Protein Alignment Phex and Nepl11

DIOPT Version :10

• Sequence 1: NP_035207.1
• Gene: Phex / 18675
• MGIID: 107489
• Length: 749
• Species: Mus musculus
• Sequence 2: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Alignment Length: 750
• Identity: 151/750 - (20%)
• Similarity: 264/750 - (35%)
• Gaps: 216/750 - (28%)

Mouse    22 ALA-LFIGGTLVLGTLLFLVSQGLLSFQAKQEYCLKPECIEAAAAIMSKVNLSVDPCENFFRFAC 85
            ||| |:|.|.......|..|...||||    .:.|:|           .::.|..||::|:.:.|
  Fly     5 ALAVLWIAGIAYGQDDLLRVETELLSF----SHNLEP-----------YLDTSKQPCQDFYGYVC 54

Mouse    86 DGWISNNPIPEDMPSYGVYPWLRHNVDL------KLKALL-EKSVSRRRDTEAVQKAKILYSSCM 143
            .                      |:.:|      :.::|| |..|::..|.| :|... .:.||.
  Fly    55 S----------------------HSANLSETGRQRFQSLLKETDVAQLMDME-LQLIN-FFKSCE 95

Mouse   144 NEKAIEKADAKPLLHILRHSPFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYV 208
            :.:.:|......|   .|.|. .||.||    |..|.:.::.:..|......|.:........:.
  Fly    96 SGRGVEALKGSQL---YRQSG-GWPSLE----PNKVNASQRTNQTQRWLGLLGYFHEVGAPYFFE 152

Mouse   209 SPDDKASNEHILKLDQATLSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLL---GANSSRAEHD 270
            :.....||:.::.|..            |.|.     |:.|.||......:|   |...|||...
  Fly   153 TSVTMQSNKRLVVLQP------------DGTR-----RNTLRKFEQRVGEVLQSFGIEQSRAHVT 200

Mouse   271 MKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISEL---SAMIPQFDWLGYIKKVIDTRLYPHLKD 332
            ...||.||....:| :..::...:..::..|...:   :|.:.:.||.||.:|::..      |.
  Fly   201 ALEVLSLERSRRDI-VKADHVEDQVQFSYGNFKRIVFGNASLIRLDWDGYFRKLLGG------KT 258

Mouse   333 IGPSENVVVRVPQYFKDLFRILGAERKKTIANYLVWR-----MVYSRIPNLSRRFQYRWLEFSRV 392
            ...|:.:||:......:.|.:|.......:.|: :|.     :|.:....||.  .|....::.|
  Fly   259 PQASDTIVVKQLPRLVEYFALLQNTSMVRLLNW-IWTDYLMDIVDADCHQLSE--TYAGDLYAHV 320

Mouse   393 IQGTTTLLPQWDKCVNFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWM 457
            :|..|         .|.:|.|                   :|..||.:    |:.|.| ..:.|:
  Fly   321 VQRVT---------ANRVELA-------------------QMYSELGK----AYTDQL-GGSVWI 352

Mouse   458 DAGTKRKAQEKARAVLAKVGYPEFIMNDTYVNEDLKAIKFSESDYFGNVLQTRKY-----LAQSD 517
            |    ..:::.:|..|..:.:.. :..|..::....:|.......:.|:.:.||:     ||...
  Fly   353 D----EISRQSSRQFLGNIMHTT-LNGDERLDAAYHSILLGRRSLYRNLEKLRKFQRTRRLASHS 412

Mouse   518 FFWLRKAVPKTEWFTNPTTVNAF---YSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVG 579
            ...:|:   ..:.|   ..||||   ::.||                      .|:|    :::|
  Fly   413 AQQVRR---YAQMF---APVNAFLGQHNLST----------------------PLNY----LLLG 445

Mouse   580 HEFTHGFDNNGRKYDKNGNLDPWWSVESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRT----- 639
            ..|:......|......|   .|.|.:||.:|....:|:                 ||:|
  Fly   446 EFFSRSLVAAGSSSRTQG---AWRSSDSERRFAIFQQCV-----------------GKQTNAIDL 490

Mouse   640 LGENIADNGGLREAFRAYRKWINDRR---QGVEEPLLPGIT-FTNNQLFFLSYAHVRCNSYRPEA 700
            |...:|.    |:|..||.:|:..:.   :.|:..|..|.: .:..:|||::...|.|.|
  Fly   491 LLSLLAQ----RQALSAYGQWLATQAGLVERVDAVLAAGSSKMSLQRLFFVTSLLVDCRS----- 546

Mouse   701 AREQVQIGAHSPPQFR--VNGAISNFEEFQKAFNC 733
                 ::||....:.|  .:..:.|..||.:||.|
  Fly   547 -----ELGALQQDRKRQVTHATLRNSPEFLEAFRC 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phex	NP_035207.1	M13	74..740	CDD:341056	135/696 (19%)
Nepl11	NP_649449.1	GluZincin	45..590	CDD:472708	135/694 (19%)