Protein Alignment Prkci and aPKC

DIOPT Version :10

• Sequence 1: NP_032883.2
• Gene: Prkci / 18759
• MGIID: 99260
• Length: 595
• Species: Mus musculus
• Sequence 2: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Alignment Length: 633
• Identity: 373/633 - (58%)
• Similarity: 435/633 - (68%)
• Gaps: 110/633 - (17%)

Mouse    16 CGGGG--------------------DHSHQVRVKAYYRGDIMITHFE--------PSISFEGLCS 52
            ||||.                    .|.||    .|:...|   |:|        |::.. |:..
  Fly   383 CGGGSIAGGSIGGRSSVLGTIHNGHGHHHQ----QYHHECI---HYERLPIPVPIPTVPM-GVAP 439

Mouse    53 EVRDMCSFDNEQPFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPC 117
            ..:.|....                  :.|:.|:|.|:..            |||.||:.||:.|
  Fly   440 SSQQMSQHQ------------------LQSEEEIEPAYAT------------VFPNVPQAPGLSC 474

Mouse   118 PGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKC 182
            .|||:||||||||||||||..|||.||||||||||.||.|.||||||||||:|||.|||||||||
  Fly   475 DGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKC 539

Mouse   183 HKLVTIECGRHSLPPEPMM---------PMDQTMHP----------------DHTQTVIPYNPSS 222
            ||||...|   :..|||::         |:...:.|                ||...|.|  |..
  Fly   540 HKLVQKHC---TDQPEPLVKERAEESSDPIPVPLPPLPYEAMSGGAEACETHDHAHIVAP--PPP 599

Mouse   223 HESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKE 287
            .:.|:...:.:.::|              ||:|:||||||||||||:|.|::|.|||||||:||.
  Fly   600 EDPLEPGTQRQYSLN--------------DFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKA 650

Mouse   288 LVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEE 352
            ||.||||||||||||||||.||||||||||||||||.||||||||:|.|||||:||||||:||||
  Fly   651 LVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEE 715

Mouse   353 HARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPN 417
            |||||:||||||||:|||:|||||||||||||||.|||||||||||||||:||||||||||||||
  Fly   716 HARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPN 780

Mouse   418 YIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPR 482
            ||||||||||||||||||||||||::||:|||||||:.|:|:|||||||||||||||||.|||||
  Fly   781 YIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPR 845

Mouse   483 SLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFG 547
            ||||:||||||.||||:|.:|||||.::.|.||..||||:|:||:::|:|||.|||||.:..:..
  Fly   846 SLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRD 910

Mouse   548 LDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 595
            |.||..:||.|.||||||||.::..|||||||||||:||||||.|:||
  Fly   911 LANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSLEDCV 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prkci	NP_032883.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		4/24 (17%)
		Regulatory domain. /evidence=ECO:0000250	2..252		98/288 (34%)
		Required for interaction with RAB2. /evidence=ECO:0000250	2..28		7/31 (23%)
		PB1_aPKC	26..108	CDD:99725	13/89 (15%)
		Interaction with PARD6A. /evidence=ECO:0000250	72..91		4/18 (22%)
		Pseudosubstrate	125..134		8/8 (100%)
		C1_aPKC	139..193	CDD:410344	43/53 (81%)
		STKc_aPKC_iota	232..595	CDD:270769	274/362 (76%)
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	43/56 (77%)
		STKc_aPKC	620..947	CDD:270740	262/326 (80%)