DRSC/TRiP Functional Genomics Resources

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Protein Alignment E2F4 and E2f2

DIOPT Version :10

Sequence 1:NP_001941.2 Gene:E2F4 / 1874 HGNCID:3118 Length:413 Species:Homo sapiens
Sequence 2:NP_477355.1 Gene:E2f2 / 35381 FlyBaseID:FBgn0024371 Length:370 Species:Drosophila melanogaster


Alignment Length:427 Identity:112/427 - (26%)
Similarity:167/427 - (39%) Gaps:128/427 - (29%)


- Green bases have known domain annotations that are detailed below.


Human     3 EAGPQAPPPPGTPSRHEK-----------SLGLLTTKFVSLLQEAKDGVLDLKLAADTLAVRQKR 56
            :..|..|.|..:||..:.           ||.|||.|||.|: :|.:|.:|||.|...|.| |||
  Fly    48 DTSPDPPTPIKSPSNSQSQSQPGQQRSVGSLVLLTQKFVDLV-KANEGSIDLKAATKILDV-QKR 110

Human    57 RIYDITNVLEGIGLIEK-KSKNSIQWKGVGPGCNTREIADKLIELKAEIEELQQREQELDQHKVW 120
            |||||||||||||||:| :..:.::|:  |.|.|..:..:.....::....|:..|.:||:...:
  Fly   111 RIYDITNVLEGIGLIDKGRHCSLVRWR--GGGFNNAKDQENYDLARSRTNHLKMLEDDLDRQLEY 173

Human   121 VQQSIRNVTEDVQNSCLAYVTHEDICRCFAGDTLLAIRAPSGTSLEVPIPEGLNGQKKYQIHLKS 185
            .|:::|.|.:|..|...||||.:|:...|..|::..|  |:... ||.|.     :..|::.:..
  Fly   174 AQRNLRYVMQDPSNRSYAYVTRDDLLDIFGDDSVFTI--PNYDE-EVDIK-----RNHYELAVSL 230

Human   186 VSG-PIEVLLVNKEAWSSPPVAVPVPPPEDLLQSPSAVSTPPPLPKPALAQSQEASRPNSPQLTP 249
            .:| .|::.||..:..|:                                            ..|
  Fly   231 DNGSAIDIRLVTNQGKST--------------------------------------------TNP 251

Human   250 TAVPGSAEVQGMAGPAAEITVSGGPGTDSKDSGELSSLPLGPTTLDTRPLQSSALLDSSSSSSSS 314
            ..|.|..:..                                 .|||            .|.|:|
  Fly   252 HDVDGFFDYH---------------------------------RLDT------------PSPSTS 271

Human   315 SSSSSNSNSSSSSGPNPST-----SFEPIKADPTGVLELPKELSEIFDPTRECMSSELLEELMSS 374
            |.||.:.|:.:.:| |..|     |..|...|...:||.......||   :..:|...|......
  Fly   272 SHSSEDGNAPACAG-NVITDEHGYSCNPGMKDEMKLLENELTAKIIF---QNYLSGHSLRRFYPD 332

Human   375 E---VFAPLLRLSPPPGDHDYIYNLDESEGVCDLFDV 408
            :   ...|||:|:||  ..|:.:.|...||:|:||||
  Fly   333 DPNLENPPLLQLNPP--QEDFNFALKSDEGICELFDV 367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E2F4NP_001941.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20 5/16 (31%)
E2F_TDP 18..83 CDD:460530 37/76 (49%)
Leucine-zipper 43..65 15/21 (71%)
DEF box 48..85 22/37 (59%)
Dimerization. /evidence=ECO:0000255 86..181 24/94 (26%)
E2F_DD 95..198 CDD:271137 26/103 (25%)
coiled coil 95..130 CDD:271137 7/34 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..340 18/133 (14%)
Transactivation. /evidence=ECO:0000255 337..413 23/75 (31%)
HCFC1-binding-motif (HBM) 389..392 0/2 (0%)
Interaction with RBL1 and RBL2. /evidence=ECO:0000255 390..407 6/16 (38%)
E2f2NP_477355.1 E2F_TDP 77..138 CDD:460530 37/64 (58%)
E2F_DD 159..>218 CDD:473951 19/61 (31%)

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