DRSC/TRiP Functional Genomics Resources

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Protein Alignment DYRK1A and ppk15

DIOPT Version :10

Sequence 1:NP_001387.2 Gene:DYRK1A / 1859 HGNCID:3091 Length:763 Species:Homo sapiens
Sequence 2:NP_593830.1 Gene:ppk15 / 2542228 PomBaseID:SPAC823.03 Length:534 Species:Schizosaccharomyces pombe


Alignment Length:463 Identity:168/463 - (36%)
Similarity:246/463 - (53%) Gaps:72/463 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    91 APLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIV------ 149
            :||..::|.|..||...|..:....::..::     ...|....|:|.|:|:.|:||::      
pombe    63 SPLEAMTVKLADTYSICNPKFQFSSEQNPRR-----PLTKPSEGVHNHGFDNVNHDYVLYVNDLL 122

Human   150 --KNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELM-N 211
              ..|.|    |.|...:|.|:||||.:..|...|:.||||:||||.||.||..:||.:|||: |
pombe   123 GTDEGRK----YLILDTLGHGTFGQVARCQDLKTQQIVAIKVIKNKPAFYNQCVMEVSILELLNN 183

Human   212 KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQM--CTALL 274
            |:|.|.|.:::.|...||.:||||||||:||.|||:|::...|||:.|:|.|.||.|:  ||:||
pombe   184 KYDPEDKRHLIRLYDQFMHKNHLCLVFELLSINLYELIKQNQFRGLHLSLVRSFATQLLSCTSLL 248

Human   275 FLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYD 339
                .:..|||||||||||||.:.....:|::||||:|...|.:|.||||||||||||:||:.|:
pombe   249 ----KQARIIHCDLKPENILLQDLSSPIVKVIDFGSACHERQTVYTYIQSRFYRSPEVILGLHYN 309

Human   340 LAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWN 404
            ..||||||||||.|:..|.|||.|.:|.:|:.:||::||.||..:|:....::|::.   .|..|
pombe   310 CGIDMWSLGCILAELFLGLPLFPGNSEYNQLCRIVDMLGNPPTWMLEMGKNSKKYYN---SGFVN 371

Human   405 LKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGES--GHTVADY-----------------L 450
            .:||.:.|       :.:..:|...:|..||.:..||.  ...|.:|                 |
pombe   372 GRKTYELK-------SIEQFSIENNKTEQPGKQYFGEKTLDAIVLNYPRRKTTPKLTPEEHEERL 429

Human   451 KFKDLILRMLDYDPKTRIQPYYALQHSFF-------------------KKTADEGTNTSNSVSTS 496
            .|.|.|.:.|:.:|..|..|..|..|.|.                   ::|.:......|.....
pombe   430 CFIDFIKQFLELNPLKRWTPDQAKNHPFITGASFSQYCIDKQKPLLTTQRTRNRSHTIGNQAVVP 494

Human   497 PAMEQSQS 504
            |:::::.:
pombe   495 PSLQRAST 502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DYRK1ANP_001387.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 32..57
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 115..136 1/20 (5%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 117..134 1/16 (6%)
PKc_DYRK1 148..484 CDD:271128 151/384 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..442 7/33 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 485..540 2/20 (10%)
Histidine-rich domain (HRD). /evidence=ECO:0000269|PubMed:29849146 595..625
Disordered. /evidence=ECO:0000269|PubMed:29849146 596..679
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 744..763
ppk15NP_593830.1 PKc_YAK1 130..458 CDD:271114 147/341 (43%)
Blue background indicates that the domain is not in the aligned region.

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