DRSC/TRiP Functional Genomics Resources

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Protein Alignment DYRK1A and YAK1

DIOPT Version :10

Sequence 1:NP_001387.2 Gene:DYRK1A / 1859 HGNCID:3091 Length:763 Species:Homo sapiens
Sequence 2:NP_012394.1 Gene:YAK1 / 853300 SGDID:S000003677 Length:807 Species:Saccharomyces cerevisiae


Alignment Length:688 Identity:194/688 - (28%)
Similarity:319/688 - (46%) Gaps:133/688 - (19%)


- Green bases have known domain annotations that are detailed below.


Human     2 HTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQ-------VSALSYS 59
            :|...||....||.:....:......:...|.: |..|:..|..|::.|:|       ::|.:||
Yeast   150 YTSSNTSLAGNSSGQYPSGYQQQQQQVYQQGAI-HPSQFGSRFVPSLYDRQDFQRRQSLAATNYS 213

Human    60 DQIQ---------------------------------QPLTNQVMPDIVMLQR-RMPQ------- 83
            ....                                 ||...|:..|.|..|: .:||       
Yeast   214 SNFSSLNSNTNQGTNSIPVMSPYRRLSAYPPSTSPPLQPPFKQLRRDEVQGQKLSIPQMQLCNSK 278

Human    84 ----------------TFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKE 132
                            :......:||..::..||.||...:..:..:..:..::.....|..|  
Yeast   279 NDLQPVLNATPKFRRASLNSKTISPLVSVTKSLITTYSLCSPEFTYQTSKNPKRVLTKPSEGK-- 341

Human   133 RKVYNDGYDDDNYDYIV----KNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNK 193
               .|:|:|:.|.|||:    ..|.:...:|.:..::|:|:||||||..:.:.:|.:|:|::|::
Yeast   342 ---CNNGFDNINSDYILYVNDVLGVEQNRKYLVLDILGQGTFGQVVKCQNLLTKEILAVKVVKSR 403

Human   194 KAFLNQAQIEVRLLELMN-KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGV 257
            ..:|.|:..|.::|||:| |.|...|::.:.:...|:.:||||||||:||.|||:||:...|.|:
Yeast   404 TEYLTQSITEAKILELLNQKIDPTNKHHFLRMYDSFVHKNHLCLVFELLSNNLYELLKQNKFHGL 468

Human   258 SLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYI 322
            |:.|.|.|..|:..:|..|  .|..:|||||||||||||.|.:..:||:||||||:..:.:|.||
Yeast   469 SIQLIRTFTTQILDSLCVL--KESKLIHCDLKPENILLCAPDKPELKIIDFGSSCEEARTVYTYI 531

Human   323 QSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQ 387
            ||||||:||::||:||..:|||||||||:.|:..|.|:|.||:|.:|:.:|::.||.||:.::|.
Yeast   532 QSRFYRAPEIILGIPYSTSIDMWSLGCIVAELFLGIPIFPGASEYNQLTRIIDTLGYPPSWMIDM 596

Human   388 APKARKFFEKL-PDGT------WNLKKTKDGKREY----KPPGT----RKLHNIL-------GVE 430
            ...:.||.:|| |:.:      ..:|..::..|||    ||...    |||.:|:       .::
Yeast   597 GKNSGKFMKKLAPEESSSSTQKHRMKTIEEFCREYNIVEKPSKQYFKWRKLPDIIRNYRYPKSIQ 661

Human   431 TGGPGGRRAGESGHTVADYLKFKDLILR----MLDYDPKTRIQPYYALQHSFFKKTADEGT-NTS 490
                      .|...:...::.::.::.    :|:.:|..|..|..|:.|.|..|....|. ...
Yeast   662 ----------NSQELIDQEMQNRECLIHFLGGVLNLNPLERWTPQQAMLHPFITKQEFTGEWFPP 716

Human   491 NSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDC---- 551
            .|....|:.:...:.|..|...|::..|   :|:|       |.:.::....|....::|.    
Yeast   717 GSSLPGPSEKHDDAKGQQSEYGSANDSS---NNAG-------HNYVYNPSSATGGADSVDIGAIS 771

Human   552 ---ETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQE 586
               |..|..:...|  .:..|..|.||....:.|.|:|
Yeast   772 KRKENTSGDISNNF--AVTHSVQEGPTSAFNKLHIVEE 807

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DYRK1ANP_001387.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 32..57 8/31 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 115..136 2/20 (10%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 117..134 2/16 (13%)
PKc_DYRK1 148..484 CDD:271128 135/366 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..442 9/48 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 485..540 10/55 (18%)
Histidine-rich domain (HRD). /evidence=ECO:0000269|PubMed:29849146 595..625
Disordered. /evidence=ECO:0000269|PubMed:29849146 596..679
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 744..763
YAK1NP_012394.1 PKc_YAK1 369..704 CDD:271114 131/346 (38%)
Blue background indicates that the domain is not in the aligned region.

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