DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DYRK1A and Hipk

DIOPT Version :9

Sequence 1:	NP_001387.2	Gene:	DYRK1A / 1859	HGNCID:	3091	Length:	763	Species:	Homo sapiens
Sequence 2:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster

Alignment Length:	923	Identity:	253/923 - (27%)
Similarity:	362/923 - (39%)	Gaps:	263/923 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    50 DQQVSALS----YSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEV 110
            ||.|:|.:    :.:|.||.|..|....|:          |.|||:.... ||....|
  Fly    43 DQTVTATTDGTRHQEQQQQQLQQQQQQHIL----------RQPATSASTS-SVAAAAT------- 89

Human   111 YYAKKKRR--------------H----QQ-----------------GQGDD---------SSHKK 131
              :|:||:              |    ||                 |.|.|         ::|.|
  Fly    90 --SKRKRQTDCDCGCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTK 152

Human   132 ------------ERKVYNDGYDDDNYDYIVKNGE---KWMDRYEIDSLIGKGSFGQVVKAYDRVE 181
                        ..|..:.|.|.   ||.:...|   .....||:...:|:|:||||||.:.|..
  Fly   153 VATSGGHANTQPPSKRSSSGADG---DYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGT 214

Human   182 QEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLY 246
            .|.|||||:||..::..|.||||.:|..:::.:.: ::..|.....|..:||.|||||||..|||
  Fly   215 SEIVAIKILKNHPSYARQGQIEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLY 278

Human   247 DLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRS--AIKIVDFG 309
            |.|:...|..:.|...|...:|:.||||.|  .:|.:||.|||||||:|.:|.|.  .:|::|||
  Fly   279 DFLKQNKFSPLPLKYIRPILEQVLTALLKL--KQLGLIHADLKPENIMLVDPVRQPYRVKVIDFG 341

Human   310 SSCQLGQRIYQ-YIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKI 373
            |:..:.:.:.. |:|||:||:||::||:|:..|||||||||::.|:..|.||:.|::|.||:..|
  Fly   342 SASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYI 406

Human   374 VEVLGIPPAHILDQAPKARKFFEKLPDGT---WNLKKTKDGKRE--YKPPGTRK-LHNIL----- 427
            .:..|:|..|:|:.|.|..|||.:..|.|   |.||.|::.:.|  .|....|| :.|.|
  Fly   407 SQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQ 471

Human   428 -GVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSN 491
             .|.|...||:...|.    .|..:|.||:.|||..|.:.|:.|..||.|||.:.|........|
  Fly   472 VNVPTDLEGGQLLAEK----TDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCN 532

Human   492 SVSTSPAM-----------EQSQSSGTTSSTSSSSGGSSGTSN---------------------- 523
            :|..|..|           .|..|:..|:...||:...:.|.|
  Fly   533 NVKASVQMMEVCRRGDFHTVQPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGL 597

Human   524 ----SGR--ARSDP---THQHRHSGGHFTAAVQAMDCETHSPQVRQQFPAP-----LGWSGTEAP 574
                :||  ||..|   |...:|.      .|..:.|    |...|..|:|     :|.:..:.|
  Fly   598 YQIYNGRSVARQYPQTRTDSFQHQ------LVSNILC----PPSYQTMPSPTKHVVVGSATMQPP 652

Human   575 TQVTVE----------------------THPVQ-------ETTFHVA-----PQQNALH------ 599
            .||..:                      |:.||       :|...:|     |||...|
  Fly   653 LQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDS 717

Human   600 -----------HHHGN--------SSHHHH---------HHHHHHHHHGQQALGNRTRPRVYNSP 636
                       .||.|        .|..||         ..|....|.....:..|.:.   :||
  Fly   718 TPLFNVEEIYPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKE---SSP 779

Human   637 TNSSSTQDSMEVG---HSHHS---------MTSLSSSTTSSSTSSSS--TGNQGNQAYQNRPVAA 687
            .:....|.:..|.   |:||:         ..|..|...||:.|||:  .|:..:..:.:.|||
  Fly   780 PHQQRYQRAAHVSPQYHAHHNCNYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHVPVA- 843

Human   688 NTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAH----YMTEGHLTMRQGADREES 748
                ..|..:......:.||.....|..|...||    ..|||    :..:.|....|.....:.
  Fly   844 ----HAQPYSSSSGHHIVSNCNANGGAGGAVVYQ----QPPAHAHQQHGQQPHPQSSQHPQHVKQ 900

Human   749 PMTGVCVQQSPVA 761
            |...:....||.|
  Fly   901 PTITIHDTPSPTA 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DYRK1A	NP_001387.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..57		4/6 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..136		11/76 (14%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		9/72 (13%)
		PKc_DYRK1	148..484	CDD:271128	140/353 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..442		11/42 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..540		18/96 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..679		25/130 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..763		4/18 (22%)
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	137/334 (41%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840