DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde4b and Pde11

DIOPT Version :9

Sequence 1:	XP_006502918.1	Gene:	Pde4b / 18578	MGIID:	99557	Length:	736	Species:	Mus musculus
Sequence 2:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster

Alignment Length:	822	Identity:	177/822 - (21%)
Similarity:	299/822 - (36%)	Gaps:	220/822 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse    14 DNLKDYFECSLSKSYSSSSYTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGIS------ 72
            |.||   :|.:||.:..              |....::    ...|.:..|...|.||:
  Fly   453 DGLK---KCLVSKLFDV--------------CPRSTVE----EMEQQDEVRVAWGTGIAGHVAES 496

Mouse    73 -RPTTLPLTTLPSIAITTVSQECFDVENGPSPG---RSPLDPQAGSSSGLVLHAAFPGHSQRRES 133
             .|..:|         .....|.|:.|.....|   ::.|......|||.|:..|...:....|.
  Fly   497 GEPVNIP---------DAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGEC 552

Mouse   134 FLYRSDSDYDLSPKAMS----------RNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTLLTN 188
            |       .::..|..|          ||:.|..:                |...::.|..||
  Fly   553 F-------SEIDEKVFSSYLQFCGIGLRNAQLYEK----------------SQLEIKRNQVLL-- 592

Mouse   189 LHGAPNKRSPAASQAPVSRVSLQEESYQKLAMETLEELDW-------CLDQLETIQTYRSVSEMA 246
                           .::|:..:|:|       |:|.:.:       .|.|.:.:|.. .|.|..
  Fly   593 ---------------DLARMIFEEQS-------TIEHMVFRILTHMQSLIQCQRVQIL-LVHEAD 634

Mouse   247 SNKFKRMLNRELTHLSE---MSRSGNQVSEY-----ISNTFLDKQNDVEIPSPTQKDR------E 297
            ...|.|:.:.|...|||   .||:....|.:     |:.........|.:|:..:.||      |
  Fly   635 KGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDE 699

Mouse   298 KK--KKQQLMT--------QISGVKKLMHS-SSLNNTS-----ISRF----GVNTENEDHLAKEL 342
            ..  |.:.::.        ||.||.:|::. :.|:.|.     :..|    |:...|.....|.:
  Fly   700 NSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAI 764

Mouse   343 EDLNKWGLNIFNVAGYSHNRPL------------------------------------TCIMYAI 371
            ..:.|..:.: .|..|..:..:                                    .|:  .:
  Fly   765 VAMAKQSVTL-EVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACL--RM 826

Mouse   372 FQERDLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEI 436
            |.:.|.::.|.|..:....::::::.:|. :|.|||..||.:|||....:|:|.....:|.::|.
  Fly   827 FLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIEC 890

Mouse   437 LAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFQNLTKK 501
            ||.|.....||:||.|.:|.|.|..:|.||.:|: .|.:|:||......:|......|..||:..
  Fly   891 LALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPGNQILANLSSD 954

Mouse   502 QRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLR--NMVHCAD 564
            ....:.:::.|.:|:||::.:.......  :....:.||..|.     .:...:||  :|..| |
  Fly   955 DYCRVIRVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWVA-----EEPRALLRAMSMTVC-D 1011

Mouse   565 LSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP---MCDKHTASVEKSQVGFIDYIVHPL 626
            ||..||..|:.::..|.:..|||:|||.|::. :.|:|   |..:....:...||.|||.|..|:
  Fly  1012 LSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMNREKEDELPMMQVNFIDSICLPI 1075

Mouse   627 WETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDERSRDCQG-LMEKFQFELTLEEEDSE 690
            :|.:|.|        .|.||                ||.|..||.:| .::......|...:|.|
  Fly  1076 YEAFATL--------SDKLE----------------PLVEGVRDNRGHWIDLADVVKTKTSQDQE 1116

Mouse   691 GPEKEGEGHSYFSSTKTLCVIDPENRDSLEETDIDIATEDKS 732
             ||:|.:..:..|:.....:.|.:...|..|..:|..:|..|
  Fly  1117 -PEEEQQQQNVISNGDCKAMSDDDVAASEAEVAVDSPSEKAS 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde4b	XP_006502918.1	PDE4_UCR	166..281	CDD:375549	24/129 (19%)
Pde4b	XP_006502918.1	PDEase_I	405..646	CDD:365964	74/245 (30%)
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	31/181 (17%)
		GAF	611..762	CDD:214500	31/151 (21%)
		PDEase_I	859..1094	CDD:278654	79/268 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820