DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Etv4 and Ets96B

DIOPT Version :9

Sequence 1:	XP_006532521.1	Gene:	Etv4 / 18612	MGIID:	99423	Length:	533	Species:	Mus musculus
Sequence 2:	NP_996290.1	Gene:	Ets96B / 42952	FlyBaseID:	FBgn0039225	Length:	640	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	162/526 - (30%)
Similarity:	217/526 - (41%)	Gaps:	133/526 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse    24 LPPPS-----QVSASARGPGPVAGGSGRMERRMKGGYLDQRVPYTFCSQKSPGNGSLGEALMVPQ 83
            :|||.     .:..|:..|.|:|..:                   ..:..:.|:.|.|.|
  Fly   130 IPPPPPPCCLTLGESSSSPNPIATAA-------------------LMNASTSGSSSAGGA----- 170

Mouse    84 GKLMDPGSLPPSDSEDLFQDLSHFQETWLA---------EAQVPD------------SDEQFVPD 127
                         |..|..||:. :.:|.|         ..|:||            :..:|..|
  Fly   171 -------------SASLCNDLTR-ESSWYAHHHHHHHHHHHQLPDELVMYATPTPTPAIGKFGLD 221

Mouse   128 FHSE---NLAFHSPTTRIKKEPQSPRTD-PALSCSRKPPLPYHHGEQCLYSSAYDSPRQIAIKSP 188
            ..:|   |..::.....::.:..|...| ||::.....|.|:.|.....|...:.|       ||
  Fly   222 TSTEGYLNARYNVNVKGVRHDRTSSFFDIPAVTHPHNHPHPHPHPHPHPYCYRFPS-------SP 279

Mouse   189 APGAPGQSPLQPFSRAEQQQSLLRASSSSQSHPGHGYLGEH----SSVFQQPVDMCHSFTSPQGG 249
            ..|...:|..:..|.|.....:    ||.|..|.|..: ||    ::..||...........|
  Fly   280 PAGILKKSDEEATSAAVYCSDV----SSGQHFPHHTKI-EHADSTTTAAQQQQQQQEQQQQQQ-- 337

Mouse   250 GREPLPAPYQHQLSEPCPPYPQQNFKQEYHDPLYEQAGQPASSQGGVSGHRYP-GAGVVIKQERT 313
             ::.....:|.||.:....:|..:.....|.. ::||.|.|.:      |..| .|....|...|
  Fly   338 -QQQQQQQHQQQLQQAAALHPHHHHSHHGHHG-HQQAEQQALT------HLTPLHAASAFKFSHT 394

Mouse   314 DFAYDSDVPGCASMYLHPEGFSGPS-----------------------PGDGVMGYGYEKSLRPF 355
            .....|.|....|.|.|.:.....|                       |.:..:...|..:|||
  Fly   395 AVISSSAVYATPSHYAHQQQTQSQSVYRDLSPTTLAAVSDADLKYDSGPYNAAISSTYPSALRP- 458

Mouse   356 PDDVCIVPEKFEGDIK--------QEGIGAFREGPPY-QRRGALQLWQFLVALLDDP-TNAHFIA 410
                .:|......|.:        ..||.....|... ||||:||||||||||||:| |:|..||
  Fly   459 ----NVVDSTTSSDAELRLDQFYASNGISTSSNGQAISQRRGSLQLWQFLVALLDEPTTSASCIA 519

Mouse   411 WTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEA 475
            ||||||||||||||||||.||:||||||||||||||||||||||||||||.||||||:|||:|:|
  Fly   520 WTGRGMEFKLIEPEEVARRWGLQKNRPAMNYDKLSRSLRYYYEKGIMQKVNGERYVYRFVCDPDA 584

Mouse   476 LFSLAF 481
            ||::|:
  Fly   585 LFNMAY 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Etv4	XP_006532521.1	ETS_PEA3_N	54..388	CDD:368026	74/395 (19%)
Etv4	XP_006532521.1	ETS	390..473	CDD:197710	74/83 (89%)
Ets96B	NP_996290.1	ETS	497..583	CDD:197710	74/85 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831912
Domainoid	1	1.000	149	1.000	Domainoid score	I4399
eggNOG	1	0.900	-	-		E1_KOG3806
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I4038
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001816
OrthoInspector	1	1.000	-	-		otm43926
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11849
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.850