DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment K03A11.4 and CG31933

DIOPT Version :9

Sequence 1:	NP_510170.2	Gene:	K03A11.4 / 186918	WormBaseID:	WBGene00010521	Length:	664	Species:	Caenorhabditis elegans
Sequence 2:	NP_722734.1	Gene:	CG31933 / 326176	FlyBaseID:	FBgn0051933	Length:	673	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	135/524 - (25%)
Similarity:	222/524 - (42%)	Gaps:	85/524 - (16%)

- Green bases have known domain annotations that are detailed below.

Worm   179 QVIPKPPI-------EKPTIDISSLMQFDVFVILLDSLSYSQGRRALPRTLSYFTNHMDGVIFPY 236
            :::.|||.       ||.:...:|  ...|.::.|||:|:....|.:|||:.|...:|..|.|..
  Fly   182 KLLKKPPATLKYWDGEKHSSGATS--PISVMILGLDSVSHLNLLRQMPRTVRYMRQNMSQVEFWG 244

Worm   237 VNKVGENSRPNGIPIWFGKSLEKIDKTLLDEKVIPPDWPHKYFCKTYKDNETSLFSEFHDYGYRT 301
            .||:|.|:.||.|.:..|.|..:.:...:.:|.:              ||...::.||...||.|
  Fly   245 FNKIGTNTYPNLIALLTGLSAAESEAYWVRQKCM--------------DNLPLIWKEFKRAGYNT 295

Worm   302 LLAEDWADGTMNWPNCVGFENPPIDHFMRPFQNAYERKNHGTSLTQKHLNGK-----LCRETHHT 361
            ..|||.|..:|.:....||:.|..|:.:..|..........:|::..|..|:     :..|.:..
  Fly   296 SFAEDMAIYSMFYFGKPGFKRPTTDNNLHDFMVDLYINRQASSVSDTHCMGERAFMDILLEMNDR 360

Worm   362 LLDYMGQFTKAYPDQRKFGWVWAIDLGHNTENGFAHADKDFHNYLIKHRKALDE------SFVFI 420
            ||.:    |:.||   .|.:.|..:..|...|....||..|...|    ::||:      :.:|.
  Fly   361 LLPH----TQRYP---FFSFYWWANGFHEFFNSPRLADGRFERLL----RSLDDAGITNNTIIFF 414

Worm   421 LGDHGLRFGDVRKTFVGSLDVNNPFTALSIPKVLR-KTTKILEIMTENAKQIQSHYDTRATILDI 484
            :.|||||:|..|.:|.|.::.:.||.::..||.:| |....::.:..||..:.:.||...|:..|
  Fly   415 MSDHGLRWGLFRSSFQGMIEDSQPFLSVLYPKWMRLKYPMAIKSLVGNAHSLVTTYDLHETLKHI 479

Worm   485 MKYQSANSFSETM-PREIPGEKGSSYIRK----QPSTP-RNCRNMPVPLQYCICQFKKSKLPRNT 543
            ::..|....|.|. ..|:...|||...|.    .|..| |||....:|.::|:|. |:..:|.:.
  Fly   480 LEPSSLEDTSITQKTEELWKLKGSQTPRAVSLFLPIPPWRNCNTSHIPSKFCLCH-KQIPIPESN 543

Worm   544 TTAESIGKALATAVNTQIAEANFTKMCIKMEWEKTTSLLAY------DDKF---KG-ATLYS--- 595
            .........:...||..:.|   ..:||.::.:...|  ||      ||.|   || ..:|.
  Fly   544 RVVTKSASIIIDYVNQLMVE---YPVCIPLQLDSIES--AYFAAPQRDDDFYIEKGHKNVYPEKG 603

Worm   596 -------------VTAVMKEPSNAEFKGNVKIMNGEIKVLGMVERSNKYG-KTADCMKSEHHRPY 646
                         |..:..:|.||.|:|..:....::.::|.|.|....| :..||:.:....|:
  Fly   604 PFWKKQKYEDRDIVVRLKTKPGNAYFEGMTRRQGSKLSLVGEVVRVGGEGNRNNDCIDNPLLEPF 668

Worm   647 CYCA 650
            |:||
  Fly   669 CHCA 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
K03A11.4	NP_510170.2	DUF229	98..570	CDD:281053	108/415 (26%)
K03A11.4	NP_510170.2	ALP_like	199..488	CDD:293745	81/300 (27%)
CG31933	NP_722734.1	DUF229	114..576	CDD:281053	110/424 (26%)
CG31933	NP_722734.1	ALP_like	208..483	CDD:293745	81/299 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28588
OrthoDB	1	1.010	-	-		D306348at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.990