DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd1 and brv2

DIOPT Version :9

Sequence 1:	XP_036016298.1	Gene:	Pkd1 / 18763	MGIID:	97603	Length:	4316	Species:	Mus musculus
Sequence 2:	NP_648970.2	Gene:	brv2 / 39932	FlyBaseID:	FBgn0036712	Length:	736	Species:	Drosophila melanogaster

Alignment Length:	790	Identity:	153/790 - (19%)
Similarity:	259/790 - (32%)	Gaps:	246/790 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse  3573 GLSLLLVAVA-VAVSGWIGASFPPSVSVMWLLSSSSSFLASFLGWEPLKVLLEALYFSLVAKRLH 3636
            |::..:|.|. |.||.:.|....|......|::....|...:|..||::..::::.::     ..
  Fly    15 GVTTCVVMVCFVLVSIFSGFMHEPQRFKTMLVTIVLVFFFQYLILEPIRFFIQSIDYA-----TW 74

Mouse  3637 PDEDDTL---VESPAVTPVSERVPRVRPPHGFALFLAKEEARKVKRLHDMLKR----LLVY---- 3690
            |.||...   ...|.:..:.....|:|......|.   .|....:.|:...|.    ||:|
  Fly    75 PQEDPPYRAEEGGPTMDHIGYLKIRLRSLRSELLI---SEGHTNEMLNQKYKHIAGDLLLYGSYF 136

Mouse  3691 -MLFLLVTLL---ANYGDAS------------CHG-----HAYRLQSAIKQELDSQAFLAITRSD 3734
             .|.|:|.|.   .||.:.:            ..|     ..|::.|.:|..|....:...|...
  Fly   137 IALMLMVVLQEDHTNYYNTNNMQRLFWDNTSVTFGLSQVYFIYQVHSYMKITLVEAFYAQKTNGY 201

Mouse  3735 EFWPWMSHVFLPYVHGNQSSPELGPPRLRQVRLQEAFCPDPSSSEHMCSAAGSLSTSDYGIGWQS 3799
            |.| |          ..:...::|..||||:|..:.         |:...........|...|:.
  Fly   202 EGW-W----------AMEQWQKIGVVRLRQMRPVDC---------HIGLGKPEWDKKTYAPEWRL 246

Mouse  3800 VVQNGSET---WAYSAPD-------------LLGAWYWGYCAVY-DSGGYIQELGLSLEESRARL 3847
            .......|   |....|.             ||...::||...| :..||:..:..:......::
  Fly   247 PYHRMHYTEKFWRIYDPFVPAEFEPSFLNGLLLNYDHYGYLLNYPEVAGYVVLMMSTKINCLKQI 311

Mouse  3848 GFLQLHNWLDSRSRAVFVELTRYSPAVGLHAAVTLRLEFPVAGHALAAFSVRPFALRRLSTGLSL 3912
            .:|:.::|||..:.|:|::||.|:....|...:|||:|            ..||       |:.|
  Fly   312 EYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVE------------NSPF-------GIQL 357

Mouse  3913 PLLTSVCLLLFALYFSMAEVQTWRKDGCACTARPDTWARCLLVILTAATGLVRLAQLGIADRQWT 3977
            |.:                    ..|..:.....:|.:...|:||...|.||.|...|:..:.|.
  Fly   358 PRV--------------------HVDSVSMLGNVETRSNSELLILFVYTVLVILFARGVFTKIWH 402

Mouse  3978 HFVQDHPRHFTSFDQVAQLGSV-------ARGLAASLLFLLLVKAAQ-------------QLRFV 4022
            |....| ..:|..|....:.:|       .|.:....|..::..|.:             |:.|:
  Fly   403 HPAAAH-EAWTMVDLAIYILNVFLTVLAIMRDIETDALLQIIETATKGQYLDFQRPLRLHQMLFI 466

Mouse  4023 -----------RQWSV---------FGKTLCRALPELMGATLGLVLLGVAYAQMAILLISSGADT 4067
                       |.|.|         |.:||..|...:  |:||:::|.|..|....|.:.:|
  Fly   467 VKGFLVCITTLRLWKVLQFASVFQHFTQTLFSAWRAV--ASLGVIILVVLMAIGITLAVPNG--- 526

Mouse  4068 LYNMARAF------LVLC-----------------PGARVPTLCPSESWYLSPLLCVGLWALRVW 4109
              |.|..|      :|.|                 .|.|:..:.    .||:.:..:.:..:.|:
  Fly   527 --NNAVVFSHMVQSVVTCMWYSMGFNGDIHPADFFHGGRILGIL----LYLALVFLLAIILMNVF 585

Mouse  4110 GAL------RLGAIL--------------LRWRYHALRGELY---RPAWEPQDY---EMVELFLR 4148
            .::      ....||              |...|..|.|:.:   |..:|.:.:   |.|||.|.
  Fly   586 ASVIYDYFNETSRILKEHSNRSSITFLEFLHVEYADLFGDAFRCLRKTYESRGHTVAENVELELN 650

Mouse  4149 RLRLWMGFSK--------------VKEFR---HKVRFEGMDPLPS----------RSSRGSKSSP 4186
            |..| :.|.:              .:|.|   :::|.|.:..|.:          |...|.|...
  Fly   651 RREL-IKFKRDLIKSPQELKRALLTEEQRSADYRLRGEKLFKLMAILNLQVEILERMVLGDKDGK 714

Mouse  4187 VVLPPSSGSE 4196
            :..||:|.|:
  Fly   715 LPTPPASDSD 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd1	XP_036016298.1	LRRNT	32..71	CDD:214470
		LRR_8	61..127	CDD:404697
		leucine-rich repeat	70..92	CDD:275378
		leucine-rich repeat	93..116	CDD:275378
		PCC	97..2731	CDD:188093
		leucine-rich repeat	117..129	CDD:275378
		GPS	3011..3060	CDD:413374
		PLAT_polycystin	3118..3237	CDD:238850
		PKD_channel	3726..4126	CDD:400395	92/499 (18%)
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	93/497 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820