Protein Alignment DYRK1A and mbk-1

DIOPT Version :10

• Sequence 1: NP_001387.2
• Gene: DYRK1A / 1859
• HGNCID: 3091
• Length: 763
• Species: Homo sapiens
• Sequence 2: NP_510460.2
• Gene: mbk-1 / 181578
• WormBaseID: WBGene00003149
• Length: 882
• Species: Caenorhabditis elegans
• Alignment Length: 734
• Identity: 321/734 - (43%)
• Similarity: 392/734 - (53%)
• Gaps: 154/734 - (20%)

Human    83 QTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERK------------- 134
            |.||:|..||:|||:.|||||||.|||.:|.:|:.|..:.:..|:...|..|
 Worm   180 QQFRNPQDAPVRKLTSDLIKTYKAINESFYLRKQVRRDRHKSQDAGKPKGSKDGSGASLTDTFSI 244

Human   135 ---------------------------------------------------------VYNDGYDD 142
                                                                     .||:||||
 Worm   245 HNAIPITSSDNHYQQDAHQNAPPLLDTNAPPTSTMVVPMRTETDLQQQQRQKSSRGGPYNNGYDD 309

Human   143 DNYDYIVKNGEKWMDRYEI--DSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVR 205
            .|||||:||||.:..||.|  |:.:||||||||.||||.:.:|.||||||||||.|.:|||||:.
 Worm   310 QNYDYILKNGEIFDKRYVILSDTPVGKGSFGQVTKAYDTLNKEEVAIKIIKNKKTFFDQAQIEIH 374

Human   206 LLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMC 270
            ||||.|.||.:.||.||.||.||:.|.|||||||:|||||||||:||:||||||||.||||||:.
 Worm   375 LLELTNAHDKDNKYNIVTLKGHFVHRAHLCLVFELLSYNLYDLLKNTSFRGVSLNLARKFAQQLG 439

Human   271 TALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLG 335
            ..||||::||||||||||||||:||.|.|||.|:::|||||||.|.|||||||||||||||||||
 Worm   440 KTLLFLSSPELSIIHCDLKPENVLLVNAKRSQIRVIDFGSSCQTGHRIYQYIQSRFYRSPEVLLG 504

Human   336 MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPD 400
            :.||..||||||||||||||||||||:|::|||||.|||||||:||..:||..||..|:|:|..|
 Worm   505 IAYDTKIDMWSLGCILVEMHTGEPLFAGSSEVDQMMKIVEVLGMPPKEMLDIGPKTHKYFDKTED 569

Human   401 GTWNLKKTKDGKRE-YKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDP 464
            |.:..|||:||.|. ||.||.||||.||||.:|||||||.||.||:|.||.||||||.|||.:||
 Worm   570 GIYYCKKTRDGYRHTYKAPGARKLHEILGVTSGGPGGRRLGEPGHSVEDYSKFKDLIKRMLQFDP 634

Human   465 KTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQ-------------------------- 503
            |.||.|||.::|.|.|: .:|...:...||.|...:|.|
 Worm   635 KQRISPYYVVRHPFLKQ-KEERVPSQPPVSHSNLQQQQQLYIQQPSSQMSQVMESPSVGSVYVED 698

Human   504 ----------SSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQV 558
                      |:...|.|||...|.:...::||.|.....|:.|:..:..:..|....:.:....
 Worm   699 NGMYRQAPGSSANPISVTSSFDEGDAMEVDAGRRRFSAHQQNYHNPNYQYSQPQQQQQQQYQQTQ 763

Human   559 RQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQA 623
            |.|    |.....:|..|..::...:|:   ....||...|.....||             .||.
 Worm   764 RTQ----LEQQQKQAQLQQQLQQQQMQQ---QQQQQQQRQHMPQAQSS-------------SQQH 808

Human   624 LGNRTRPRV--YNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQ----------G 676
            |.:|.|||.  .|...|.....|:.:          ........|.|:..:.||          |
 Worm   809 LQSRARPRQQDQNEWRNQFELDDTFQ----------QKQRKVDDSVSNQISRNQFNPQQVSMTHG 863

Human   677 NQAYQNRPVAANTLDFGQN 695
            |....||.:  ..||:..|
 Worm   864 NVNANNREM--EKLDYPNN 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DYRK1A	NP_001387.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	32..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..136		5/90 (6%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		3/16 (19%)
		PKc_DYRK1	148..484	CDD:271128	236/338 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..442		24/34 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..540		17/90 (19%)
		Histidine-rich domain (HRD). /evidence=ECO:0000269|PubMed:29849146	595..625		6/29 (21%)
		Disordered. /evidence=ECO:0000269|PubMed:29849146	596..679		19/94 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	744..763
mbk-1	NP_510460.2	PKc_DYRK1	312..651	CDD:271128	238/338 (70%)