Protein Alignment DYRK1A and Dyrk1a

DIOPT Version :10

• Sequence 1: NP_001387.2
• Gene: DYRK1A / 1859
• HGNCID: 3091
• Length: 763
• Species: Homo sapiens
• Sequence 2: NP_031916.1
• Gene: Dyrk1a / 13548
• MGIID: 1330299
• Length: 763
• Species: Mus musculus
• Alignment Length: 763
• Identity: 757/763 - (99%)
• Similarity: 759/763 - (99%)
• Gaps: 0/763 - (0%)

Human     1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSDQIQQP 65
            |||||||||||||||||||||||||||||||.||||||||||||||:|||||||||.||||||||
Mouse     1 MHTGGETSACKPSSVRLAPSFSFHAAGLQMAAQMPHSHQYSDRRQPSISDQQVSALPYSDQIQQP 65

Human    66 LTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHK 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 LTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHK 130

Human   131 KERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKA 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 KERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKA 195

Human   196 FLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLN 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 FLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLN 260

Human   261 LTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSR 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 LTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSR 325

Human   326 FYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPK 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 FYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPK 390

Human   391 ARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDL 455
            |||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 ARKFFEKLPDGTWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDL 455

Human   456 ILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSG 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 ILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSG 520

Human   521 TSNSGRARSDPTHQHRHSGGHFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQ 585
            ||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||
Mouse   521 TSNSGRARSDPTHQHRHSGGHFAAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQ 585

Human   586 ETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGH 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 ETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGH 650

Human   651 SHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIA 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   651 SHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIA 715

Human   716 GHPTYQFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS 763
            ||||||||||||||||||||||.|||||||||||||||||||||||||
Mouse   716 GHPTYQFSANTGPAHYMTEGHLAMRQGADREESPMTGVCVQQSPVASS 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DYRK1A	NP_001387.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	32..57		22/24 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..136		20/20 (100%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		16/16 (100%)
		PKc_DYRK1	148..484	CDD:271128	334/335 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..442		33/33 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..540		54/54 (100%)
		Histidine-rich domain (HRD). /evidence=ECO:0000269|PubMed:29849146	595..625		29/29 (100%)
		Disordered. /evidence=ECO:0000269|PubMed:29849146	596..679		82/82 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	744..763		18/18 (100%)
Dyrk1a	NP_031916.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..61		25/27 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..136		20/20 (100%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		16/16 (100%)
		PKc_DYRK1	148..484	CDD:271128	334/335 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..442		33/33 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..540		54/54 (100%)
		Histidine-rich domain (HRD). /evidence=ECO:0000250|UniProtKB:Q13627	595..625		29/29 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..679		82/82 (100%)