DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pcsk5 and Fur2

DIOPT Version :9

Sequence 1:	NP_001177412.1	Gene:	Pcsk5 / 18552	MGIID:	97515	Length:	1877	Species:	Mus musculus
Sequence 2:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster

Alignment Length:	1944	Identity:	582/1944 - (29%)
Similarity:	760/1944 - (39%)	Gaps:	714/1944 - (36%)

- Green bases have known domain annotations that are detailed below.

Mouse    36 VYTNHWAVKIAGGFAEADRIASKYGFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEP 100
            :|||.:||.|..|...||.||:|:||||.||||:|.:||.|.|....|||:.|||.....:..|.
  Fly   238 IYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSEN 302

Mouse   101 KVEWIQQQVVKKRTKRD-----------YDL-------------------------SHAQ----- 124
            :|:|:|||..|.|.|||           |:|                         ||:|
  Fly   303 EVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYR 367

Mouse   125 --STY--FNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQ 185
              |::  |.||.:...||:...:.......|||:..||::|||||.:||:||||||:..||||.|
  Fly   368 DVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQ 432

Mouse   186 NYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGD 250
            |||..||.|:||||.||.|:  .:.:|||||||||||||.|.|:.|.||:|:||.|||||||||.
  Fly   433 NYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGK 495

Mouse   251 VTDMVEAKSVSYNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGN 315
            |.|:|||:::|.||.|:.||||||||:|||.|||||.||.|:||..||..||:|.||:|||||||
  Fly   496 VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGN 560

Mouse   316 GGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSG-ESYDKKIITTDL--- 376
            |||..|.|:||||||||:|:||||..::|.||||||||||||||||||| ..:||.:.|.|:
  Fly   561 GGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGS 625

Mouse   377 ---RQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHL-NANDWKTNAAG 437
               ...||..|||||||||:||||.||||||||.|||||:|:::|.|||...| ..|.|..|...
  Fly   626 LRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTLNGVK 690

Mouse   438 FKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVC---VESTDRQIKTIRPNSAVRSIYKASGCSDN 499
            .|.||.:|:|||||.|||..||:||:||.||:|   ..:.||:|.... .|.:.:....:||:..
  Fly   691 RKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAY-GSTLSTHMDVNGCAGT 754

Mouse   500 PNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGE 564
            .| .|.|||||..|||:....||:|.|.||||.||.|.||..|..|.....|.:|.|:::|.|||
  Fly   755 IN-EVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHFWGE 818

Mouse   565 RAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPY--------------SPTNEFPKVE 615
            :|.|.|.|:|.:  ...|....||.|.:|.|:.||||.||.              ||::..|
  Fly   819 KAEGRWTLQVIN--GGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSSPQLRSPSSSNP--- 878

Mouse   616 RFRYSRVEDPTDDYGAEDYAGPCDPECSEVGCDGPGPDHCSDCLHYYYKLKNNTRICVSSCPPGH 680
             |.:                    |..|.:|  .|..:                        .|:
  Fly   879 -FLF--------------------PSASNIG--QPANE------------------------GGN 896

Mouse   681 YHADKKRCRKCAPNCESCFGSHGNQCLSCKYGYFLNEETSSCVTQCPDGSYEDIKKNVCGKCSEN 745
            ::.|                         .:..:||              |::|..: .|...|.
  Fly   897 FNTD-------------------------SFASYLN--------------YQNIFSS-AGSDPEP 921

Mouse   746 CKACIGFHNCTECKGGLSLQGSRCSVTCEDGQFFNGHDCQPCHRFCATCSGAGADGCINCTEGYV 810
            ..|.:...|.|                                  .|...|:.|:..     |:.
  Fly   922 ATATLDGQNVT----------------------------------AAIAGGSSAESL-----GFT 947

Mouse   811 MEEGRCVQSCSVSYYLDHSSEGGYKSCKRCDNSCLTCNGPGFKNCSSCPSGYLLDLGTCQMGAIC 875
            ....:.|.:       ..:.:|..|....||..|
  Fly   948 ASAAQLVAA-------PETRDGDKKILHSCDAEC------------------------------- 974

Mouse   876 KDGEYIDDQGHCQTCEASCAKCW--GPTQEDCISCPVTRVLDDGRCVMNCPSWKFEFKKQ-CHPC 937
                  |..|           |:  ||||  |::|...|:  |..||..||...|..:.. |.||
  Fly   975 ------DSSG-----------CYGRGPTQ--CVACSHYRL--DNTCVSRCPPRSFPNQVGICWPC 1018

