DRSC/TRiP Functional Genomics Resources

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Protein Alignment Prkci and aPKC

DIOPT Version :9

Sequence 1:NP_032883.2 Gene:Prkci / 18759 MGIID:99260 Length:595 Species:Mus musculus
Sequence 2:NP_001260984.1 Gene:aPKC / 47594 FlyBaseID:FBgn0261854 Length:958 Species:Drosophila melanogaster


Alignment Length:633 Identity:373/633 - (58%)
Similarity:435/633 - (68%) Gaps:110/633 - (17%)


- Green bases have known domain annotations that are detailed below.


Mouse    16 CGGGG--------------------DHSHQVRVKAYYRGDIMITHFE--------PSISFEGLCS 52
            ||||.                    .|.||    .|:...|   |:|        |::.. |:..
  Fly   383 CGGGSIAGGSIGGRSSVLGTIHNGHGHHHQ----QYHHECI---HYERLPIPVPIPTVPM-GVAP 439

Mouse    53 EVRDMCSFDNEQPFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPC 117
            ..:.|....                  :.|:.|:|.|:..            |||.||:.||:.|
  Fly   440 SSQQMSQHQ------------------LQSEEEIEPAYAT------------VFPNVPQAPGLSC 474

Mouse   118 PGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKC 182
            .|||:||||||||||||||..|||.||||||||||.||.|.||||||||||:|||.|||||||||
  Fly   475 DGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKC 539

Mouse   183 HKLVTIECGRHSLPPEPMM---------PMDQTMHP----------------DHTQTVIPYNPSS 222
            ||||...|   :..|||::         |:...:.|                ||...|.|  |..
  Fly   540 HKLVQKHC---TDQPEPLVKERAEESSDPIPVPLPPLPYEAMSGGAEACETHDHAHIVAP--PPP 599

Mouse   223 HESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKE 287
            .:.|:...:.:.::|              ||:|:||||||||||||:|.|::|.|||||||:||.
  Fly   600 EDPLEPGTQRQYSLN--------------DFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKA 650

Mouse   288 LVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEE 352
            ||.||||||||||||||||.||||||||||||||||.||||||||:|.|||||:||||||:||||
  Fly   651 LVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEE 715

Mouse   353 HARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPN 417
            |||||:||||||||:|||:|||||||||||||||.|||||||||||||||:||||||||||||||
  Fly   716 HARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPN 780

Mouse   418 YIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPR 482
            ||||||||||||||||||||||||::||:|||||||:.|:|:|||||||||||||||||.|||||
  Fly   781 YIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPR 845

Mouse   483 SLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFG 547
            ||||:||||||.||||:|.:|||||.::.|.||..||||:|:||:::|:|||.|||||.:..:..
  Fly   846 SLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRD 910

Mouse   548 LDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 595
            |.||..:||.|.||||||||.::..|||||||||||:||||||.|:||
  Fly   911 LANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSLEDCV 958

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PrkciNP_032883.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 4/24 (17%)
Regulatory domain. /evidence=ECO:0000250 2..252 98/288 (34%)
Required for interaction with RAB2. /evidence=ECO:0000250 2..28 7/31 (23%)
PB1_aPKC 26..108 CDD:99725 13/89 (15%)
Interaction with PARD6A. /evidence=ECO:0000250 72..91 4/18 (22%)
Pseudosubstrate 125..134 8/8 (100%)
C1_1 141..193 CDD:278556 41/51 (80%)
STKc_aPKC_iota 232..595 CDD:270769 274/362 (76%)
aPKCNP_001260984.1 C1_1 498..550 CDD:278556 41/54 (76%)
S_TKc 616..884 CDD:214567 226/267 (85%)
STKc_aPKC 620..947 CDD:270740 262/326 (80%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 483 1.000 Domainoid score I403
eggNOG 1 0.900 - - E2759_KOG0695
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H37667
Inparanoid 1 1.050 837 1.000 Inparanoid score I449
Isobase 1 0.950 - 0 Normalized mean entropy S926
OMA 1 1.010 - - QHG45540
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003559
OrthoInspector 1 1.000 - - otm42329
orthoMCL 1 0.900 - - OOG6_104397
Panther 1 1.100 - - LDO PTHR24356
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2434
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1312.820

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