DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pitx2 and Ptx1

DIOPT Version :9

Sequence 1:	NP_001035967.1	Gene:	Pitx2 / 18741	MGIID:	109340	Length:	324	Species:	Mus musculus
Sequence 2:	NP_001138130.2	Gene:	Ptx1 / 43664	FlyBaseID:	FBgn0020912	Length:	610	Species:	Drosophila melanogaster

Alignment Length:	384	Identity:	159/384 - (41%)
Similarity:	195/384 - (50%)	Gaps:	103/384 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 HRAAGTKLSAASSPFCHHPQALAMASVLAPGQPR----------------------------SLD 48
            |.:||..|....|...||       :|:.|..|:                            |||
  Fly   143 HHSAGQDLVGGYSQHPHH-------TVVPPHTPKHEPLEKLRIWAETGDFRDSHSSMTAVANSLD 200

Mouse    49 SSKHRLEVHTISDTSSPEVAEKDK--GQQGKNEDV---------GAEDP-----------SKKKR 91
            |:  .|.....|.|||.....:|:  |.:..||..         |.::|           .|.||
  Fly   201 ST--HLNNFQTSSTSSISNRSRDRKDGNRSVNETTIKTENISSSGHDEPMTTSGEEPKNDKKNKR 263

Mouse    92 QRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQ- 155
            |||||||||||||||||.||.||||||||||||||:||||||||||||||||||||||||||..
  Fly   264 QRRQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWRKRERNAMN 328

Mouse   156 ----AELCKNGFGPQFNGLMQPY--DDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSS 214
                |...|:|||.||   |||:  |.:|..|.||||..   ..:.|.||.||:    .||||.|
  Fly   329 AAVAAADFKSGFGTQF---MQPFADDSLYSSYPYNNWTK---VPSPLGTKPFPW----PVNPLGS 383

Mouse   215 QSMFS-PPNSISSMSMSSSMVPSAVTG---VPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPT 275
            ....: ..||::..:..:|.|..::..   :|||..:||:|.:|:      .||..| |||..|.
  Fly   384 MVAGNHHQNSVNCFNTGASGVAVSMNNASMLPGSMGSSLSNTSNV------GAVGAP-CPYTTPA 441

Mouse   276 PPYVYR---DTC-----NSSLASLRLKAKQHSSFGYA---SVQNPAS-----NLSACQY 318
            .||:||   :.|     :||:|:||||||||:|.|:.   |..:|.|     .||||||
  Fly   442 NPYMYRSAAEPCMSSSMSSSIATLRLKAKQHASAGFGSPYSAPSPVSRSNSAGLSACQY 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pitx2	NP_001035967.1	COG5576	40..>149	CDD:227863	73/158 (46%)
		Homeobox	96..149	CDD:365835	49/52 (94%)
		OAR	282..299	CDD:367680	11/21 (52%)
Ptx1	NP_001138130.2	Homeobox	268..320	CDD:278475	48/51 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5928
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55454
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001767
OrthoInspector	1	1.000	-	-		otm42671
orthoMCL	1	0.900	-	-		OOG6_107540
Panther	1	1.100	-	-	O	PTHR45882
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3409
SonicParanoid	1	1.000	-	-		X469
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.940