Protein Alignment Pdgfra and tor

DIOPT Version :9

• Sequence 1: NP_001076785.1
• Gene: Pdgfra / 18595
• MGIID: 97530
• Length: 1089
• Species: Mus musculus
• Sequence 2: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Alignment Length: 1159
• Identity: 249/1159 - (21%)
• Similarity: 398/1159 - (34%)
• Gaps: 432/1159 - (37%)

Mouse    12 SCLL------TGPGLISCQLLLPSILPNENEKIVQLNSSFSLRCVGESE----VSW-QHPMSEED 65
            |||.      |.||.:               :.||.|...::.|..|||    :.| ||....|.
  Fly    55 SCLKDCRINGTFPGAL---------------RKVQENYQMNMICRTESEIVFQIDWVQHSRGTEP 104

Mouse    66 DPNV-------EIRSEENNSGLFVT-----VLEVVNASAAHT---------GWYTCYYNHTQTDE 109
            .||.       .::.:...:.|:::     :|..:.:::.|.         |.|:.... .||..
  Fly   105 APNATYIIRVDAVKDDNKETALYLSDDNFLILPGLESNSTHNITALAMHGDGSYSLIAK-DQTFA 168

Mouse   110 SEIEGR--------HIYIYVPDPDMAFVPLGMTDSLVIVEEDDSAIIPCR-----------TTDP 155
            :.|.|.        ::..:||.||      .:......:|...||...|.           ..|.
  Fly   169 TLIRGYQPSKMGAVNLLRFVPQPD------DLHHIAAEIEWKPSAESNCYFDMVSYSTNSVNMDE 227

Mouse   156 ETQVTLHNNGRLVPASYDSRQGFNGTFSVGPYICEATVKGRTFKTSEFNVYALKATSELNLEMDA 220
            ..:|...:..:|...:.|                                         |||.|.
  Fly   228 PLEVQFRDRKKLYRHTVD-----------------------------------------NLEFDK 251

Mouse   221 RQTVYKAGETIVVTCAVFNNEVVDLQWTYPGEVRNKGITMLEEIKLPS----IKLVYTLTVPKAT 281
            :   |..|   |.|..:.|....||||.              .|.:||    ....|||..|.
  Fly   252 Q---YHVG---VRTVNIMNRLESDLQWL--------------PIAVPSCLDWYPYNYTLCPPH-- 294

Mouse   282 VKDSGEYECAARQATKEVKEMKRVTISVHEKGFVEIEPTFGQLEAVNLHEVREFVVEVQAYPTPR 346
                                 |...::|.:|.::.      .:.|:|:           .:..||
  Fly   295 ---------------------KPENLTVTQKQYLP------NILALNI-----------TWARPR 321

Mouse   347 ISWLKDNLT-----LIENLTEITTDVQKSQETRYQSKLKLIRAKEEDSGHYTI--IVQNEDDVKS 404
              :|.||.|     |.:..||:...:.:::...|..|:.::      ..|:.:  :.|
  Fly   322 --YLPDNYTLHIFDLFKGGTELNYTLDQNRSHFYVPKITVL------GSHFEVHLVAQ------- 371

Mouse   405 YTFELSTLVPASILDLVDDHHGSGGGQTVRCTAEGTPLPEIDWMICKHIKKCNNDTSWTVLASNV 469
                                  |.||:                                    ||
  Fly   372 ----------------------SAGGK------------------------------------NV 378

Mouse   470 SNIITELPRRGRSTVEGRVSFAKVEETIAVRCLAKNNLSVVARELKLVAPTLRSELTVAAAVLVL 534
            |.:..:...||                                       .|.||..:...||.:
  Fly   379 SGLTLDKVHRG---------------------------------------VLLSEGNMVKLVLFI 404

Mouse   535 LVIVIVSLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPM-------------QLPYDSRW 586
            :|.:...|::..:.:.::.|.|::...:::......|: ::..|             .|......
  Fly   405 IVPICCILMLCSLTFCRRNRSEVQALQMDAKDAKASEF-HLSLMDSSGLLVTLSANESLEVMDEL 468

Mouse   587 EFPRDGLVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHL 651
            |.....::|..:||.||||.|..|.       ....:||||:||......:..|...|::::..:
  Fly   469 EVEPHSVLLQDVLGEGAFGLVRRGV-------YKKRQVAVKLLKDEPNDEDVYAFKCEIQMLKAV 526

Mouse   652 GPHLNIVNLLGACTK-SGPIYIITEYCFYGDLVNYLHK--------------------------N 689
            |.|.|||.::|..|: |..:.::.|||..|.|.|:|.:                          |
  Fly   527 GKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFN 591

Mouse   690 R--------------DSFMSQHPEKPKKD------LDIFGL----NPADESTRSYVILSFENNGD 730
            |              :|.:|...|:.:.|      .:.:.|    |.||  .:.|.:...||.|.
  Fly   592 RLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITNAAD--NKGYGLEDIENIGG 654

Mouse   731 YMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDDSE---GLTL 792
            ....|.|:..:..|..:.|...|    :.|..|..:..||:...:.|..:.|...|::   .|..
  Fly   655 SYIPKTAEAPKDRPKRKLKPQPK----KDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKY 715

Mouse   793 LDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNY-VSKGSTF 856
            .|||....|||.||||||....|||||||||||::..:.:||.||||:||:.|::.| .|.||..
  Fly   716 ADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGK 780

Mouse   857 LPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHA 921
            ||:||:|.||:...:||:.|||||:|:||:||.:|||.|||.:. .|.....::.|:||.:|:..
  Fly   781 LPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVS-PSDLLQLLRQGHRMKRPEGC 844

Mouse   922 TSEVYEIMVQCWNSEPEKRPSFYHLSE------IVENLLPGQYKKSYEKIHLDFLKSDHPAVARM 980
            |.|::.:|..||:|.|..||:|..|..      :..|.:|.:.|:
  Fly   845 TQEMFSLMESCWSSVPSHRPTFSALKHRLGGMILATNDVPERLKQ-------------------- 889

Mouse   981 RVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDL 1034
                       .....|.|||..: ||:.:              ::.||.||:|
  Fly   890 -----------LQAATESKLKSCD-GLNSK--------------VEQVPCEEEL 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdgfra	NP_001076785.1	Ig_3	28..100	CDD:372822	18/97 (19%)
		Ig_PDGFR-alphabeta	228..311	CDD:143269	17/86 (20%)
		Ig4_PDGFR	313..413	CDD:143267	15/106 (14%)
		Ig_TrkABC_d4	416..497	CDD:143173	8/80 (10%)
		PTKc_PDGFR_alpha	555..956	CDD:173653	142/474 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1018..1089		5/17 (29%)
tor	NP_476762.1	FN3	199..261	CDD:214495	16/108 (15%)
		STYKc	475..873	CDD:214568	136/411 (33%)
		PTKc	479..873	CDD:270623	135/407 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010