DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment duox-2 and Duox

DIOPT Version :9

Sequence 1:	NP_490684.1	Gene:	duox-2 / 186188	WormBaseID:	WBGene00018771	Length:	1503	Species:	Caenorhabditis elegans
Sequence 2:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster

Alignment Length:	1533	Identity:	650/1533 - (42%)
Similarity:	922/1533 - (60%)	Gaps:	88/1533 - (5%)

- Green bases have known domain annotations that are detailed below.

Worm    14 SLPLEIKVQFSKETLFSALQQEAETQRYDGWYNNLANSEWGSAGSRLHRDARSYYSDGVYSV-NN 77
            |..||:......|.::|    :.|.|||||||||||:.:|||..|.|.|.|...||||||:: ..
  Fly    49 SYGLELGSVHCYEKMYS----QTEKQRYDGWYNNLAHPDWGSVDSHLVRKAPPSYSDGVYAMAGA 109

Worm    78 SLPSARELSDILFKGESGIPNTRGCTTLLAFFSQVVAYEIMQSNGVSCPLETLKIQVPLCDNVFD 142
            :.||.|.||.:..:|:.|:.:....|.|||||.|:||.||:.::...||:|..:|::..||.::|
  Fly   110 NRPSTRRLSRLFMRGKDGLGSKFNRTALLAFFGQLVANEIVMASESGCPIEMHRIEIEKCDEMYD 174

Worm   143 NECEGKTTIPFYRAKYDKATGNGLNSPREQINERTSWIDGSFIYGTTQPWVSALRSFKQGRLAEG 207
            .||.|...|||:||.||:.||...|:||||||:.|:||||||||.|::.|::|:|||..|.|...
  Fly   175 RECRGDKYIPFHRAAYDRDTGQSPNAPREQINQMTAWIDGSFIYSTSEAWLNAMRSFHNGTLLTE 239

Worm   208 VPGYPPLNNP-HIPL-NNPAPPQVHRLMSPDRLFMLGDSRVNENPGLLSFGLILFRWHNYNANQI 270
            ..|..|:.|. .:|| |||. |.|.:::||:|||:|||.|.|:||.:|||.::..||||..|.:|
  Fly   240 KDGKLPVRNTMRVPLFNNPV-PSVMKMLSPERLFLLGDPRTNQNPAILSFAILFLRWHNTLAQRI 303

Worm   271 YREHPDWTDEQIFQAARRLVIASMQKIIAYDFVPGLLGEDVRLSNYTKYMPHVPPGISHAFGAAA 335
            .|.||||:||.|:|.||..||||:|.:|.|:::|..||  ..|..|..|...:.|||.|.|.|||
  Fly   304 KRVHPDWSDEDIYQRARHTVIASLQNVIVYEYLPAFLG--TSLPPYEGYKQDIHPGIGHIFQAAA 366

Worm   336 FRFPHSIVPPAMLLRKRGNKCEFRTEVGGYPALRLCQNWWNAQDIVKEYSVDEIILGMASQIAER 400
            |||.|:::||.  :.:|..:|.|:....||||:|||..||::.....:.||:|:::|:||||:||
  Fly   367 FRFGHTMIPPG--IYRRDGQCNFKETPMGYPAVRLCSTWWDSSGFFADTSVEEVLMGLASQISER 429

Worm   401 DDNIVVEDLRDYIFGPMHFSRLDVVASSIMRGRDNGVPPYNELRRTFGL-APKTWETMNEDFYKK 464
            :|.::..|:||.:||||.|:|.|:.|.:||||||||:|.||..|.::|| ..|||..:|...::.
  Fly   430 EDPVLCSDVRDKLFGPMEFTRRDLGALNIMRGRDNGLPDYNTARESYGLKRHKTWTDINPPLFET 494

Worm   465 HTAKVEKLKELYGGNILYLDAYVGGMLEG-GENGPGEMFKEIIKDQFTRIRDGDRFWFENKLNRL 528
            ....::.|||.|...:..:|.|||||||. |:  |||.|..:||:||.|:||.|||||||:.|.:
  Fly   495 QPELLDMLKEAYDNKLDDVDVYVGGMLESYGQ--PGEFFTAVIKEQFQRLRDADRFWFENERNGI 557

