DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E4F1 and Kr-h1

DIOPT Version :9

Sequence 1:	XP_005255212.1	Gene:	E4F1 / 1877	HGNCID:	3121	Length:	837	Species:	Homo sapiens
Sequence 2:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster

Alignment Length:	772	Identity:	169/772 - (21%)
Similarity:	259/772 - (33%)	Gaps:	269/772 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   117 QAEFTALEDFVQHKIQKACQRAPPEALPATPATTAL-LGQEVVPAAPGPEEPITVAHIVVEAASL 180
            ||:|              |.:.||   |.|..||:: ||   ||.:.|.:|
  Fly    72 QAQF--------------CLQVPP---PLTATTTSVGLG---VPPSGGQQE-------------- 102

Human   181 AADISHASDLVGGGHIKEVIVAAEAELGDGEMAEAPGSPRQQGLGLAGEGEQAQ-----VKLLVN 240
                          |.              |:.:.| ..||..|.|..:.:|.|     .:|.:.
  Fly   103 --------------HF--------------ELLQTP-QQRQMQLQLQDQHQQEQQQFVSYQLAIQ 138

Human   241 KDGRYVCALCHKTFKTGSILKAHMVTHSSRKDHECKLCGASFRTKGSLIRHHRRHTDERP-YKCS 304
            :..:......|:     ||..|......|.:..:.:..| .|....:::...|:.:..:| :||.
  Fly   139 QHQKQQQQQQHE-----SITNAAPTAAPSAQRIKTEPVG-GFPASAAVVSQVRKPSASKPQFKCD 197

Human   305 KCGKSFRESGALTRHLKSLTPCTEKIRFSVSKDVVVSKEDARAGSGAGAAGLGTATSSVTGEPIE 369
            :||.:|....|.|.|.||         .|.::|:.::          ||:|.|.|.      |:.
  Fly   198 QCGMTFGSKSAHTSHTKS---------HSKNQDLSLN----------GASGAGVAA------PVS 237

Human   370 TSPVIHLVTDAKGTVIHEVHVQMQELS-LGMKALAPEPPVSQELPCSSEGSRENLLHQAMQNSGI 433
            |:.:                    ||: .|:....|:.|..:.|        .|:
  Fly   238 TAAI--------------------ELNDAGLPVGIPKSPTIKPL--------ANV---------- 264

Human   434 VLERAAGEEGALEPAPAAGSSPQPLAVAAPQLPVLEVQPLETQVASEASAVPRTHPCPQCSETFP 498
                            |||:.|                                :.|..|.:||.
  Fly   265 ----------------AAGADP--------------------------------YQCNVCQKTFA 281

Human   499 TAATLEAHKRGHTGPRPFACAQCGKAFPKAYLLKKHQEVHVRERRFRCGDCGKLYKTIAHVRGHR 563
            ..|.|..|.|.|||.|||.|..|.|.|.....|:.|:.:|.:||.::|..||:.::....:..|.
  Fly   282 VPARLIRHYRTHTGERPFECEFCHKLFSVKENLQVHRRIHTKERPYKCDVCGRAFEHSGKLHRHM 346

Human   564 RVHSDERPYPCPKCGKRYKTKNAQQVHFRTHLEEKPHVC--QFCSRGFREKGSLVRHVRHHTGEK 626
            |:|:.|||:.|..|.|.:.......:|.|||..|||:.|  ..|.:||.....|..|.|.|||||
  Fly   347 RIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPGCGKGFTCSKQLKVHSRTHTGEK 411

Human   627 PFKCYKCGRGFAEHGTLNRHLRTKGGCLLEVEELLVSEDSPAAATTVLTEDPHTVLVEFSSVVAD 691
            |:.|..|.|.|..:..|..|.....|             |.....|:..|    .......:.|.
  Fly   412 PYHCDICFRDFGYNHVLKLHRVQHYG-------------SKCYKCTICDE----TFKNKKEMEAH 459

Human   692 TQEYIIEATADDAETSEATEIIEGTQTEVDSHIMKVVQQIVHQASAGHQIIVQNVTMDEETA--- 753
            .:.:..|...|:||.:.|:   ....|...|             |||...: |.|:.:.|::
  Fly   460 IKGHANEVPDDEAEAAAAS---AAASTSAGS-------------SAGSPSL-QGVSSNSESSNHS 507

Human   754 --LGPEA--------------AAADTITIAT-----PESLTEQVAMTLASAIS------------ 785
              ..|.|              ..|.|::|.|     |.||:...:.:.:|..|
  Fly   508 PPSSPPATKKPRQARQPRVSKTVAATLSIPTSSPLSPSSLSSTYSPSASSMASPPPTSAHYLPVQ 572

Human   786 -EGTVLAARAGTSGTEQATVTMVSSE--DIEILEHAGEL------VIASPEGQLEVQ 833
             |...|:..:|.|..:.|..|....|  |:.:.:..|:|      ...:|...||:|
  Fly   573 MEADALSRDSGVSSAQPAHSTYADEEPTDLSMQQVQGQLPESTVDYYQAPPSLLELQ 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E4F1	XP_005255212.1	COG5048	236..648	CDD:227381	101/415 (24%)
		C2H2 Zn finger	247..267	CDD:275368	4/19 (21%)
		zf-C2H2	273..295	CDD:278523	3/21 (14%)
		C2H2 Zn finger	275..295	CDD:275368	3/19 (16%)
		zf-H2C2_2	287..310	CDD:290200	6/23 (26%)
		zf-C2H2	301..322	CDD:278523	8/20 (40%)
		C2H2 Zn finger	303..321	CDD:275368	7/17 (41%)
		C2H2 Zn finger	490..510	CDD:275368	8/19 (42%)
		DUF45	<506..585	CDD:302795	29/78 (37%)
		C2H2 Zn finger	518..538	CDD:275368	6/19 (32%)
		C2H2 Zn finger	546..566	CDD:275368	5/19 (26%)
		zf-H2C2_2	558..583	CDD:290200	9/24 (38%)
		C2H2 Zn finger	574..594	CDD:275368	5/19 (26%)
		zf-H2C2_2	588..609	CDD:290200	9/22 (41%)
		C2H2 Zn finger	602..622	CDD:275368	7/21 (33%)
		zf-H2C2_2	614..638	CDD:290200	12/23 (52%)
		C2H2 Zn finger	630..649	CDD:275368	6/18 (33%)
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	9/28 (32%)
		COG5048	<270..420	CDD:227381	58/181 (32%)
		zf-C2H2	271..293	CDD:278523	8/21 (38%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	286..309	CDD:290200	12/22 (55%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		zf-H2C2_2	313..338	CDD:290200	8/24 (33%)
		C2H2 Zn finger	329..349	CDD:275368	5/19 (26%)
		zf-H2C2_2	344..366	CDD:290200	9/21 (43%)
		C2H2 Zn finger	357..377	CDD:275368	5/19 (26%)
		zf-H2C2_2	370..396	CDD:290200	11/25 (44%)
		C2H2 Zn finger	385..407	CDD:275368	7/21 (33%)
		zf-H2C2_2	400..424	CDD:290200	13/23 (57%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-C2H2	441..463	CDD:278523	3/25 (12%)
		C2H2 Zn finger	443..463	CDD:275368	3/23 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100