Zn finger 275..295 CDD:275368
zf-H2C2_2 287..310 CDD:290200
zf-C2H2 301..322 CDD:278523
C2H2 Zn finger 303..321 CDD:275368
C2H2 Zn finger 490..510 CDD:275368 5/19 (26%)
DUF45 <506..585 CDD:302795 30/83 (36%)
C2H2 Zn finger 518..538 CDD:275368 8/20 (40%)
C2H2 Zn finger 546..566 CDD:275368 3/19 (16%)
zf-H2C2_2 558..583 CDD:290200 10/24 (42%)
C2H2 Zn finger 574..594 CDD:275368 6/19 (32%)
zf-H2C2_2 588..609 CDD:290200 7/21 (33%)
C2H2 Zn finger 602..622 CDD:275368 6/19 (32%)
zf-H2C2_2 614..638 CDD:290200 3/7 (43%)
C2H2 Zn finger 630..649 CDD:275368
CG14667NP_001014607.1 zf-AD 6..80 CDD:214871
C2H2 Zn finger 179..199 CDD:275368 5/19 (26%)
C2H2 Zn finger 211..232 CDD:275368 8/20 (40%)
C2H2 Zn finger 240..260 CDD:275368 3/19 (16%)
zf-C2H2_8 243..313 CDD:292531 21/69 (30%)
C2H2 Zn finger 268..288 CDD:275368 6/19 (32%)
C2H2 Zn finger 297..316 CDD:275368 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S5423
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.950

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