Protein Alignment frm-3 and Cdep

DIOPT Version :10

• Sequence 1: NP_001427141.1
• Gene: frm-3 / 186110
• WormBaseID: WBGene00001490
• Length: 1091
• Species: Caenorhabditis elegans
• Sequence 2: NP_001097685.2
• Gene: Cdep / 40608
• FlyBaseID: FBgn0265082
• Length: 4273
• Species: Drosophila melanogaster
• Alignment Length: 1339
• Identity: 370/1339 - (27%)
• Similarity: 550/1339 - (41%)
• Gaps: 384/1339 - (28%)

 Worm     5 PRGV-GAPPPPGMNSSKRGRLVCIKVRMLDDTVAVFHLGHKAIGQTLLDEVCRHLNLLECDYFGL 68
            |.|| |.|..|   ..:.|:.:.::::||||::.:|.:..||:|:.|.::|||.|||||.|||||
  Fly    51 PSGVDGTPSTP---RHRGGKKLTVRIQMLDDSITMFQVQAKALGRVLFEQVCRQLNLLEADYFGL 112

 Worm    69 SFIDINGNHC--WLDREKTILRQITNGSTDAKFYFVVKFYTPNPIDLEEEYTRYLFTMQIKRDLA 131
            .:.::: .|.  |||.||.:.||:.....|....|.:|||||:|..||||||||||.:|||||||
  Fly   113 EYQEVS-THTKYWLDLEKPMNRQVGLSLIDPVLRFCIKFYTPDPAQLEEEYTRYLFCLQIKRDLA 176

 Worm   132 LGELHCSDNTASLLSAYLVQSECGDFSSEDYPDATYLSHTRFVPNQTLEFQKKVMDNHRNFIGMT 196
            .|.|.|:||||:|:::|:||:.||||..|||||.||||..||||||....|:|:|:||:..:|.:
  Fly   177 TGSLQCNDNTAALMASYIVQASCGDFVPEDYPDHTYLSSYRFVPNQDATMQRKIMENHKKHVGQS 241

 Worm   197 PGESDLAMLEVARRCDFYGVKLHAAKDIDGNDAALSVMHLGIKVFRQLQLDTTFSWARIRKLSFK 261
            |.|:||.:||.||||:.||:|:|.|||::|....|:|.|:||.||:.:....|||||:|||:|||
  Fly   242 PAEADLNLLETARRCELYGMKMHPAKDVEGVPLNLAVAHMGITVFQNITRINTFSWAKIRKISFK 306

 Worm   262 RKKLLVKLHPDSYQYLKETVEFSFETRDECKNFWKKCVEHHAFFRCVQAEE-PKKETRFFISKGS 325
            ||:.||||||:.|.|.|:||||.||.|:|||||||||||:|.||||...:. |:::|| .:|:||
  Fly   307 RKRFLVKLHPEGYGYYKDTVEFFFEGRNECKNFWKKCVENHGFFRCTAVQNTPRRKTR-VLSRGS 370

 Worm   326 SFRYHGRTQKQLIDYVREHHKRREPFTR-------PLRSAASTRKGTY----------------- 366
            ||||.|:||||:|::|||::.:|:.|.|       ||.:::.::..||
  Fly   371 SFRYSGKTQKQIIEFVRENYVKRQNFQRSQSFRQGPLNASSRSQSHTYVNSSISANPLLPIDTAA 435

 Worm   367 ---------SSTYGLV----------TDRPTKHRNGSV----YEPNQTDPYNKHQNT-------- 400
                     |.|..|.          .|.|..|....|    .|..||..|.....|
  Fly   436 WDYRNQCSDSMTPSLTKKAADTLDRRRDNPIGHMRSQVTAAQVEIYQTKNYAADSPTSQEEAECS 500

 Worm   401 --------HSSM---------------PHIAHISSQPADHSFSGTLDARVGKSVTRDPSTSVTQH 442
                    ||::               |......|..:.|...|...|||...   |.:|.::.
  Fly   501 AAGAERQHHSAVAMDKLNSNRSLSPQGPQSWTSPSHSSHHQQRGPDPARVHPG---DHNTGLSH- 561

 Worm   443 RLRQLKRSERCISDVDTVERPQRSS--------CRPVSHAINISSTSSKEQPDLSVSLPNVLSDD 499
                       :|.:.:...|:|.|        ..|...:||..|:|:......|.|.. |.|.|
  Fly   562 -----------LSHLYSSSTPRRVSVGSQAFVPASPQLISINTPSSSTNHNTMHSTSTV-VRSVD 614

 Worm   500 LQMVCKEIEIEQNDPPKSVSGDNFQQRRSSRDYDNVSEDSYRLSDHERSTRSEVGVGSKFAAATI 564
            |.. ..|:|.|..||..:               |...|:...:.:.|.....|..|.|...|:||
  Fly   615 LNS-SMELEEEAEDPGTA---------------DTEEEEGEPVGEEEEEELVEEEVDSDLTASTI 663

