DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frm-3 and Cdep

DIOPT Version :9

Sequence 1:	NP_001361874.1	Gene:	frm-3 / 186110	WormBaseID:	WBGene00001490	Length:	1091	Species:	Caenorhabditis elegans
Sequence 2:	NP_001097685.2	Gene:	Cdep / 40608	FlyBaseID:	FBgn0265082	Length:	4273	Species:	Drosophila melanogaster

Alignment Length:	1339	Identity:	370/1339 - (27%)
Similarity:	550/1339 - (41%)	Gaps:	384/1339 - (28%)

- Green bases have known domain annotations that are detailed below.

Worm     5 PRGV-GAPPPPGMNSSKRGRLVCIKVRMLDDTVAVFHLGHKAIGQTLLDEVCRHLNLLECDYFGL 68
            |.|| |.|..|   ..:.|:.:.::::||||::.:|.:..||:|:.|.::|||.|||||.|||||
  Fly    51 PSGVDGTPSTP---RHRGGKKLTVRIQMLDDSITMFQVQAKALGRVLFEQVCRQLNLLEADYFGL 112

Worm    69 SFIDINGNHC--WLDREKTILRQITNGSTDAKFYFVVKFYTPNPIDLEEEYTRYLFTMQIKRDLA 131
            .:.::: .|.  |||.||.:.||:.....|....|.:|||||:|..||||||||||.:|||||||
  Fly   113 EYQEVS-THTKYWLDLEKPMNRQVGLSLIDPVLRFCIKFYTPDPAQLEEEYTRYLFCLQIKRDLA 176

Worm   132 LGELHCSDNTASLLSAYLVQSECGDFSSEDYPDATYLSHTRFVPNQTLEFQKKVMDNHRNFIGMT 196
            .|.|.|:||||:|:::|:||:.||||..|||||.||||..||||||....|:|:|:||:..:|.:
  Fly   177 TGSLQCNDNTAALMASYIVQASCGDFVPEDYPDHTYLSSYRFVPNQDATMQRKIMENHKKHVGQS 241

Worm   197 PGESDLAMLEVARRCDFYGVKLHAAKDIDGNDAALSVMHLGIKVFRQLQLDTTFSWARIRKLSFK 261
            |.|:||.:||.||||:.||:|:|.|||::|....|:|.|:||.||:.:....|||||:|||:|||
  Fly   242 PAEADLNLLETARRCELYGMKMHPAKDVEGVPLNLAVAHMGITVFQNITRINTFSWAKIRKISFK 306

Worm   262 RKKLLVKLHPDSYQYLKETVEFSFETRDECKNFWKKCVEHHAFFRCVQAEE-PKKETRFFISKGS 325
            ||:.||||||:.|.|.|:||||.||.|:|||||||||||:|.||||...:. |:::|| .:|:||
  Fly   307 RKRFLVKLHPEGYGYYKDTVEFFFEGRNECKNFWKKCVENHGFFRCTAVQNTPRRKTR-VLSRGS 370

Worm   326 SFRYHGRTQKQLIDYVREHHKRREPFTR-------PLRSAASTRKGTY----------------- 366
            ||||.|:||||:|::|||::.:|:.|.|       ||.:::.::..||
  Fly   371 SFRYSGKTQKQIIEFVRENYVKRQNFQRSQSFRQGPLNASSRSQSHTYVNSSISANPLLPIDTAA 435

Worm   367 ---------SSTYGLV----------TDRPTKHRNGSV----YEPNQTDPYNKHQNT-------- 400
                     |.|..|.          .|.|..|....|    .|..||..|.....|
  Fly   436 WDYRNQCSDSMTPSLTKKAADTLDRRRDNPIGHMRSQVTAAQVEIYQTKNYAADSPTSQEEAECS 500

Worm   401 --------HSSM---------------PHIAHISSQPADHSFSGTLDARVGKSVTRDPSTSVTQH 442
                    ||::               |......|..:.|...|...|||...   |.:|.::.
  Fly   501 AAGAERQHHSAVAMDKLNSNRSLSPQGPQSWTSPSHSSHHQQRGPDPARVHPG---DHNTGLSH- 561

Worm   443 RLRQLKRSERCISDVDTVERPQRSS--------CRPVSHAINISSTSSKEQPDLSVSLPNVLSDD 499
                       :|.:.:...|:|.|        ..|...:||..|:|:......|.|.. |.|.|
  Fly   562 -----------LSHLYSSSTPRRVSVGSQAFVPASPQLISINTPSSSTNHNTMHSTSTV-VRSVD 614

Worm   500 LQMVCKEIEIEQNDPPKSVSGDNFQQRRSSRDYDNVSEDSYRLSDHERSTRSEVGVGSKFAAATI 564
            |.. ..|:|.|..||..:               |...|:...:.:.|.....|..|.|...|:||
  Fly   615 LNS-SMELEEEAEDPGTA---------------DTEEEEGEPVGEEEEEELVEEEVDSDLTASTI 663

