Protein Alignment Prkcz and Pkc98E

DIOPT Version :10

• Sequence 1: NP_032886.2
• Gene: Prkcz / 18762
• MGIID: 97602
• Length: 592
• Species: Mus musculus
• Sequence 2: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Alignment Length: 580
• Identity: 231/580 - (39%)
• Similarity: 310/580 - (53%)
• Gaps: 124/580 - (21%)

Mouse   116 RRGARRWRKLYRANGHLFQAKRFNRGAYCGQCSERIWGLSRQGYRCINCKLLVHKRCHVLVPLTC 180
            ||||.| |::::.|||.|.|....:..:|..|.|.|||:.:|||:|..|.|:|||:||:.|...|
  Fly   163 RRGAMR-RRVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKC 226

Mouse   181 RRHMDSVMPSQEPPVDDKNDGVDLPSE-----------------------------ETDG----- 211
            ....|......|.....:...|:||..                             ||.|
  Fly   227 PGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHK 291

Mouse   212 ----------------IAYISSS------------RKHDNIKDDSEDLKPVIDGVDG-------- 240
                            :|.|.||            .|:.| :...||......|.||
  Fly   292 RCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLN-QQGGEDNYGASLGADGDGAPGQSF 355

Mouse   241 ------------------------------IKISQGLG-----------LQDFDLIRVIGRGSYA 264
                                          :..|.|:|           |.||:.|:|:|:||:.
  Fly   356 RSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFG 420

Mouse   265 KVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLV 329
            ||:|...|..|:|||:||:||:.:..|:|:|...|||.:...|:::|||..|||||||..|||.|
  Fly   421 KVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFV 485

Mouse   330 IEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTD 394
            :||||||||||.:|:.|:.....|.|||||:.:||.|||..|:|||||||||:|||.:||.||.|
  Fly   486 MEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLAD 550

Mouse   395 YGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPD 459
            :||||||:..|..|:||||||:|||||||:.:|||.|||||||||||:|||||:.||:  .||
  Fly   551 FGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFE--ADN-- 611

Mouse   460 MNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTG-FSDIKSHAFFRSIDW 523
               ||.||..|:...:..|.:||.:|..:|||||.|:|::||||   || .::|:.|.||..:||
  Fly   612 ---EDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGC---TGDENEIRKHPFFAKLDW 670

Mouse   524 DLLEKKQTLPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDVIKRIDQSEFEGFEYINP 583
            ..|||:...|||:|::.:....:|||.:||.|...|||...:|::.|:|.||.||.::||
  Fly   671 KELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNP 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prkcz	NP_032886.2	PB1_aPKC	16..98	CDD:99725
		Interaction with SQSTM1. /evidence=ECO:0000250	79..145		11/28 (39%)
		C1	129..183	CDD:412127	24/53 (45%)
		Protein Kinases, catalytic domain	236..592	CDD:473864	185/398 (46%)
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	24/58 (41%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	5/53 (9%)
		STKc_nPKC_epsilon	412..729	CDD:270743	173/326 (53%)