Worm   529 FTDEEVQMIHSITLRDIIKATTDIDETMLQKDVFFFKEGDPCPQPFQVNTIGLEPCAPLIQSTYW 593
            ||.||:..:..|||.|||..:||:.|..:|||||.::.|||||||.|:|...||||..|....|:
  Fly   558 FTPEEIAELRKITLWDIIVNSTDVKEEEIQKDVFMWRTGDPCPQPMQLNATELEPCTYLEGYDYF 622

Worm   594 DDNDTTYIYTLIGLACIPLICYSIGHYMVE------RRIRIGHNSACDSLTTDFSTESPKVNVYK 652
            ..::..:||..:.|..:|::|...|:.:|:      ||::|...:        ......|.:|.|
  Fly   623 SGSELMFIYVCVFLGFVPILCAGAGYCVVKLQNSKRRRLKIRQEA--------LRAPQHKGSVDK 679

Worm   653 VNALEWLQEEYIRQVRIEI--ENTTLTVKKPRGGILRKIRFETGQKIEVFH-------SIPNPSA 708
            :.|.|||...:.|.|.::.  |....||.:            .|:|:..|.       |:...:.
  Fly   680 MLAREWLHANHKRLVTVKFGPEAAIYTVDR------------KGEKLRTFSLKHIDVVSVEESAT 732

Worm   709 MH---GPFVLLSQKNNHHLVIRLSSDRDLSKFLDQIRQAASGINAEVIIKDEENSILLSQAITKE 770
            .|   .|::||...::|.||:.|.|.....||:.::.........|:.:.:....|:|::|.|:|
  Fly   733 NHIKKKPYILLRVPSDHDLVLELESYGARRKFVKKLEDFLLLHKKEMTLMEVNRDIMLARAETRE 797

Worm   771 RRQDRLDLFFREAYAKAFN---DSELQDSETSFDSSNDDILNETISREELASAMGMKANNEFVKR 832
            |||.||:.|||||||..|.   ....:.|:.|.|.....::..::|:.|.|:|:|||.|:.||::
  Fly   798 RRQKRLEYFFREAYALTFGLRPGERRRRSDASSDGEVMTVMRTSLSKAEFAAALGMKPNDMFVRK 862

Worm   833 MFAMTAKHNEDSLSFNEFLTVLREFVNAPQKQKLQTLFKMCDLEGKNKVLRKDLAELVKSLNQTA 897
            ||.:..|..:..:||.|||..:..|.......||:.:|.|||.:....:.:.:|:|:::||.:.|
  Fly   863 MFNIVDKDQDGRISFQEFLETVVLFSRGKTDDKLRIIFDMCDNDRNGVIDKGELSEMMRSLVEIA 927

Worm   898 GV------HITESVQLRLFNDV--LHKSGVSDDAEYLTCNNFDALFSEI-SDVQPIGLPFN--RK 951
            ..      .:||.:. .:|.||  .||:       :||..:|..:..|. .|...|||...  ::
  Fly   928 RTTSLGDDQVTELID-GMFQDVGLEHKN-------HLTYQDFKLMMKEYKGDFVAIGLDCKGAKQ 984

Worm   952 NYNSHIKEPSCHTSF---PIVDHSTPAPLSLIQRICAFLETYRQHVFIIFCFVAINIVLFFELFW 1013
            |:.......:..|||   |:.|......|:.......|||..||::|.:|.|..:.||||.|.|.
  Fly   985 NFLDTSTNVARMTSFNIEPMQDKPRHWLLAKWDAYITFLEENRQNIFYLFLFYVVTIVLFVERFI 1049

Worm  1014 HSRYLNEDRDLRRVMGAGIAITLSSAGALSFCMALILLTVCRNIITLLRETVIAQYIPFDSAIAF 1078
            |..::.|..|||.:||.|||||..||.:||||.:|:|||:.||:||.|:|..|.||||.||.|.|
  Fly  1050 HYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLITKLKEFPIQQYIPLDSHIQF 1114

Worm  1079 HKIVALFTLFWSTLHTIGHCVNFYHVGTQSDRGLACLFQETFFGSDVVPTLSYWFYGTITGLTGI 1143
            |||.|...||:|.|||:||.||||||.|||...|.||.:|..|.||..|.:::|.:.|:||.||:
  Fly  1115 HKIAACTALFFSVLHTVGHIVNFYHVSTQSHENLRCLTREVHFASDYKPDITFWLFQTVTGTTGV 1179

