DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pkd1 and Pkd2

DIOPT Version :9

Sequence 1:XP_036016298.1 Gene:Pkd1 / 18763 MGIID:97603 Length:4316 Species:Mus musculus
Sequence 2:NP_609561.2 Gene:Pkd2 / 34651 FlyBaseID:FBgn0041195 Length:924 Species:Drosophila melanogaster


Alignment Length:1077 Identity:211/1077 - (19%)
Similarity:335/1077 - (31%) Gaps:330/1077 - (30%)


- Green bases have known domain annotations that are detailed below.


Mouse  3304 DTTYSMGPVSSLISPGVDTVAIGLVSSVVVYPVYLAVLFLFRMSRSKVSGDQNPTPT-GQQALDV 3367
            |.|.:.||..   .|....|:||:.|:              |.:....:....|.|| |:...|.
  Fly    43 DVTPARGPPP---PPATKRVSIGVGST--------------RSAPPPATDPTGPPPTAGKPVRDT 90

Mouse  3368 DSYLD--PSVLDSSLLTLSGLTEQAFAGQVKNDLFLEDAKRLRPGTGNNVYVAYSLVCWPSSEGT 3430
            .....  ||:.|              .||..:|         :|.|.:.                
  Fly    91 GPSTSPRPSLRD--------------PGQSTSD---------KPSTSDK---------------- 116

Mouse  3431 LSWPDLLSDPSVVSSTLQRLTQGRPGCMLGSEEDGASLVSPSLPAKYLSASDEDLIHQVLADGAN 3495
               |.....||..:.|..|             |.|.| .|||.|                     
  Fly   117 ---PSTSDKPSTSARTTVR-------------EPGPS-SSPSRP--------------------- 143

Mouse  3496 NLVPTQDTLLETDLLTSLSSVPGEKTETLILQTVGEERPASMGLSWEQSPVTRLSRTGLVEGFQ- 3559
              |.|:    |:..:|...:.|....:.:.| ...|.|||        .|..:       |||. 
  Fly   144 --VSTR----ESGRITFQEAAPSTSAKVVKL-AASEPRPA--------KPPEK-------EGFSL 186

Mouse  3560 -KRLLPAWCAPLAHGLSLLLVAVAVAVSGWIGASFPPSVS------------------------- 3598
             ||...:                       :|:|.|||.|                         
  Fly   187 FKRKKKS-----------------------VGSSTPPSPSRGHRAPSIIAASALQNRAKTNRILY 228

Mouse  3599 -----VMWLLSSSSSFLASFLGWEPLKVL----LEALYFSLVAKRLHPDEDDTLVESPAVTPVSE 3654
                 |...|...|.|:. ||....|.||    ....||:...|:|..:.:  :|.:|:||...|
  Fly   229 TTDEEVREALVEFSVFII-FLILTSLVVLSVRHTYMFYFNDTMKKLFTNRE--MVVAPSVTVGFE 290

Mouse  3655 RVPRVRPP-------------HGFALFL------------------------------------- 3669
            ::..| |.             ||...|:                                     
  Fly   291 KLITV-PDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGE 354

Mouse  3670 AKEEARKVKRLHDMLKRLLVYMLFLLVTLLAN-YGDASCHGHAYRLQSAI--------------- 3718
            |.|||.::.||.:..|            ...| |.|...|..|.| ||.:               
  Fly   355 APEEAPEMDRLQEDFK------------YNGNPYIDLRGHRRAKR-QSGVDGNSEDGSEDVSGNY 406

Mouse  3719 -KQELDSQAFLAITRSDEFWPWMSHVFLPYVHGNQSSPELGPPRLRQVRLQEAFCPDPSS---SE 3779
             |.:.||     |..:..|......|||      ..:..||||||||:|:::..|....:   ..
  Fly   407 LKDDSDS-----IQANMSFHHLEGRVFL------YENLLLGPPRLRQIRVRKESCYVNDAFIRYF 460

Mouse  3780 HMCSAAGSLSTSDYGIGWQSVVQNGSETWAYSAPDLLGAWYWGYCAVYDSGGYIQELGLSLEESR 3844
            :.|.||.|....|     :..:..||.  ..:..||.....|...|.|.:|||...|....:.:.
  Fly   461 NTCYAAYSSGAED-----RKPMHKGSP--FRTMHDLDSTPIWTVLAFYRTGGYTVNLDYDKDRNV 518

Mouse  3845 ARLGFLQLHNWLDSRSRAVFVELTRYSPAVGLHAAVTLRLEFPVAGHALAAFSVRPFALRRLSTG 3909
            ..:..|:..:|||..||...||...::....:..::.|..|.|..|..:....::...:....|.
  Fly   519 KIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFTD 583

Mouse  3910 LSLPLLTSVCLL--LFALYFSMAEVQTWRKDGCA---CTARPDTWARCLLVILTAATGLVRLAQL 3969
            .|: |:|.:.:.  :..:|:::.|:...||.|..   |:         :|.||..|  ::....|
  Fly   584 RSM-LMTVIYIFWYIMVIYYTIYEITEIRKSGIKIYFCS---------MLNILDCA--ILLGCYL 636

Mouse  3970 GIADRQWTHF------VQDHPR-HFTSFDQVAQLGSVARGLAASLLFLLLVKAAQQLRFVRQWSV 4027
            .:....|..|      .:.|.. .:.|.|.:.....:...:.|.|.||:.:|..:.:.|.:....
  Fly   637 ALVYNIWHSFKVMSLTARAHSDVTYQSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLVQ 701

Mouse  4028 FGKTLCRALPELMGATLGLVLLGVAYAQMAILLISSGADTLYNMARAFLVLCP---GARVPTLCP 4089
            |..||.|...:|.|.:|...::.:||||:.:||..:......|...:.|.:..   |.....|..
  Fly   702 FTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSILTMIRMILGDFQYNLIE 766

Mouse  4090 SESWYLSPLLCVGLWALRVWGALRLGAILLRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWM 4154
            ..:..|.|:..:....|..:..|.:...::...|:.::||:.:.......|  :...|..:..|:
  Fly   767 QANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNTVKGEITQGRSHLGSY--IYRKLSGMLYWI 829

Mouse  4155 GFSKVKEFRHKVRFEGMDPLPSRSSRGSKSSPVVLPPSSGSEASHPSTSSSQ------PDGPSAS 4213
            .....|...|        |..|.:........|........|.....|.:.|      |.|.:..
  Fly   830 THCGRKRRHH--------PQASETEDKDAEHDVGAAHDETHEIRKNMTPAEQQYFKDIPQGENQD 886

Mouse  4214 LSRSTLKLEPEPSRLHAVFESLLVQFDRLNQATEDVY 4250
            :    ::|......|..:.|.|:...|.:.:..|..|
  Fly   887 M----VRLNNRVGLLEEILEKLINNMDDILKRVEKDY 919

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pkd1XP_036016298.1 LRRNT 32..71 CDD:214470
LRR_8 61..127 CDD:404697
leucine-rich repeat 70..92 CDD:275378
leucine-rich repeat 93..116 CDD:275378
PCC 97..2731 CDD:188093
leucine-rich repeat 117..129 CDD:275378
GPS 3011..3060 CDD:413374
PLAT_polycystin 3118..3237 CDD:238850
PKD_channel 3726..4126 CDD:400395 91/417 (22%)
Pkd2NP_609561.2 PKD_channel 402..803 CDD:285288 94/430 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841944
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3599
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

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