DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pik3c2a and Pi3K68D

DIOPT Version :9

Sequence 1:NP_035213.2 Gene:Pik3c2a / 18704 MGIID:1203729 Length:1686 Species:Mus musculus
Sequence 2:NP_001163420.1 Gene:Pi3K68D / 39329 FlyBaseID:FBgn0015278 Length:1876 Species:Drosophila melanogaster


Alignment Length:1965 Identity:608/1965 - (30%)
Similarity:928/1965 - (47%) Gaps:377/1965 - (19%)


- Green bases have known domain annotations that are detailed below.


Mouse     2 AQISNNSEFKQCSSSHPEPIRTKDVNKAEALQMEAEALAKLQKDRQMTDSPRGFELSSST----- 61
            |.|..:.:|:.            |:.||.||.:|..||...:::::...   |::.||:.     
  Fly     5 AHIDYDKQFQD------------DLAKATALSLEQHALDDYRRNKKYGS---GYQQSSTVAGRDY 54

Mouse    62 -----------------------------RQRTQGFNKQDYDLMVF-------PELDSQKRAVDI 90
                                         |.||......|.||:.|       ||..|....:..
  Fly    55 QAAQRSQSLHQPRRHSEVHQVAISPENAERSRTPPAQGTDNDLICFASPTSKQPESSSPFGKLIE 119

Mouse    91 DVEKLTQAELEKILLDDNFETRKPPALPVTPVLSPSFSTQLYLRPSGQR---------GQWPPGL 146
            |::::.....:..|            :|:.||.|.|...|....|..||         |....|:
  Fly   120 DLQRMQPTNPQSAL------------VPMGPVASASIPPQYGFPPHQQRPTAAQPTPYGMVAGGV 172

Mouse   147 CGPSTY----TLPSTYPSAYSKQATFQNGFSPRMPTFPSTESV--------YLRLPGQ--SPYFS 197
            .|...|    .:|  |..|..:|....:....|:.:.|:..:|        |:..||.  :|| :
  Fly   173 VGGPAYGDLQLVP--YQPAAQQQRPLNSEELQRLYSMPAQMAVVPVPQPNAYMYYPGAVVTPY-T 234

Mouse   198 YPLTPAT-----PFHPQ-----GSLPVYRPLVSPDMAKLFEKIASTSEF----LKNGKARTDLEI 248
            .|:.|.:     |.:|.     |....:..|..|......::.|.|:..    ..|....:..| 
  Fly   235 APIVPGSAAFMPPQYPAQGYGFGGAYTHMDLRRPQSQPAPQQTAPTTSHHHSQPSNHSTSSPAE- 298

Mouse   249 ANSKASVCNLQISPKSEDINKF----------------DWLDLDPLSKPKVDYVEVLEHEEEKKD 297
            ||..|.....|: |.:..::..                |.:||:.....:|..:|..       |
  Fly   299 ANGVAFPARRQV-PSTVGVSSSSHTGNNGHSSVPRRGNDLIDLNHEDYSRVSVLEAF-------D 355

Mouse   298 PVL---------------LAE-DPWDAVLLEERSP--SCHLERKVNGKSLSGATVTRSQSLI--- 341
            |:|               .|| ||:|.:...:.:.  |..:...||....:.|||:.:..||   
  Fly   356 PLLNDNTGNDTASDSTSYYAEYDPFDFLYSGDAATQYSDPMYEAVNRWDKTVATVSPNVGLIGWR 420

Mouse   342 --------IRTAQFTKA------------QGQVSQKDP--------------------------- 359
                    ..::|:..|            .|.:|...|                           
  Fly   421 QDFLSQPSTSSSQYGVAPPEESLKLAENGSGTISPPPPLPPRNQQCYESNQAAMPVSRPPQSSVL 485

Mouse   360 --NGTSSLPTG------------SSLLQEFEVQNDEVAAFCQSIMKLKTKFPYTDHCTNPGYLLS 410
              :.|||:|..            ..|:.:....:.|:..|...:.:::.::|:.|..||.|::::
  Fly   486 TDSYTSSIPANVVLDRRKTCTRLYELISDQRTDDPELLEFYHMVKEVRARYPHDDAPTNVGHVVA 550

Mouse   411 PVTVQRNMCGENASVKVSI-------------------EIEGLQLPVTFTCDVSSTVEIIIMQAL 456
            .......|.  :.|:||.:                   :::|..:|||||||:.|.|..::.|||
  Fly   551 AEFNYHYMM--DTSIKVIVHPALNTLQSTVLAASMGKEQVKGYGMPVTFTCDIDSVVAQVVAQAL 613

Mouse   457 CWVHDDLNQVDVGSYILKVCGQEEVLQNNHCLGSHEHIQNCRKWDTEIKLQL-LTLSAMCQNLAR 520
            ..:...:... |..|.:|..|..|.|.....|...|.:.|..:.:.::.|.| |:.:|..|.:||
  Fly   614 ASLEGQVKGT-VTDYAVKPIGLLEWLAPTSRLSQLECVHNSFQLEKDVHLGLCLSTAANMQAIAR 677

