DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and Pkd2

DIOPT Version :9

Sequence 1:	NP_032887.3	Gene:	Pkd2 / 18764	MGIID:	1099818	Length:	966	Species:	Mus musculus
Sequence 2:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster

Alignment Length:	1023	Identity:	257/1023 - (25%)
Similarity:	411/1023 - (40%)	Gaps:	280/1023 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse    13 GDAGRSPA---------PRASGPGRLVAG-GAGLAVPGGLGEQRG---------LEIEMERIRQA 58
            |.:||||:         |..:.||....| ....:.||.:...||         :.|.:...|.|
  Fly     5 GQSGRSPSGPPGPPPPRPPKTPPGASPRGTPTADSTPGDVTPARGPPPPPATKRVSIGVGSTRSA 69

Mouse    59 --AARDP------------PAGASASPSPPLSSCSRQAWSRDNPGFEAEEDDDDDEVEGEEGGMV 109
              .|.||            ..|.|.||.|.|....:.  :.|.|. .:::....|:........|
  Fly    70 PPPATDPTGPPPTAGKPVRDTGPSTSPRPSLRDPGQS--TSDKPS-TSDKPSTSDKPSTSARTTV 131

Mouse   110 VEMDVEWRPGSRRSASSSAVSSVGARGRGLGSYRGAAHLSGR----------------------- 151
            .|      ||    .|||....|..|..|..:::.||..:..
  Fly   132 RE------PG----PSSSPSRPVSTRESGRITFQEAAPSTSAKVVKLAASEPRPAKPPEKEGFSL 186

Mouse   152 -RRRLEDQGAQC-PSPAGGGDPLHRHLPLEGQPPRVAWAERLVRGLRGLWGTRLMEESNANREKY 214
             :|:.:..|:.. |||:.|    ||      .|..:|             .:.|...:..||..|
  Fly   187 FKRKKKSVGSSTPPSPSRG----HR------APSIIA-------------ASALQNRAKTNRILY 228

Mouse   215 -----LKSVLRELVTYLFFLVVLCILTYGMMSSNVYYYTRTLSQLFI--DTPVSKTEKTNFKTLS 272
                 ::..|.|...::.||::..::...:..:.::|:..|:.:||.  :..|:.:....|:.|.
  Fly   229 TTDEEVREALVEFSVFIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREMVVAPSVTVGFEKLI 293

Mouse   273 SMEDFWKFTEGSFLDGLYWKAQTSNHTQAD----------------------------------- 302
            ::.|:|.:.:.:||..|:......:..||:
  Fly   294 TVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEAPEE 358

Mouse   303 ----------------------------------------------------------NRSF--- 306
                                                                      |.||
  Fly   359 APEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDDSDSIQANMSFHHL 423

Mouse   307 ----IFYENLLLGVPRLRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWMYT 367
                ..|||||||.|||||:|||..||.:..........||..||..:|||.|.  ..|:.  :.
  Fly   424 EGRVFLYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSGAEDRKPM--HKGSP--FR 484

Mouse   368 SEKELNGSSHWGIIASYSGAGYYLDLSRTREETAAQLAGLRRNFWLDRGTRAAFIDFSVYNANIN 432
            :..:|:.:..|.::|.|...||.::|...::.....:..|:...|||||:|...::|:::|.|.:
  Fly   485 TMHDLDSTPIWTVLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTD 549

Mouse   433 LFCVVRLLAEFPATGGVVPSWQFQPVKLIRYVTAFDFFLAACEIIFCFFIIYYVVEEILEIRIHR 497
            :|..::|:||.|.||||:|....|.||:..:.|.....:....|.:...:|||.:.||.|||...
  Fly   550 IFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSMLMTVIYIFWYIMVIYYTIYEITEIRKSG 614

Mouse   498 LS-YFRSFWNCLDVVIVVLSVVAMVINIYRMSNAEGLLQFLEDQNSFPNFEHVAYWQIQFNNISA 561
            :. ||.|..|.||..|::...:|:|.||:.......|........::.:.:.:.:|.|.:.::.|
  Fly   615 IKIYFCSMLNILDCAILLGCYLALVYNIWHSFKVMSLTARAHSDVTYQSLDVLCFWNIIYVDMMA 679

Mouse   562 VMVFLVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFTIMFSIIFLAYAQLAYLVFGTQVDDFST 626
            ::.||||||:||||:||:|:.|.:||:.||:|||.||::||.|:|||||||..|:|||:..||..
  Fly   680 ILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRN 744

Mouse   627 FQECIFTQFRIILGDINFAEIEEANRVLGPLYFTTFVFFMFFILLNMFLAIINDSYSEVKSDLAQ 691
            |...|.|..|:||||..:..||:|||||||:||.|::..:||||||||||||.::|:.||.::.|
  Fly   745 FITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNTVKGEITQ 809

Mouse   692 QKAEMELSDLIRKGCQKALVKLKLKRNTVDAISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAI 756
            .::.:                                   |...:.:|...|....|...:
  Fly   810 GRSHL-----------------------------------GSYIYRKLSGMLYWITHCGRK---- 835

Mouse   757 FTKYDQDGDQELTEREHQQMRDDLEKEREDLDLEHSSLPRPMSSRSFPRSLDDSEEEDDEDSGHS 821
                         .|.|.|     ..|.||.|.||........:....:::..:|::..:|
  Fly   836 -------------RRHHPQ-----ASETEDKDAEHDVGAAHDETHEIRKNMTPAEQQYFKD---- 878

Mouse   822 SRRRGSISSGVSYEEFQVLVR---RVDRMEHSIGSIVSKIDAVIVKLE 866
                  |..|    |.|.:||   ||..:|..:..:::.:|.::.::|
  Fly   879 ------IPQG----ENQDMVRLNNRVGLLEEILEKLINNMDDILKRVE 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_032887.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..106		28/125 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..179		8/56 (14%)
		PKD_channel	265..685	CDD:285288	165/520 (32%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:Q13563	639..641		1/1 (100%)
		EFh	730..776	CDD:298682	6/45 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..828		11/63 (17%)
		Linker. /evidence=ECO:0000250\|UniProtKB:Q13563	801..820		2/18 (11%)
		Important for interaction with PACS1 and PACS2. /evidence=ECO:0000250\|UniProtKB:Q13563	808..819		2/10 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	914..966
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	135/401 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841946
Domainoid	1	1.000	313	1.000	Domainoid score	I1300
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	356	1.000	Inparanoid score	I2221
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002518
OrthoInspector	1	1.000	-	-		otm42741
orthoMCL	1	0.900	-	-		OOG6_103020
Panther	1	1.100	-	-	O	PTHR10877
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2725
SonicParanoid	1	1.000	-	-		X1653
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780