DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pitx1 and Ptx1

DIOPT Version :9

Sequence 1:	NP_035227.1	Gene:	Pitx1 / 18740	MGIID:	107374	Length:	315	Species:	Mus musculus
Sequence 2:	NP_001138130.2	Gene:	Ptx1 / 43664	FlyBaseID:	FBgn0020912	Length:	610	Species:	Drosophila melanogaster

Alignment Length:	363	Identity:	143/363 - (39%)
Similarity:	188/363 - (51%)	Gaps:	94/363 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse    19 PPPPPPHDMGPSFHL-ARAADPREP---------------LENSASESSDA------DLPDKERG 61
            ||..|.|:......: |...|.|:.               |.|..:.|:.:      |..|..|.
  Fly   164 PPHTPKHEPLEKLRIWAETGDFRDSHSSMTAVANSLDSTHLNNFQTSSTSSISNRSRDRKDGNRS 228

Mouse    62 GEAKGPEDGGAGSAG-------CGGGAEDPAKKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSM 119
            ......:.....|:|       .|...::..|.|:|||||||||||||||||.||.||||||||.
  Fly   229 VNETTIKTENISSSGHDEPMTTSGEEPKNDKKNKRQRRQRTHFTSQQLQELEHTFSRNRYPDMST 293

Mouse   120 REEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQ------LDLCKGGYVPQFSGLVQPYED--VY 176
            |||||:||||||.|||||||||||||||||||..      .|. |.|:..||   :||:.|  :|
  Fly   294 REEIAMWTNLTEARVRVWFKNRRAKWRKRERNAMNAAVAAADF-KSGFGTQF---MQPFADDSLY 354

Mouse   177 AAGYSYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQ----------SMFSAPSSISSMTM-PSSM 230
            :: |.||||   :..|:||.||.|.:  .::||.|.          :.|:..:|..:::| .:||
  Fly   355 SS-YPYNNW---TKVPSPLGTKPFPW--PVNPLGSMVAGNHHQNSVNCFNTGASGVAVSMNNASM 413

Mouse   231 GPGAVPGMPNSGLNNINNLTGSSLNSAMSPGA----CPYGTPASPYSVYR---DTC-----NSSL 283
            .||::               ||||::..:.||    |||.|||:|| :||   :.|     :||:
  Fly   414 LPGSM---------------GSSLSNTSNVGAVGAPCPYTTPANPY-MYRSAAEPCMSSSMSSSI 462

Mouse   284 ASLRLKSKQHSSFGYG---GLQGPAS-----GLNACQY 313
            |:||||:|||:|.|:|   ....|.|     ||:||||
  Fly   463 ATLRLKAKQHASAGFGSPYSAPSPVSRSNSAGLSACQY 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pitx1	NP_035227.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..104		31/113 (27%)
		Homeobox	94..147	CDD:365835	47/52 (90%)
		Interaction with PIT-1	151..280		48/159 (30%)
		Forkhead_N	196..>275	CDD:369872	27/93 (29%)
		OAR	277..294	CDD:367680	10/21 (48%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	281..294		9/12 (75%)
		Nuclear localization signal. /evidence=ECO:0000255	287..291		3/3 (100%)
Ptx1	NP_001138130.2	Homeobox	268..320	CDD:278475	46/51 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5928
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1432356at2759
OrthoFinder	1	1.000	-	-		FOG0001767
OrthoInspector	1	1.000	-	-		otm42671
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45882
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X469
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.020