DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex16 and Pex16

DIOPT Version :9

Sequence 1:	NP_660104.2	Gene:	Pex16 / 18633	MGIID:	1338829	Length:	336	Species:	Mus musculus
Sequence 2:	NP_649252.1	Gene:	Pex16 / 40293	FlyBaseID:	FBgn0037019	Length:	341	Species:	Drosophila melanogaster

Alignment Length:	354	Identity:	126/354 - (35%)
Similarity:	204/354 - (57%)	Gaps:	34/354 - (9%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MEKLRLLSLRYQEYVTRHPAATAQLETAVRGLSYLLAGRFSDSHELSELVYSASNLLVLLNDGIL 65
            |:.|:.:...|:.:|.::|......||..:.:||.:|||.|.|:.:|||||:.||:||..||.|:
  Fly     1 MDTLKGMLKAYEAWVGKNPDVVGDFETTAKWVSYFIAGRISSSNVVSELVYTLSNMLVFYNDRII 65

Mouse    66 RK----------ELRKKLPVSLSQQKLLTWLSVLECVEVFMEMGAAKVWGEVGRWLVIALIQLAK 120
            .|          .|:.||     ..:|...|:.||..|||:|:.|.:::|:.|:||||||||..|
  Fly    66 EKARNSEENSVIHLQSKL-----CYRLKVTLTTLEYSEVFIEISARRLFGQSGKWLVIALIQAFK 125

Mouse   121 AVLRMLLLIWFKAGIQTSPPIVPLDRETQAQPLDGDHNPGSQEP--------SYVGKRSHRVVRT 177
            |..|..:|....:.|.|||||..|:|..:.:...||....|...        ::..|||.||:|.
  Fly   126 AAGRFFILKHSTSDIITSPPIAALNRRAKQRKNSGDGVASSTNDLLQSQHSITFQLKRSGRVIRK 190

Mouse   178 LQNSPSLHSRYWGAPQQREIRQKQQQEELSTPPTPLGLQETIAESLYIARPLLHLLSLGLWGQRS 242
            ::.:|.|        |.|:.:......|.:....|..|.:  ||.|||::||:||:::||:|:||
  Fly   191 VEGAPPL--------QYRDFKLHIDNNEAAKTQIPRKLLQ--AEYLYISKPLIHLVAMGLFGRRS 245

Mouse   243 WTPWLLSGVVDMTSLSLLSDRKNL-TRRERLELRRRTILLLYYLLRSPFYDRFSEAKILFLLQLL 306
            |..::::..:|:.|:.|....::| :::::|||.||.|.::|:|:||||||.|:::::..:|..:
  Fly   246 WKQYMVALSIDLYSIHLYRQHRDLMSKQQKLELSRRCINIMYFLVRSPFYDSFTKSRLERILDFV 310

Mouse   307 TDHIPGVGLVARPLMDYLPSWQKIYFYSW 335
            ...:|...:||:||.||:|:||..|||.|
  Fly   311 ATSVPIAKVVAKPLKDYIPTWQSTYFYLW 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex16	NP_660104.2	Pex16	11..329	CDD:312205	119/336 (35%)
		Required for peroxisomal location. /evidence=ECO:0000250\|UniProtKB:Q9Y5Y5	66..81		4/24 (17%)
		Interaction with PEX19. /evidence=ECO:0000250\|UniProtKB:Q9Y5Y5	221..336		48/116 (41%)
Pex16	NP_649252.1	Pex16	11..333	CDD:285774	121/340 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845823
Domainoid	1	1.000	203	1.000	Domainoid score	I2966
eggNOG	1	0.900	-	-		E1_KOG4546
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3537
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3597
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58411
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006249
OrthoInspector	1	1.000	-	-		oto94041
orthoMCL	1	0.900	-	-		OOG6_103805
Panther	1	1.100	-	-	LDO	PTHR13299
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5562
SonicParanoid	1	1.000	-	-		X5194
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790