DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Per2 and per

DIOPT Version :10

Sequence 1:NP_035196.2 Gene:Per2 / 18627 MGIID:1195265 Length:1257 Species:Mus musculus
Sequence 2:NP_525056.2 Gene:per / 31251 FlyBaseID:FBgn0003068 Length:1218 Species:Drosophila melanogaster


Alignment Length:1354 Identity:279/1354 - (20%)
Similarity:465/1354 - (34%) Gaps:384/1354 - (28%)


- Green bases have known domain annotations that are detailed below.


Mouse     8 SPSPTSPTKEPGAPQPTQA-----VLQEDVDMSSGSSGNENCSTGRDSQGSDCDDNGKELRMLVE 67
            |.|.:|.:...|....|||     :::.:.|.|.....|:....|           ..:.:.|:.
  Fly    40 SGSHSSGSSGYGGKPSTQASSSDMIIKRNKDKSRKKKKNKGAGQG-----------AGQAQTLIS 93

Mouse    68 SSNTHPSPDDAFRLMMTEAEHNPSTSGCSSEQSAK-------ADAHKELIRTLKELKVHLPADK- 124
            :|.:....|        |.:..||.:||..:|..:       .:.|.| .:.:::|:.....|: 
  Fly    94 ASTSLEGRD--------EEKPRPSGTGCVEQQICRELQDQQHGEDHSE-PQAIEQLQQEEEEDQS 149

Mouse   125 -------KAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSESQPCSVDVPSYSM--------- 173
                   :.:|.|.:.|...:.:.|                    |.||.:...||         
  Fly   150 GSESEADRVEGVAKSEAAQSFPIPS--------------------PLSVTIVPPSMGGCGGVGHA 194

Mouse   174 ---------------------EQVEGITSEYI--------VKNADMFAVAVSLVSGKILYISNQV 209
                                 |.:.|:.:...        ||. |.|...:|:..|.:||.:..:
  Fly   195 AGLDSGLAKFDKTWEAGPGKLESMTGVGAAAAGTGQRGERVKE-DSFCCVISMHDGIVLYTTPSI 258

Mouse   210 ASIFHCKKDAFSDAKFVEFLAPHDVSVFHSYTTPYKLPPWSVCSGL---DSFTQECMEEKSFFCR 271
            ..:....:|.:....|::|:...|.:.|.|..|          :|:   :|......:.||.|| 
  Fly   259 TDVLGYPRDMWLGRSFIDFVHLKDRATFASQIT----------TGIPIAESRGSVPKDAKSTFC- 312

Mouse   272 VSVGKHH----------ENEIRYQPFRMTPYLVKVQEQQGAE-------SQLCCLLLAERVHSGY 319
            |.:.::.          ...:.|:|||:.....:..|:...:       :.:..::.|..:.|.|
  Fly   313 VMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMVSNGTNMLLVICATPIKSSY 377

Mouse   320 EAPR--IPPEKRIFTTTHTPNCLFQAVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKK 382
            :.|.  :..:...|...||...:...||..||..|||||||||...::...|..|..:|...::.
  Fly   378 KVPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYET 442

Mouse   383 ILQAG---GQPFDYSPIRFRTRNGEYITLDTSWSSFINPWSRKISFIIGRHKVRVGPLNEDVFAA 444
            :::.|   |..|...|.||..:||.|:.|:|.|:||:||||||:.|::|.|:|..||...:||.|
  Fly   443 VMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEFVVGHHRVFQGPKQCNVFEA 507

Mouse   445 SPCPEEKTPHPSVQELT---EQIHRLLMQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSNGQEE 506
            :|..:.|....:....|   |.|.:.|.:.|                       :..||:..||.
  Fly   508 APTCKLKISEEAQSRNTRIKEDIVKRLAETV-----------------------SRPSDTVKQEV 549

Mouse   507 SHRRRSGIFKTSGKIQTKSHVSHESGGQKEASVAEMQSSPPAQVKAVTTIERDS--SGASLPKAS 569
            |.|             .::..|.......|.|.|:::...|.: ..:|..||||  .|...|...
  Fly   550 SRR-------------CQALASFMETLMDEVSRADLKLELPHE-NELTVSERDSVMLGEISPHHD 600

Mouse   570 FPEELAYKNQPPCSYQQISCLDSVIRYLESCSEAATLKRKCEFPANIP---------SRKATVSP 625
            :.:..:....|| ||.|::..::::|:..  |:..|...:.:.|...|         .....:||
  Fly   601 YYDSKSSTETPP-SYNQLNYNENLLRFFN--SKPVTAPAELDPPKTEPPEPRGTCVSGASGPMSP 662

Mouse   626 GLHSGEAARPSKVTSHTEVSAHLSSLTL------------------PGKAESVVSLTSQCSYSST 672
             :|.|.....|.....|..:.|:||:|.                  .|......:.|...:.:.|
  Fly   663 -VHEGSGGSGSSGNFTTASNIHMSSVTNTSIAGTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT 726

