DRSC/TRiP Functional Genomics Resources

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Protein Alignment E2F4 and E2f1

DIOPT Version :10

Sequence 1:NP_001941.2 Gene:E2F4 / 1874 HGNCID:3118 Length:413 Species:Homo sapiens
Sequence 2:NP_001262809.1 Gene:E2f1 / 42550 FlyBaseID:FBgn0011766 Length:821 Species:Drosophila melanogaster


Alignment Length:10 Identity:6/10 - (60%)
Similarity:7/10 - (70%) Gaps:0/10 - (0%)


- Green bases have known domain annotations that are detailed below.


Human    17 KDDEEEDPLD 26
            |.||:||..|
  Fly   537 KADEDEDSND 546

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E2F4NP_001941.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20 1/2 (50%)
E2F_TDP 18..83 CDD:460530 5/9 (56%)
Leucine-zipper 43..65
DEF box 48..85
Dimerization. /evidence=ECO:0000255 86..181
E2F_DD 95..198 CDD:271137
coiled coil 95..130 CDD:271137
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..340
Transactivation. /evidence=ECO:0000255 337..413
HCFC1-binding-motif (HBM) 389..392
Interaction with RBL1 and RBL2. /evidence=ECO:0000255 390..407
E2f1NP_001262809.1 E2F_TDP 256..318 CDD:460530
E2F_DD 327..444 CDD:473951
coiled coil 327..362 CDD:271137
Blue background indicates that the domain is not in the aligned region.

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