Protein Alignment DYRK1A and dyrk1ab

DIOPT Version :10

• Sequence 1: NP_001387.2
• Gene: DYRK1A / 1859
• HGNCID: 3091
• Length: 763
• Species: Homo sapiens
• Sequence 2: NP_001334760.1
• Gene: dyrk1ab / 327466
• ZFINID: ZDB-GENE-030131-5677
• Length: 719
• Species: Danio rerio
• Alignment Length: 738
• Identity: 603/738 - (81%)
• Similarity: 639/738 - (86%)
• Gaps: 23/738 - (3%)

Human    30 MAGQMPHSH-QYSDRRQPNISDQQVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPL 93
            ||..||||| ||||..|.: :||.|:.|.||||.|.         :...||.|||.||||..|||
Zfish     1 MAAPMPHSHQQYSDCHQQS-TDQSVTVLPYSDQTQA---------LTASQRHMPQCFRDPTLAPL 55

Human    94 RKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDR 158
            ||||:||||||||||||||||||||||||||:||||||||||:||||||:||||:||||||||||
Zfish    56 RKLSIDLIKTYKHINEVYYAKKKRRHQQGQGEDSSHKKERKVFNDGYDDENYDYVVKNGEKWMDR 120

Human   159 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVH 223
            |||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||
Zfish   121 YEIDSLIGKGSFGQVVKAYDRAEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVH 185

Human   224 LKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 288
            |||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||
Zfish   186 LKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLATPELSIIHCDL 250

Human   289 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVE 353
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   251 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVE 315

Human   354 MHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPP 418
            ||||||||||||||||||||||||||||.||:|.|||||||||||.||||::|||||||| ||||
Zfish   316 MHTGEPLFSGANEVDQMNKIVEVLGIPPNHIMDLAPKARKFFEKLSDGTWSIKKTKDGKR-YKPP 379

Human   419 GTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTA 483
            .:||||.|||||.|||||||||||||.|||||||||||||||||||||||||||||||||||||.
Zfish   380 ASRKLHAILGVECGGPGGRRAGESGHAVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTT 444

Human   484 DEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQA 548
            |||||||:|||||||:|||||||||||||||||||||||.||||||||||.||||.|||..|:.|
Zfish   445 DEGTNTSSSVSTSPALEQSQSSGTTSSTSSSSGGSSGTSTSGRARSDPTHHHRHSSGHFGTAMPA 509

Human   549 MDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQ-NALHHHHGNSSHHHHHH 612
            :||:...||.||.:..|:.|.|...|..|||||||||||||||.||. .|||       .|||||
Zfish   510 IDCDNLCPQARQPYHPPVVWPGIVGPEPVTVETHPVQETTFHVPPQHPKALH-------PHHHHH 567

Human   613 HHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGN 677
            |||||||| |.:..|.|||:|||||||:||||||||.|.|.||||||||.:|||||||||||.||
Zfish   568 HHHHHHHG-QVIATRPRPRLYNSPTNSASTQDSMEVVHGHLSMTSLSSSASSSSTSSSSTGNHGN 631

Human   678 QAYQNRPVAANTLDFGQNG--AMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLTMR 740
            ||||.|.:.||||||.|||  :|.:.|..:||||||||:||:|||..:.|||..|::.||||.||
Zfish   632 QAYQLRHLPANTLDFSQNGSLSMSMGLGAFSNPRQETGMAGNPTYPVATNTGTGHFIAEGHLGMR 696

Human   741 QGADREESPMTGVCVQQSPVASS 763
            ||.|||:|||||||||||.:|||
Zfish   697 QGIDREDSPMTGVCVQQSSMASS 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DYRK1A	NP_001387.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	32..57		13/25 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..136		19/20 (95%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		15/16 (94%)
		PKc_DYRK1	148..484	CDD:271128	320/335 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..442		28/33 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..540		50/54 (93%)
		Histidine-rich domain (HRD). /evidence=ECO:0000269|PubMed:29849146	595..625		17/30 (57%)
		Disordered. /evidence=ECO:0000269|PubMed:29849146	596..679		59/82 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	744..763		15/18 (83%)
dyrk1ab	NP_001334760.1	PKc_DYRK1	107..445	CDD:271128	323/338 (96%)