Mouse   521 TAEDDEAPVD-LNKYLYQIEKPYKEVMTRHPVEELLDSYHYQVELALQTENQHRAVD-------- 576
            |..|||...| |.::|  :......::|...:..|:::      |.::.:....|.|        
  Fly   678 TERDDEHDADLLPEHL--LPNEVVPIVTYDNMMILIET------LEMEIDKLESAADGVPGRSVV 734

Mouse   577 ---QVIKAVRKICSALDGVETPSVTEAVKKLKRAVNLPRNKSADVTSLSGSDTRKNSTKGSLNPE 638
               .|::||:.||:.|..::|..:...|..|||...:              :.:|.|| |:.|||
  Fly   735 SCSGVVQAVKAICALLGSIDTMEIARCVADLKRICEV--------------EQKKYST-GASNPE 784

Mouse   639 -------------------NPVQVSMDHLTTAIYDLLRLHANSSRC--STGCPRGSRNIKEAWTA 682
                               ..::|..:.|..|:.:|:.|:||..|.  |...|..|.........
  Fly   785 IVSDYGDYAQVVLRPRSMLEQIKVKCNELRDAVQELVELYANVFRVAFSVKTPDYSTTPIPISCV 849

Mouse   683 TEQLQFTVYAAHGISSNWVSNYEKYYLICSLSHNGKDLFKP-IQSKKVGTYKNFFYLIKWDELII 746
            ::.:...:...|....||  .::.|.|...:.:..:.|.|| :.:....|....|..:.:...:.
  Fly   850 SKPIVVCISCLHRPLPNW--KFDDYSLCVQIVYGTRLLSKPNVLTCSNDTSGGLFPRLNFSAWLT 912

Mouse   747 FPIQ-ISQLPLESVLHLTLFGVLNQSSGS-SPDSN-KQRKGPEALGKVSLTLFDFKRFLTCGTKL 808
            |... |..||.|:.|...|:|....|.|. :.|.| ::|:....||..|:.||||||.:.||..|
  Fly   913 FDQHPICTLPREARLTFVLYGKQAASEGEPNADQNGERRQVTTELGWCSIQLFDFKRVMICGPYL 977

Mouse   809 LYLW---TSSHTNSIP--GAIPKKSYVMERIVLQVDF-----------------PSPAFDIIYTS 851
            |.||   |.......|  |..|:..:..   ||.::.                 |:|.:|.    
  Fly   978 LSLWPPMTDKMLGPAPARGCHPQPDFCP---VLSIEVPPYGGRIEFPEHQEVPKPAPHYDF---- 1035

Mouse   852 PQIDRNIIQQDKLETLESDIKGKLLDIIHRDSSFGLSKEDKVFLWENRYYCLKHPNCLPKILASA 916
            ..:|.| :|::.|:|.|....|              :.|.:...||.|.|...:||.|||:|.:|
  Fly  1036 ASLDAN-LQEELLDTAELGYTG--------------ATERREVFWEKRLYLQSYPNALPKVLHAA 1085

Mouse   917 PNWKWANLAKTYSLLHQWPPLCPLAALELLDAKFADQEVRSLAVSWMEAISDDELADLLPQFVQA 981
            .:|.:|||...::|||.|.||.||.:||||..::.|.:||..||.|:..:.:|:|.|.|||.||:
  Fly  1086 HSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYPDAKVREKAVEWISKMPNDQLVDFLPQLVQS 1150

Mouse   982 LKYEIYLNSSLVRFLLSRALGNIQIAHSLYWLLKDALHDTHFGS--------------------- 1025
            ||::.|..|::.|||||:.|.:.:.||.:||||..:|.|....|                     
  Fly  1151 LKHDTYEGSAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGAAMVDQEYDESQVTQVRYY 1215

Mouse  1026 -RYEHVLGALLSVGGKGLREELSKQMKLVQLLGGVAEKVRQASGSTRQVVLQKSMERVQSFFLRN 1089
             |.:.:|.||:::.|:.:.:....|.::.|.|..:||.|::|..|.||..|...|:.|....|..
  Fly  1216 RRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEAKESMRQKSLAAGMDEVHQDLLEQ 1280

Mouse  1090 KCRLPLKPSLVAKELNIKSCSFFSSNAMPLKVTMVNADPLGEEINVMFKVGEDLRQDMLALQMIK 1154
            ...|||.|.|....:::::||:|:||.:|||:..|..|  .|.:..:||.|:||:||.|.:|:|:
  Fly  1281 PTCLPLGPELEVTGVSVRNCSYFNSNTLPLKINFVGPD--AESLPAIFKCGDDLQQDQLTIQLIR 1343

Mouse  1155 IMDKIWLKEGLDLRMVIFRCLSTGRDRGMVELVPASDTLRKIQVEYGVTGSFKDKPLAEWLRKYN 1219
            ||:|:||.|.|||:||.|.|:.||...||:|||..::||||||||.|:||||||:|:||||.|.|
  Fly  1344 IMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVSEAETLRKIQVECGLTGSFKDRPIAEWLGKQN 1408

