DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdha1 and CG7024

DIOPT Version :9

Sequence 1:	NP_032836.1	Gene:	Pdha1 / 18597	MGIID:	97532	Length:	390	Species:	Mus musculus
Sequence 2:	NP_572182.1	Gene:	CG7024 / 31407	FlyBaseID:	FBgn0029722	Length:	479	Species:	Drosophila melanogaster

Alignment Length:	354	Identity:	186/354 - (52%)
Similarity:	240/354 - (67%)	Gaps:	7/354 - (1%)

- Green bases have known domain annotations that are detailed below.

Mouse    40 KCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGL 104
            ||  :.||.||.:...|:|||.|..|..|..:||.|..|...||::.|||||||.:||||..||:
  Fly    44 KC--YDLENGPTMDVELSREDALTMYTQMLELRRFETVAGNYYKERKIRGFCHLYNGQEAVAVGM 106

Mouse   105 EAGINPTDHLITAYRAHGFTFTRGLPVRAILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGA 169
            :..:...|.:|||||.|.:|:..|:.:..|:|||.|.|.||::|||||||||:..||||||||||
  Fly   107 KQRLRSCDSVITAYRCHAWTYLMGVSLYEIMAELFGVRTGCSRGKGGSMHMYSDKFYGGNGIVGA 171

Mouse   170 QVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVE 234
            ||||||||.||..|...:.|.:.||||||||||||||::|||.||.|||||:||||.|||||.|:
  Fly   172 QVPLGAGIGLAHSYRKDNGVSVVLYGDGAANQGQIFESFNMAKLWCLPCIFVCENNHYGMGTHVK 236

Mouse   235 RAAASTDYYKRGDFIPGLRVDGMDILCVREATKFAAAYCRSGKGPILMELQTYRYHGHSMSDPGV 299
            ||:|.|::|.||.:||||.|||..:|.||.||:||..:... .|||::|:.||||.||||||||.
  Fly   237 RASAMTEFYMRGQYIPGLWVDGNQVLAVRSATQFAVDHALK-HGPIVLEMSTYRYVGHSMSDPGT 300

Mouse   300 SYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEEL 364
            |||:|||:|..|.|.|||...:.:::...||..||||.:|.:.||:::...:.||.|.|..|:||
  Fly   301 SYRSREEVQSTREKRDPITSFRSQIIALCLADEEELKALDDKTRKQVDSICKKATTDREVELDEL 365

Mouse   365 GYHIYSSDPPFEVRGAN----QWIKFKSV 389
            ...||:.:...::||.:    :.||...|
  Fly   366 HTDIYAKNVDGKIRGVSGFHLEHIKLAEV 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdha1	NP_032836.1	PDH_E1_alph_y	58..370	CDD:274473	173/311 (56%)
CG7024	NP_572182.1	TPP_enzymes	37..381	CDD:294952	182/339 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834074
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S510
OMA	1	1.010	-	-		QHG54057
OrthoDB	1	1.010	-	-		D318981at33208
OrthoFinder	1	1.000	-	-		FOG0001471
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100754
Panther	1	1.100	-	-	LDO	PTHR11516
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X926
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.670