Worm  1144 GLVIVMSIIYVFALPKFTRRAYHAFRLTHLLNIGFYALTILHGLPSLFGSPKFGYYVVGPIVLFV 1208
            .|.|:|.||:|||.|...::||:.|...|.|.||.|.|:::|||..|.|.|:|..:.:||.:::.
  Fly  1180 MLFIIMCIIFVFAHPTIRKKAYNFFWNMHTLYIGLYLLSLIHGLARLTGPPRFWMFFLGPGIVYT 1244

Worm  1209 IDRIIGLMQYYKSLDIAHAEILPSDIIYIEYRRPREFEYKSGQWITVSSPSISCTF---NESHAF 1270
            :|:|:.|...|.:||:...::||||:|.|::.||...:|.||||:     .:|||.   :|.|:|
  Fly  1245 LDKIVSLRTKYMALDVIDTDLLPSDVIKIKFYRPPNLKYLSGQWV-----RLSCTAFRPHEMHSF 1304

Worm  1271 SIASSPQDENMKLYIKAVGPWTWKLRSELIRSLNTGSPFPLIHMKGPYGDGNQEWMNYEVAIMVG 1335
            ::.|:|.:..:..:|||.||||||||:............|.|.::||:|.|||:|..:|||:|||
  Fly  1305 TLTSAPHENFLSCHIKAQGPWTWKLRNYFDPCNYNPEDQPKIRIEGPFGGGNQDWYKFEVAVMVG 1369

Worm  1336 AGIGVTPYASTLVDLVQKTSSDSFHRVRCRKVYFLWVCSSHKNFEWFVDMLKNVENQAKPGILET 1400
            .|||||||||.|.|||..||::.:..|.|:||||||:|.|||:||||:|:|::||.:....:||.
  Fly  1370 GGIGVTPYASILNDLVFGTSTNRYSGVACKKVYFLWICPSHKHFEWFIDVLRDVEKKDVTNVLEI 1434

Worm  1401 HIFVTQMFHKFDLRTTMLYICEKHFRATNSGISMFTGLHAKNHFGRPNFKAFFQFIQSEHKEQSE 1465
            |||:||.|||||||||||||||.||:.. |..|:||||.|.||||||:..:|.:|:|.:|...|:
  Fly  1435 HIFITQFFHKFDLRTTMLYICENHFQRL-SKTSIFTGLKAVNHFGRPDMSSFLKFVQKKHSYVSK 1498

Worm  1466 IGVFSCGPVNLNESIAEGCADANRQRDAPSFAHRFETF 1503
            ||||||||..|.:|:...|.:.|:.|..|.|.|.||.|
  Fly  1499 IGVFSCGPRPLTKSVMSACDEVNKTRKLPYFIHHFENF 1536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
duox-2	NP_490684.1	An_peroxidase	39..552	CDD:281139	249/517 (48%)
		dual_peroxidase_like	41..596	CDD:188652	269/559 (48%)
		FRQ1	792..>895	CDD:227455	32/102 (31%)
		Ferric_reduct	1041..1182	CDD:280043	75/140 (54%)
		NOX_Duox_like_FAD_NADP	1224..1408	CDD:99783	89/186 (48%)
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139	248/516 (48%)
		dual_peroxidase_like	72..625	CDD:188652	269/559 (48%)
		EFh	827..882	CDD:238008	19/54 (35%)
		EFh	860..921	CDD:238008	18/60 (30%)
		EF-hand_7	860..920	CDD:290234	18/59 (31%)
		EFh	895..966	CDD:238008	21/78 (27%)
		EF-hand_7	899..965	CDD:290234	19/73 (26%)
		Ferric_reduct	1084..1217	CDD:280043	71/132 (54%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	142/276 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166238
Domainoid	1	1.000	520	1.000	Domainoid score	I152
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9689
Inparanoid	1	1.050	1220	1.000	Inparanoid score	I90
Isobase	1	0.950	-	0	Normalized mean entropy	S4061
OMA	1	1.010	-	-		QHG46390
OrthoDB	1	1.010	-	-		D19296at33208
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	1	1.000	-	-		otm14415
orthoMCL	1	0.900	-	-		OOG6_100242
Panther	1	1.100	-	-	O	PTHR11972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R458
SonicParanoid	1	1.000	-	-		X184
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750