Mouse   673 IVHVGDKKPQPELETVEDMASGPESLDGAAGGLSQEKG---PLQKLGLTKEVLAAHTQREEQGFL 734
            ....|         |.....:|..|..| .|..|..||   .:..:.||:.:|..|....|:..|
  Fly   727 GTGTG---------TGTGTGNGTNSGTG-TGTASSSKGGSAAIPPVTLTESLLNKHNDEMEKFML 781

Mouse   735 QRFREVSRLSALQAHCQNYLQERSRAQASD-----------RGLRNTSGLESSWKKTGKNRKLKS 788
            ::.||          .:....|:|:..|:|           .|::.  |...||:  |:..|.|.
  Fly   782 KKHRE----------SRGRTGEKSKKSANDTLKMLEYSGPGHGIKR--GGSHSWE--GEANKPKQ 832

Mouse   789 KRVKTRDS-------------SESTGSGG----------------PVSHRPPLMGL--------- 815
            :.....|:             :...||||                |........|.         
  Fly   833 QLTLGTDAIKGAAGSAGGAVGTGGVGSGGAGVAGGGGSGTGVAGTPEGRATTTSGTGTPGGAGGG 897

Mouse   816 -NATAWSPSDTSQSSCPSAPFPTAVPAYPLPVFQAPGIVSTPGTV-VAPPA-ATHTGFTMPVVPM 877
             .|.|.:.:..|.|...|.|.|::.|.....:...|     |.:| :.||. :|||..       
  Fly   898 GGAGAAAAAGASSSVGSSTPGPSSYPTCTQNINLWP-----PFSVGITPPVHSTHTAM------- 950

Mouse   878 GTQPEFAVQPLPFAAPLAPVMAFMLPSYPFPPA--TPNLPQAFLPSQPHFPAHPTLASEITPASQ 940
             .|..|:             .|.:.|::.:.||  ||..|    ...|....||.......|.: 
  Fly   951 -AQSSFS-------------SAGLFPTFYYIPASLTPTSP----TRSPRMHKHPHKGGTDMPTT- 996

Mouse   941 AEFPSRTSTLRQPCACPVTPPAGTVALGRASPPLFQSRGSS-------------PLQLNLLQLEE 992
                |:.:......|.|:...||.:   ...|.||.:..::             |...|.||:.|
  Fly   997 ----SQQAAAAAAQAMPLQYMAGVM---YPHPSLFYTHPAAAAATAMMYQPMPFPGMANALQIPE 1054

Mouse   993 APEGSTGAAGTLGTTGTAASGLDCTSG------TSRDRQPKAPPTCNEPSDTQNSDAIS------ 1045
            .|.||..|......|.|.||......|      |....|..:..:.:..::..:|.|:|      
  Fly  1055 RPLGSQSAYNKSVYTTTPASMTKKVPGAFHSVTTPAQVQRPSSQSASVKTEPGSSAAVSDPCKKE 1119

Mouse  1046 -TSSDLLNLLLG----EDLCSATGSALSRSGASATSDSLGSSSLGFGTSQSGAGSSDTSHTSKYF 1105
             ..|..:..::|    :..||::..|.::....:.           |.|....|||.:|..|.:.
  Fly  1120 VPDSSPIPSVMGDYNSDPPCSSSNPANNKKYTDSN-----------GNSDDMDGSSFSSFYSSFI 1173

Mouse  1106 GSIDSSENNHKAKMIPDTEESEQFIKYVLQDPIWLLMANTDDSIMMTYQLPSRD 1159
            .:.|.||:.      ||||:..:..|        |...:|.:|.:|.:  |..|
  Fly  1174 KTTDGSESP------PDTEKDPKHRK--------LKSMSTSESKIMEH--PEED 1211

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Per2NP_035196.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..60 11/56 (20%)
Nuclear export signal 1. /evidence=ECO:0000269|PubMed:11889036 109..118 1/8 (13%)
LXXLL 306..310 0/3 (0%)
PAS_3 344..428 CDD:430001 37/86 (43%)
PRK10263 <445..>982 CDD:236669 120/638 (19%)
Nuclear export signal 2. /evidence=ECO:0000269|PubMed:11889036 460..469 3/11 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 471..565 18/95 (19%)
Important for protein stability. /evidence=ECO:0000250|UniProtKB:Q9Z301 478..482 0/3 (0%)
CSNK1E binding domain. /evidence=ECO:0000269|PubMed:14701732 510..709 42/227 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 617..638 6/29 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..832 21/124 (17%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:11889036 778..794 3/15 (20%)
PHA03247 <790..1038 CDD:223021 60/309 (19%)
Interaction with PPARG. /evidence=ECO:0000269|PubMed:21035761 882..1067 43/216 (20%)
Nuclear export signal 3. /evidence=ECO:0000269|PubMed:11889036 983..990 2/6 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 994..1044 12/55 (22%)
Period_C 1040..1210 CDD:463464 29/131 (22%)
LXXLL 1051..1055 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1070..1115 10/44 (23%)
CRY binding domain. /evidence=ECO:0000250|UniProtKB:Q9Z301 1157..1257 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1224..1257
perNP_525056.2 PAS 238..333 CDD:395786 20/105 (19%)
PAS 388..495 CDD:238075 42/106 (40%)
Blue background indicates that the domain is not in the aligned region.

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