| Sequence 1: | NP_001387.2 | Gene: | DYRK1A / 1859 | HGNCID: | 3091 | Length: | 763 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001260456.1 | Gene: | Dyrk2 / 34831 | FlyBaseID: | FBgn0016930 | Length: | 757 | Species: | Drosophila melanogaster |
| Alignment Length: | 671 | Identity: | 230/671 - (34%) |
|---|---|---|---|
| Similarity: | 333/671 - (49%) | Gaps: | 139/671 - (20%) |
- Green bases have known domain annotations that are detailed below.
|
Human 76 MLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYND-- 138
Human 139 -GYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI 202
Human 203 EVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQ 267
Human 268 QM--CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSP 330
Human 331 EVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395
Human 396 EKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRML 460
Human 461 DYDPKTRIQPYYALQHSFFKKTAD---EGTNTSNSVSTSPAMEQSQSS----------GT----- 507
Human 508 TSSTSSSSGGSSGTSNSGRARSDP---THQHRHSGGHFTAAVQAMDCETHSPQ---VRQQFPAPL 566
Human 567 GWSGTEAPTQVTVETHPV-----QETTFHVAPQQ-------------NALHHHHGNS--SHHHH- 610
Human 611 --HH-----------HHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSST 662
Human 663 TSSSTSSSSTGNQGNQAYQNR 683 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| DYRK1A | NP_001387.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 32..57 | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 115..136 | 3/20 (15%) | |||
| Bipartite nuclear localization signal. /evidence=ECO:0000255 | 117..134 | 3/16 (19%) | |||
| PKc_DYRK1 | 148..484 | CDD:271128 | 149/337 (44%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 408..442 | 9/33 (27%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 485..540 | 17/72 (24%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 596..679 | 26/98 (27%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 744..763 | ||||
| Dyrk2 | NP_001260456.1 | PKc_DYRK4 | 186..529 | CDD:271127 | 164/379 (43%) |
| S_TKc | 233..529 | CDD:214567 | 147/321 (46%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG0667 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R968 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.840 | |||||