Protein Alignment Prkcz and aPKC

DIOPT Version :10

• Sequence 1: NP_032886.2
• Gene: Prkcz / 18762
• MGIID: 97602
• Length: 592
• Species: Mus musculus
• Sequence 2: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Alignment Length: 530
• Identity: 339/530 - (63%)
• Similarity: 404/530 - (76%)
• Gaps: 27/530 - (5%)

Mouse    70 VSSQMELEEAFRLVCQGRDEVLIIHVFPSIPEQPGMPCPGEDKSIYRRGARRWRKLYRANGHLFQ 134
            :.|:.|:|.|:..            |||::|:.||:.|.|||:|||||||||||||||.|||:||
  Fly   449 LQSEEEIEPAYAT------------VFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQ 501

Mouse   135 AKRFNRGAYCGQCSERIWGLSRQGYRCINCKLLVHKRCHVLVPLTCRRHMDSVMPSQEPPVDDKN 199
            ||||||.|:|..|.:|||||.|||::||.|||||||:||.||...|   .|...|..:...::.:
  Fly   502 AKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHC---TDQPEPLVKERAEESS 563

Mouse   200 DGV-----DLPSEETDGIAYISSSRKHDNIKDDSEDLKPVIDGVDGIKISQGLGLQDFDLIRVIG 259
            |.:     .||.|...|.|....:..|.:|........|:..|.     .:...|.||:||||||
  Fly   564 DPIPVPLPPLPYEAMSGGAEACETHDHAHIVAPPPPEDPLEPGT-----QRQYSLNDFELIRVIG 623

Mouse   260 RGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTS 324
            ||||||||:|.|::..:||||||:||.||.||||||||||||||||.||::||||||||||||.|
  Fly   624 RGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPS 688

Mouse   325 RLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGH 389
            |||.|||:|.|||||:||||||:|||||||||||||.:|||||||:|||||||||||||||.:||
  Fly   689 RLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGH 753

Mouse   390 IKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDI- 453
            ||||||||||||:.|||||||||||||||||||||||:|||||||||||||::||:|||||||:
  Fly   754 IKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLA 818

Mouse   454 -ITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAF 517
             .::|||.|||||||||||||.|||||.|||:|:.||||||||:|.:||||..::.|.||.||.|
  Fly   819 GASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPF 883

Mouse   518 FRSIDWDLLEKKQTLPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDVIKRIDQSEFEGFEYIN 582
            |:::||:|||:||..|||:|::..|..|.||..:||.|.|||||||:.||..|||||||||||:|
  Fly   884 FKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVN 948

Mouse   583 PLLLSAEESV 592
            |||:|.|:.|
  Fly   949 PLLMSLEDCV 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prkcz	NP_032886.2	PB1_aPKC	16..98	CDD:99725	6/27 (22%)
		Interaction with SQSTM1. /evidence=ECO:0000250	79..145		38/65 (58%)
		C1	129..183	CDD:412127	36/53 (68%)
		Protein Kinases, catalytic domain	236..592	CDD:473864	262/357 (73%)
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	36/56 (64%)
		STKc_aPKC	620..947	CDD:270740	249/326 (76%)