 Worm   565 FNSTFVA-----------------------RKPGSNVVKRVVAHTKST--------------PNS 592
            ...|..|                       |...|..:.....|..||              .||
  Fly   664 NRETMGAASAAAASASALGSGLASAHRPQLRSQESQSLTATPVHYSSTNYSMSKQCMLNNANANS 728

 Worm   593 TDDEE-----------GALK--------------SASE----------YQTF----------RH- 611
            |:.|.           |..|              |.||          |.|.          :|
  Fly   729 TETETDNIIYTDINDMGHYKYPDFHSSAHQEHKISNSEHLNLNERNDIYATVNRKAKSKIREKHF 793

 Worm   612 --------IKEYPFARNANI--VPIEIDGPNVDLSA----RRS--------------PAATTTT- 647
                    |.:|..|:...:  ||:.:..|:....|    .||              |:.::::
  Fly   794 SDEFIDQSILQYTRAKQMGLSQVPVLLQQPSTSAYAAALQERSYNSGSYQYHNDLNHPSESSSSS 858

 Worm   648 -------TRTYANT-TTTVTTTSKVLTSSGAVLMKPKVISNDHEPSSGTHSSRVSPESGTYGALG 704
                   |:.|..: .|.:..:...||.           |.|.:.|..|||...:.|.....::.
  Fly   859 YFGTGFGTKRYGQSERTKLAQSENYLTP-----------SLDSQSSRHTHSLPRNSELSGVDSVD 912

 Worm   705 PLPGRVITKENMMITPEGFKEKKAKPNPPPKPSF--PVQAVHSETEVVREIKTERASSHPLVHMQ 767
            ......||..::.|.|.|.....::     |..|  |...::|.|:.|   |.|.||:|.:
  Fly   913 SYDSHYITHHSVGILPPGHLSSSSE-----KLDFQLPSGNLYSTTQFV---KPEDASAHYM---- 965

 Worm   768 EEIPFSRAPLKFEDKKERKSSLSRPALISVQSEDNPDVQKC-HLFNSDIPYTLTMRNVENTQSLP 831
                        ||::|.:..........|:.:.......| .||..   |:.|..:.|:  |.|
  Fly   966 ------------EDEEEEEEDEGENIYDQVERDSWLKSSSCKDLFER---YSSTYYDREH--SKP 1013

 Worm   832 YSSFKDVSTAKKQGYESNSLKR-------------VSKSPEFKRRKSLDLVPRKRLPS---PGN- 879
            .::|      .|:...||.:..             |:|:......:....:|:.::.|   ||:
  Fly  1014 MTAF------DKEFLSSNRIDSPVTRYDDSRHSLYVAKNHSIDAHQGFSPLPQSKVYSSSYPGST 1072

 Worm   880 FSAQDH--------TISPTTPDSDVLEYLLRRRSLLGDKSVIKTKSKRTDPRRQTQPVRFDLPPS 936
            ::.|:|        ..|.:..|.....|.|..:.   |......:.:..|..|.
  Fly  1073 YNTQEHKRQHGHHMDYSGSQDDISQDSYELLEKY---DIDFFGGRGRSEDHMRS----------- 1123

 Worm   937 PCSPTAGGSTPFISILNDDLFDECVSESRSLHEDMDRLDKTTPHNQSISSFMSQKSRRDSEDSDV 1001
             ||..:|...|     :|   ||.|||....|:....:|   ..::|.:..|::  ..|:||...
  Fly  1124 -CSLDSGNYIP-----SD---DESVSEGHQQHKYRSEMD---VKSKSAADIMNE--IWDAEDPRY 1174

 Worm  1002 MPPPPEEI---------LNKAMISSSRPAPPPPPPKSLAAAVKVAEMKAAAAG--------KIYY 1049
            :|.....:         :.:|::.:|          ||.:..::.|.|.:.:.        .:|:
  Fly  1175 LPREKLSVKSDGNFYKKIQEALVRTS----------SLESQSEMFETKISRSSDSSKKSRDSLYH 1229

 Worm  1050 SGSSRTGKITDSPPFIDDSPKNSSASDAPSVPSPQKNCF 1088
            :.|.::.:.|.|        |.|.||...|..|...:||
  Fly  1230 TDSKKSRETTKS--------KTSVASSQDSKESLVGDCF 1260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frm-3	NP_001427141.1	None
Cdep	NP_001097685.2	B41	70..264	CDD:214604	104/194 (54%)
		FERM_C_FARP1-like	251..372	CDD:270014	71/121 (59%)
		FA	364..404	CDD:462582	20/40 (50%)
		GAPT	<1240..1299	CDD:463345	9/29 (31%)
		PTZ00121	<2219..2716	CDD:173412