Worm   565 FNSTFVA-----------------------RKPGSNVVKRVVAHTKST--------------PNS 592
            ...|..|                       |...|..:.....|..||              .||
  Fly   664 NRETMGAASAAAASASALGSGLASAHRPQLRSQESQSLTATPVHYSSTNYSMSKQCMLNNANANS 728

Worm   593 TDDEE-----------GALK--------------SASE----------YQTF----------RH- 611
            |:.|.           |..|              |.||          |.|.          :|
  Fly   729 TETETDNIIYTDINDMGHYKYPDFHSSAHQEHKISNSEHLNLNERNDIYATVNRKAKSKIREKHF 793

Worm   612 --------IKEYPFARNANI--VPIEIDGPNVDLSA----RRS--------------PAATTTT- 647
                    |.:|..|:...:  ||:.:..|:....|    .||              |:.::::
  Fly   794 SDEFIDQSILQYTRAKQMGLSQVPVLLQQPSTSAYAAALQERSYNSGSYQYHNDLNHPSESSSSS 858

Worm   648 -------TRTYANT-TTTVTTTSKVLTSSGAVLMKPKVISNDHEPSSGTHSSRVSPESGTYGALG 704
                   |:.|..: .|.:..:...||.           |.|.:.|..|||...:.|.....::.
  Fly   859 YFGTGFGTKRYGQSERTKLAQSENYLTP-----------SLDSQSSRHTHSLPRNSELSGVDSVD 912

Worm   705 PLPGRVITKENMMITPEGFKEKKAKPNPPPKPSF--PVQAVHSETEVVREIKTERASSHPLVHMQ 767
            ......||..::.|.|.|.....::     |..|  |...::|.|:.|   |.|.||:|.:
  Fly   913 SYDSHYITHHSVGILPPGHLSSSSE-----KLDFQLPSGNLYSTTQFV---KPEDASAHYM---- 965

Worm   768 EEIPFSRAPLKFEDKKERKSSLSRPALISVQSEDNPDVQKC-HLFNSDIPYTLTMRNVENTQSLP 831
                        ||::|.:..........|:.:.......| .||..   |:.|..:.|:  |.|
  Fly   966 ------------EDEEEEEEDEGENIYDQVERDSWLKSSSCKDLFER---YSSTYYDREH--SKP 1013

Worm   832 YSSFKDVSTAKKQGYESNSLKR-------------VSKSPEFKRRKSLDLVPRKRLPS---PGN- 879
            .::|      .|:...||.:..             |:|:......:....:|:.::.|   ||:
  Fly  1014 MTAF------DKEFLSSNRIDSPVTRYDDSRHSLYVAKNHSIDAHQGFSPLPQSKVYSSSYPGST 1072

Worm   880 FSAQDH--------TISPTTPDSDVLEYLLRRRSLLGDKSVIKTKSKRTDPRRQTQPVRFDLPPS 936
            ::.|:|        ..|.:..|.....|.|..:.   |......:.:..|..|.
  Fly  1073 YNTQEHKRQHGHHMDYSGSQDDISQDSYELLEKY---DIDFFGGRGRSEDHMRS----------- 1123

Worm   937 PCSPTAGGSTPFISILNDDLFDECVSESRSLHEDMDRLDKTTPHNQSISSFMSQKSRRDSEDSDV 1001
             ||..:|...|     :|   ||.|||....|:....:|   ..::|.:..|::  ..|:||...
  Fly  1124 -CSLDSGNYIP-----SD---DESVSEGHQQHKYRSEMD---VKSKSAADIMNE--IWDAEDPRY 1174

Worm  1002 MPPPPEEI---------LNKAMISSSRPAPPPPPPKSLAAAVKVAEMKAAAAG--------KIYY 1049
            :|.....:         :.:|::.:|          ||.:..::.|.|.:.:.        .:|:
  Fly  1175 LPREKLSVKSDGNFYKKIQEALVRTS----------SLESQSEMFETKISRSSDSSKKSRDSLYH 1229

Worm  1050 SGSSRTGKITDSPPFIDDSPKNSSASDAPSVPSPQKNCF 1088
            :.|.::.:.|.|        |.|.||...|..|...:||
  Fly  1230 TDSKKSRETTKS--------KTSVASSQDSKESLVGDCF 1260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frm-3	NP_001361874.1	B41	26..219	CDD:214604	104/194 (54%)
		FERM_C_FARP1-like	206..327	CDD:270014	71/121 (59%)
		FA	320..>353	CDD:370090	18/32 (56%)
Cdep	NP_001097685.2	B41	70..264	CDD:214604	104/194 (54%)
		FERM_N	73..134	CDD:286467	28/61 (46%)
		FERM_B-lobe	163..256	CDD:271216	56/92 (61%)
		FERM_C_FARP1-like	251..372	CDD:270014	71/121 (59%)
		FA	364..406	CDD:285894	20/42 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	154	1.000	Domainoid score	I2609
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto18951
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45858
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.040