DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdgfrb and htl

DIOPT Version :9

Sequence 1:	NP_001139740.1	Gene:	Pdgfrb / 18596	MGIID:	97531	Length:	1099	Species:	Mus musculus
Sequence 2:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	839	Identity:	216/839 - (25%)
Similarity:	337/839 - (40%)	Gaps:	280/839 - (33%)

- Green bases have known domain annotations that are detailed below.

Mouse   227 GESITIRCIVMGNDVVNFQW----------TYPRMKSGRLVEPVTDYLFGVPSRIGSILHIPTAE 281
            |..:|:.|..:||...|..|          .|..:|..|....:.|.:.|
  Fly   118 GSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPG--------------- 167

Mouse   282 LSDSGTYTCNV-----------SVSVNDHGDEKAI------NISVIENG----YVRLLETLGDVE 325
              |.|.|||.|           .|.|:|..:.|.|      |::::.|.    :.:.|..|
  Fly   168 --DCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDL---- 226

Mouse   326 IAELHRSRTLRVVFEAYPMPSVLWLKDNRTLGDSGAGELVLSTRNMSETRYVSELILVRVKVSEA 390
                    |.:..:...|...:....:||::              ::|.:  .:|..|.|::.:.
  Fly   227 --------TSKKAWIFVPCHGMTNCSNNRSI--------------IAEDK--DQLDFVNVRMEQE 267

Mouse   391 GYYTMRAFHEDDEVQLSFKLQVNVPVRVLELSESHPANGEQTIRCRGRGMPQPNVTWSTCRDLKS 455
            |:||....:...:...:..|:|   ||.|.:.|:..|:|
  Fly   268 GWYTCVESNSLGQSNSTAYLRV---VRSLHVLEAGVASG-------------------------- 303

Mouse   456 RCPRKLSPTPLGNSSKEESQ--------------LETNVTFWE-EDQEYEVVSTLRLRHVDQPLS 505
                          |...:.              :.|...|:. ...::|.|...|:..|.|...
  Fly   304 --------------SLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTK 354

Mouse   506 VRCMLQNSMGGDSQEVTVVPHSLPFKVVVISAILALVVLTVISLIILIMLWQKKPRYEIRWKVIE 570
            ...:.:...||||                 |..:..:::.|:.:        :|.|        .
  Fly   355 KVIIFKPEGGGDS-----------------SGSMDTMIMPVVRI--------QKQR--------T 386

Mouse   571 SVSSDGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKM 635
            :|..:|:|....:..:.|.||.|||||..||||.|||.||||:||.|..:...       |||||
  Fly   387 TVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI-------VAVKM 444

Mouse   636 LKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTF 700
            :|......:..:|:.|:::|..:|.|:|::||||.|::.||:|:|.||..:|:|.|:|::|:
  Fly   445 VKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNR--- 506

Mouse   701 LQRHSNKHCPPSAELYSNALPVGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYAD 765
                                |.|                 .|..:|.|
  Fly   507 --------------------PFG-----------------RDQDRDSS----------------- 517

Mouse   766 IESPSYMAPYDNYVPSAPERTYRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAAR 830
             :.|          ||.|           :.|::..||:.|::|:|.|||:|||:.|:|||||||
  Fly   518 -QPP----------PSPP-----------AHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAAR 560

Mouse   831 NVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWE 895
            |||:.:..::||.||||||||.....|....:..||:|||||||:....|.:.|||||:||||||
  Fly   561 NVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWE 625

Mouse   896 IFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLER 960
            |.|.|..|||.:...::.|..:..|.||.:||..|..||.:|::||....:.||||:::|..:::
  Fly   626 IMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDK 690

Mouse   961 LLGEGYKKKYQQVDEEFLRSDHPAILRSQARFPGIHSLRSPLDTSSVLYTAVQPNESDN 1019
            ||         |..|::|..|             |.:|.:|..||.     .:.:|:||
  Fly   691 LL---------QTKEDYLDVD-------------IANLDTPPSTSD-----EEEDETDN 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdgfrb	NP_001139740.1	ig	36..113	CDD:278476
		IG_like	221..309	CDD:214653	24/108 (22%)
		Ig	227..311	CDD:299845	24/110 (22%)
		Ig	313..414	CDD:299845	15/104 (14%)
		IG	334..412	CDD:214652	12/77 (16%)
		PKc_like	562..953	CDD:304357	139/390 (36%)
		Pkinase_Tyr	600..953	CDD:285015	128/352 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1017..1099		2/3 (67%)
htl	NP_524394.2	Ig	112..191	CDD:299845	19/89 (21%)
		IG_like	113..191	CDD:214653	19/89 (21%)
		IG_like	205..289	CDD:214653	16/111 (14%)
		PKc_like	404..692	CDD:304357	137/373 (37%)
		STYKc	416..688	CDD:214568	129/357 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810