Protein Alignment Cdk18 and Cdk4

DIOPT Version :10

• Sequence 1: NP_032821.1
• Gene: Cdk18 / 18557
• MGIID: 97518
• Length: 451
• Species: Mus musculus
• Sequence 2: NP_477196.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Alignment Length: 320
• Identity: 127/320 - (39%)
• Similarity: 186/320 - (58%)
• Gaps: 30/320 - (9%)

Mouse   103 RMSRRASLSD---IGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLE-HEEGAPCT 163
            |..:|..:|.   .|.|....|.:|:.:|||.|.||::.|..:|.|:||||::|:. :|.|.|.:
  Fly     5 RQLKRQKMSQAKKFGDGDPFNYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMS 69

Mouse   164 AIREVSLLKDL---KHANIVTLHDL---IHTDRSL--TLVFEYLDSDLKQYLDHCGNL-MNMHNV 219
            .:||:||||.|   .|||||.|:::   :..|..|  .||||:::.||...:|..... |:...:
  Fly    70 TLREISLLKQLNASNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTI 134

Mouse   220 KIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNE------V 278
            :....:||.|:.:.|..:|:||||||||||::.:|.||:||||||       |||.:|      |
  Fly   135 QRLSRELLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLA-------KTYGSEMKLTSVV 192

Mouse   279 VTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGKPLFPGSTVKEELHLIFRLLGTPTEESWP 343
            ||||||.|:||| :..|::.:|:|...||::||...:.||||::.|.:|..||.|.|.|||:.||
  Fly   193 VTLWYRAPEVLL-AQPYNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWP 256

Mouse   344 GVTSISEFRAYNFPRYLPQPLLSHAPRLDTEGINLLSSLLLYESKSRMSAEAALNHPYFQ 403
            ...|::   ..:||:..|:......|.|.....:||:.:|.|:...|.||.|.|.|.|||
  Fly   257 QTISVA---LEHFPQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYFQ 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk18	NP_032821.1	Protein Kinases, catalytic domain	115..402	CDD:473864	120/302 (40%)
Cdk4	NP_477196.1	STKc_CDK4_6_like	26..312	CDD:270831	119/296 (40%)