Protein Alignment DYRK1A and dyrk1a

DIOPT Version :10

• Sequence 1: NP_001387.2
• Gene: DYRK1A / 1859
• HGNCID: 3091
• Length: 763
• Species: Homo sapiens
• Sequence 2: XP_012812685.1
• Gene: dyrk1a / 779733
• XenbaseID: XB-GENE-1017105
• Length: 771
• Species: Xenopus tropicalis
• Alignment Length: 761
• Identity: 701/761 - (92%)
• Similarity: 719/761 - (94%)
• Gaps: 14/761 - (1%)

Human     4 GGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSH-QYSDRRQPNISDQQVSALSYSDQIQQPLT 67
            |||||||||||||||||||||||||||||||.||| |||||||.|::|||.|||.|:|||||||.
 Frog    24 GGETSACKPSSVRLAPSFSFHAAGLQMAGQMSHSHQQYSDRRQQNLNDQQASALPYNDQIQQPLP 88

Human    68 NQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKE 132
            |         |||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog    89 N---------QRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKE 144

Human   133 RKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFL 197
            |||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||
 Frog   145 RKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRAEQEWVAIKIIKNKKAFL 209

Human   198 NQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLT 262
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   210 NQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLT 274

Human   263 RKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFY 327
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   275 RKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFY 339

Human   328 RSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKAR 392
            |||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||
 Frog   340 RSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMSKIVEVLGIPPAHILDQAPKAR 404

Human   393 KFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLIL 457
            |||||:|:||||||||||||:||||||||||||:||||||||||||.||||||||||||||||||
 Frog   405 KFFEKMPEGTWNLKKTKDGKKEYKPPGTRKLHNLLGVETGGPGGRRGGESGHTVADYLKFKDLIL 469

Human   458 RMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTS 522
            ||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   470 RMLDYDAKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTS 534

Human   523 NSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQET 587
            |||||||||||||||||||||||||||||||||||||||||.  ||:..|||||||:||||||||
 Frog   535 NSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPP--GWTVPEAPTQVTIETHPVQET 597

Human   588 TFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSH 652
            ||||.|.|..:.|||||.|  |||||||||||||..|.||||.|:||||:.||||||||:|||||
 Frog   598 TFHVPPSQQNVPHHHGNGS--HHHHHHHHHHHGQHVLSNRTRTRIYNSPSTSSSTQDSMDVGHSH 660

Human   653 HSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGH 717
            ||||||||||||||||||||||||||||||||||||||||||||.||||||.:|||||||||.||
 Frog   661 HSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGTMDVNLTAFSNPRQETGITGH 725

Human   718 PTYQFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS 763
            |.||:||||||.||:||||||||||.|||:||||||||||||||||
 Frog   726 PDYQYSANTGPGHYVTEGHLTMRQGMDREDSPMTGVCVQQSPVASS 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DYRK1A	NP_001387.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	32..57		19/25 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..136		20/20 (100%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		16/16 (100%)
		PKc_DYRK1	148..484	CDD:271128	327/335 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..442		30/33 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..540		54/54 (100%)
		Histidine-rich domain (HRD). /evidence=ECO:0000269|PubMed:29849146	595..625		20/29 (69%)
		Disordered. /evidence=ECO:0000269|PubMed:29849146	596..679		67/82 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	744..763		17/18 (94%)
dyrk1a	XP_012812685.1	PKc_DYRK1	160..496	CDD:271128	327/335 (98%)