Protein Alignment TOR1A and CG4880

DIOPT Version :9

• Sequence 1: NP_000104.1
• Gene: TOR1A / 1861
• HGNCID: 3098
• Length: 332
• Species: Homo sapiens
• Sequence 2: NP_573177.1
• Gene: CG4880 / 32680
• FlyBaseID: FBgn0030803
• Length: 351
• Species: Drosophila melanogaster
• Alignment Length: 333
• Identity: 61/333 - (18%)
• Similarity: 120/333 - (36%)
• Gaps: 84/333 - (25%)

Human     6 AVLGLLLLAPSVVQAVEPISLGLALAGVLTGY--IYPRLYCLFAECCGQKRSLSREALQKDLDDN 68
            |.:|:||      |..:.:|   .::|.|..|  .|..:.......|...|.|.        |..
  Fly    74 AGIGMLL------QFTDKLS---TVSGFLESYKNQYHSIVHNQDNYCNPSRRLG--------DMV 121

Human    69 LFGQH--LAKKIILNAVFGFINNPKPKKPLTLSLHGWTGTGKNFVSKIIAENI-YEGGLNSDYVH 130
            |..:|  |.:.:.||.:...::|...:   .:.|.|.:|.||:..::|:.|.. :...:|
  Fly   122 LHARHQVLNQDLALNQLELALDNTTNE---AIVLVGTSGVGKSHTARILRETFPWPENVN----- 178

Human   131 LFVATLHFPHASNITLYKDQLQLWIRGNVSACARSIFIFDEMDKMHAGLIDAIKPFLDYYDL--- 192
                ||.:..:|::...|..|     ..::.|.:::.:.|.|....|..:..|...:...:.
  Fly   179 ----TLSWTGSSSLGRVKSML-----SGLTYCGQNMILIDNMTPKDAHFVPIINEMISEGEKSAN 234

Human   193 -VDGVSYQKAMFIFLSNAGAERITDVALDFWRSGKQREDIKLKDIEHALSVSVFNNKNSGFWHSS 256
             .:....::...:|:.|..:          .:.|::.|          :.:.:..|..    |:.
  Fly   235 HTEHPQQKRLTIVFIFNVNS----------MQPGEEFE----------MDMEILRNMP----HTQ 275

Human   257 LIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEIDEDIVSRVAEEMTFFPKEERVFSDKGCKT 321
            |         |.|..|:..||..|||.|.......::::.|..:.:.:.        .|..|||:
  Fly   276 L---------VTFATLDPTHLVDCIRREAAIAMVHLEDEHVEEIIKSID--------ASASGCKS 323

Human   322 VFTKLDYY 329
            :..|:..|
  Fly   324 ILAKVLLY 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TOR1A	NP_000104.1	Torsin	44..169	CDD:148114	24/127 (19%)
		Interaction with SNAPIN	91..251		23/164 (14%)
		Interaction with KLC1. /evidence=ECO:0000269|PubMed:14970196	251..332		18/79 (23%)
		Interaction with SYNE3. /evidence=ECO:0000269|PubMed:18827015	312..332		6/18 (33%)
CG4880	NP_573177.1	AAA	131..>181	CDD:99707	12/61 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10760
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100