DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdx1 and zen2

DIOPT Version :9

Sequence 1:	NP_032840.1	Gene:	Pdx1 / 18609	MGIID:	102851	Length:	284	Species:	Mus musculus
Sequence 2:	NP_476794.1	Gene:	zen2 / 40827	FlyBaseID:	FBgn0004054	Length:	252	Species:	Drosophila melanogaster

Alignment Length:	169	Identity:	59/169 - (34%)
Similarity:	83/169 - (49%)	Gaps:	42/169 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse   139 AYTAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWK 203
            |.|...|::||:|||::..||:|||:||..|||::|.||:|::..|.||||.:||||||||||.|
  Fly    35 ATTRSSEKSKRSRTAFSSLQLIELEREFHLNKYLARTRRIEISQRLALTERQVKIWFQNRRMKLK 99

Mouse   204 KEEDKKRSSGT-----PSGGGGGEEPEQDCAVTSGEELL-------AVPPLPPPGGAVPPGVPAA 256
            |..::|.:.|.     |......|:.::|..:.  |.||       ...||            ..
  Fly   100 KSTNRKGAIGALTTSIPLSSQSSEDLQKDDQIV--ERLLRYANTNVETAPL------------RQ 150

Mouse   257 VREGLLPSGL------------SVSPQPSSIAPLRPQEP 283
            |..|:|..|.            ..||:|.::    ||.|
  Fly   151 VDHGVLEEGQITPPYQSYDYLHEFSPEPMAL----PQLP 185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdx1	NP_032840.1	Transactivation domain. /evidence=ECO:0000250	13..73
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..116
		Antp-type hexapeptide	119..124
		Homeobox	150..203	CDD:278475	32/52 (62%)
		Nuclear localization signal	198..204		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..284		22/106 (21%)
zen2	NP_476794.1	Homeobox	46..99	CDD:278475	32/52 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810