DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment F49C5.4 and par-1

DIOPT Version :9

Sequence 1:	NP_496679.3	Gene:	F49C5.4 / 186015	WormBaseID:	WBGene00009867	Length:	503	Species:	Caenorhabditis elegans
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	164/531 - (30%)
Similarity:	267/531 - (50%)	Gaps:	89/531 - (16%)

- Green bases have known domain annotations that are detailed below.

Worm     1 MQP---STSSPSSSSMGSRMRDSGGLARR----TVRSDPPTYSSILEYNVEEEVSEAESEESYEK 58
            |.|   |::|.:|:|..:....:.|.|..    :|...|.|.|:          |.|.:..|::.
  Fly   103 MMPIVTSSNSATSNSTAATPTPASGAAATGGVGSVSQGPATVSA----------SAANTNHSHQH 157

Worm    59 PPEHVPARFVPTQRSDDGGYPA-------------HHHHEAFNRTVSAVSLPVGKQLKDMSEKTQ 110
            ..:|  ...|....:.||...:             ||||   :...|.|:..|.|.:  :|..:.
  Fly   158 SHQH--HHHVANNMTTDGARLSSNNSAVVASSAINHHHH---HTPGSGVAPTVNKNV--LSTHSA 215

Worm   111 YERAILQLNND-------------PVVHKEVALGRRIGFYRLGKELGAGNFSKVKLGVHQLTKEK 162
            :..||.|..:.             |:..:  |....||.|:|.|.:|.|||:||||..|..|.::
  Fly   216 HPSAIKQRTSSAKGSPNMQMRSSAPMRWR--ATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKE 278

Worm   163 VAVKIMDKAKMDAKAQKLLSREIQAMEEMNHPNIVKLFEVVETLTRVHLVIEYASGGELYTYVHE 227
            ||:||:||.:::..:.:.|.||::.|:.::||||||||:|:||...::|::|||||||::.|:..
  Fly   279 VAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVL 343

Worm   228 RGKLTEGDAKPLFAQIVSAVSHMHSRNIVHRDIKAENVMFSSPNTVKLVDFGFSCLVDREQMLRT 292
            .|::.|.:|:..|.||||||.:.|.:.|:|||:||||::..|...:|:.|||||........|.|
  Fly   344 HGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDT 408

Worm   293 FCGSPPYAAPELFQDTSYAGELVDVWALGVLLFFMLIGVTPFKAETVPDMKVLITAGKYQIPDYV 357
            ||||||||||||||...|.|..||||:|||:|:.::.|..||...|:.:::..:..|||:||.|:
  Fly   409 FCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYM 473

Worm   358 SLLATELIKSMLKTDTGQRADIDSVKKHFWMRDCRFTKSYLSIKATAKIDNEEEKKAIDDKVWKI 422
            |.....|::..|..:..:||.::::....|| :..|.:..|......|.|..:.|:
  Fly   474 STDCENLLRKFLVLNPAKRASLETIMGDKWM-NMGFEEDELKPYIEPKADLADPKR--------- 528

Worm   423 LNNYGIVKEMI--------VEENLDKGPRDAVVGTYRIVQFQVQSEITRLAKEKDEPQPSSSSFT 479
                  ::.::        :|.:|.:...|.|..||.:           |.::..:|:...|  .
  Fly   529 ------IEALVAMGYNRSEIEASLSQVRYDDVFATYLL-----------LGRKSTDPESDGS--R 574

Worm   480 NGSPTSVKDVN 490
            :||..|:::::
  Fly   575 SGSSLSLRNIS 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
F49C5.4	NP_496679.3	STKc_NIM1	134..388	CDD:270977	112/253 (44%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	110/251 (44%)
		S_TKc	253..504	CDD:214567	110/250 (44%)
		UBA_MARK_Par1	525..563	CDD:270522	8/63 (13%)
		MARK1-3_C	839..936	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910