Mouse  1220 PSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKR 1284
            ||..||:.|..||..||||..||||||||||||||||||:::||:||||||||||.|||||:|||
  Fly  1409 PSPLEYQSAVRNFTLSCAGYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKR 1473

Mouse  1285 DRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQ 1349
            ||.|||||||||||||||:||:..|..||||||:|:|::||..:|.|:.|:.|..:|:|.:.| .
  Fly  1474 DRTPFVLTSDMAYVINGGDKPSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVNS-N 1537

Mouse  1350 DLKYVRDALQPQTTDAEATIFFTRLIESSLGSIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPK 1414
            .::|||.||.|..::.||...|.::|:|||.|..|:||||:|||||:||:....:.| :|||.|:
  Fly  1538 AVQYVRRALLPSQSNPEAAATFAKMIQSSLKSWFTQFNFFLHNLAQMRFTPDEGSGE-LLSFVPR 1601

Mouse  1415 TYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGHLEPSFVFRTFDEFQELHNKLSIIFPL 1479
            .|:.:||||:|.|.|..:.|.|:.:|.|:|::.:.|.|..:|:.:||::.||.|.|.||.:.|||
  Fly  1602 KYTMQQDGRLKIVKVVCFQKHYSMEKFYMYILEVTRHGQPDPTHLFRSYREFTEFHQKLCMHFPL 1666

Mouse  1480 WKLPGFPNRMVLGRTHIKDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIA 1544
            .||...|..:.:||::||.||.||...:..:|:||.:||.::|..:||.|||||||||::...:.
  Fly  1667 VKLHSLPAGVHVGRSNIKSVAEKRLPLIQRFLKSLFDASEEIAHSELVYTFFHPLLRDQQEAKLG 1731

Mouse  1545 ----RSAGAVPFSPTLGQIGGAVKLSVSYRNGTLFIMVMHIKDL-VTEDGADPNPYVKTYLLPDT 1604
                :.....|......:| |.::||:.|:.|.|.:|:.|.|.| :.:.|.:||.|||.||.||.
  Fly  1732 MPKIKEVKQQPSRDNPHEI-GQIRLSLQYQRGVLTVMIHHAKGLPMLQGGQEPNTYVKCYLKPDP 1795

Mouse  1605 HKTSKRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGITLPLKDFN 1669
            .|.:|||||:.|||..|:|.|.|.|. .....:::|.||::|.|.::|:||..|||..:.|..::
  Fly  1796 KKETKRKTKVVRKTCVPSFMETLEYR-MPLNIIQERRLQVTVWSHDTLQENELLGGFDMDLSKYD 1859

Mouse  1670 LSKETVKWYQLTAAT 1684
            |.:|.|.||:|.|.:
  Fly  1860 LRQELVDWYRLGAVS 1874

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pik3c2aNP_035213.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 3/23 (13%)
Interaction with clathrin, sufficient to induce clathrin assembly. /evidence=ECO:0000250|UniProtKB:O00443 2..142 36/189 (19%)
ETS_PEA3_N <40..>210 CDD:368026 44/243 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 41..68 6/60 (10%)
PI3K_rbd 421..513 CDD:366310 28/111 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 615..640 7/43 (16%)
C2A_PI3K_class_II 677..849 CDD:175979 47/197 (24%)
PI3Ka_II 869..1038 CDD:238441 66/190 (35%)
PI3Kc_C2_alpha 1043..1395 CDD:270720 190/351 (54%)
PX_PI3K_C2_alpha 1426..1534 CDD:132822 44/107 (41%)
Interaction with PtdIns(4,5)P2-containing membranes. /evidence=ECO:0000269|PubMed:16338929 1488..1493 0/4 (0%)
C2B_PI3K_class_II 1560..1681 CDD:176027 51/121 (42%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O00443 1606..1617 6/10 (60%)
Pi3K68DNP_001163420.1 EIN3 <58..392 CDD:296674 66/357 (18%)
PI3K_rbd 561..669 CDD:197540 28/108 (26%)
C2A_PI3K_class_II 844..1021 CDD:175979 44/181 (24%)
PI3Ka_II 1038..1202 CDD:238441 68/178 (38%)
PI3Kc_II 1235..1583 CDD:270710 190/350 (54%)
PX_PI3K_C2_68D 1611..1721 CDD:132794 45/109 (41%)
C2B_PI3K_class_II 1751..1871 CDD:176027 51/120 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167836287
Domainoid 1 1.000 309 1.000 Domainoid score I1329
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20581
Inparanoid 1 1.050 816 1.000 Inparanoid score I474
Isobase 1 0.950 - 0 Normalized mean entropy S4067
OMA 1 1.010 - - QHG49277
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 1 1.000 - - FOG0001789
OrthoInspector 1 1.000 - - otm42389
orthoMCL 1 0.900 - - OOG6_104124
Panther 1 1.100 - - O PTHR10048
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3211
SonicParanoid 1 1.000 - - X2272
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1817.750

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