Mouse   938 HYTCQGCQGSGPSNCTSCRADKHGQERFLYHGECLENCPVGHYPAKGH-----ACLP-CPDNCEL 996
            |.||:.|.|:||.:|.:|.                        ||..|     .||. |||
  Fly  1019 HDTCETCAGAGPDSCLTCA------------------------PAHLHVIDLAVCLQFCPD---- 1055

Mouse   997 CYNPHVCSRCMSGYVIIPPNHTCQKLECRQGEFQDSEYEECMPCEEGCLGCTEDDPGACTSCATG 1061
                                          |.|::|....|:|||..|..| :|.|..||||...
  Fly  1056 ------------------------------GYFENSRNRTCVPCEPNCASC-QDHPEYCTSCDHH 1089

Mouse  1062 YYMFERHCYKACPEKTFGVKWECRACGTNCGSCDQHECYWCEEGFFLSGGSCVQDCGPGFHGDQE 1126
            ..|.|..||.|||..|                      |..|:
  Fly  1090 LVMHEHKCYSACPLDT----------------------YETED---------------------- 1110

Mouse  1127 LGECKPCHRACENCTGSGYNQCSSCQEGLQLWHGTCLWSTWPQVEGKDWNEAVPTEKPSLVRSLL 1191
                               |:|:.
  Fly  1111 -------------------NKCAF----------------------------------------- 1115

Mouse  1192 QDRRKWKVQIKRDATSQNQPCHSSCKTCNGSL---CASCPTGMYLWLQACVPSCPQGTWPSVTSG 1253
                                |||:|.||||..   |.:|.:..|.|...|:.|||.|.:......
  Fly  1116 --------------------CHSTCATCNGPTDQDCITCRSSRYAWQNKCLISCPDGFYADKKRL 1160

Mouse  1254 SCEKCSEDCVSCSGADLCQQCLSQPDNTLLLHEGRCYHSCPEGFYAKDGVCEHCSSPCKTCEGNA 1318
            .|..|.|.|.:|:...:|.:||   .|..|....:|..|..||          ||
  Fly  1161 ECMPCQEGCKTCTSNGVCSECL---QNWTLNKRDKCIVSGSEG----------CS---------- 1202

Mouse  1319 TSCNSCEGDFVLDHGVCWKTCPEKHVAVEGVCKHCPERCQDCIHEKTCKECMPDFFLYNDMCHRS 1383
                  |.:|              :..|||
  Fly  1203 ------ESEF--------------YSQVEG----------------------------------- 1212

Mouse  1384 CPKSFYPDMRQCVPCHKNCLECNGPKEDDCKVCADTSKALHNGLCLDECPEGTYKEEENDECRDC 1448
                      ||.|||.:|..||||        ||||                        |..|
  Fly  1213 ----------QCRPCHASCGSCNGP--------ADTS------------------------CTSC 1235

Mouse  1449 PESCLICSSAWTCLA-CREGFTVVHDVCTAPKECAAVEYWDEGSHRCQPCHKKCSRCSGPSEDQC 1512
            |.:.|:..|  .|:: |||||.|                  |....|.||...||:|  .|...|
  Fly  1236 PPNRLLEQS--RCVSGCREGFFV------------------EAGSLCSPCLHTCSQC--VSRTNC 1278

Mouse  1513 YTCPRETFLLNTTCVKECPEGYHTDKDSQQCVLCHSSCRTCEGPHSMQCLSCRPGWFQLGKECLL 1577
            ..|.:...|.|..|...|.:||::|:..  |..|:.||.||.||...||:.|..||.....||..
  Fly  1279 SNCSKGLELQNGECRTTCADGYYSDRGI--CAKCYLSCHTCSGPRRNQCVQCPAGWQLAAGECHP 1341

Mouse  1578 QCRDGYYGESTSGRCEKCDKSCKSCRGPRPTDCQSCDTFFFLLRSKGQCHRACPEHYYADQHAQT 1642
            :|.:|:| :|..| |:||...||:|....|..|.|                 ||.|...|
  Fly  1342 ECPEGFY-KSDFG-CQKCHHYCKTCNDAGPLACTS-----------------CPPHSMLD----- 1382

Mouse  1643 CERCHPTCDKCSGKEAWSCLSCVWSYHLLKGICIPECIVGEYREGKGENFNCKKCHESCMECKGP 1707
                                         .|:|: ||:..:|.:  ..:..||.||:||..|.||
  Fly  1383 -----------------------------GGLCM-ECLSSQYYD--TTSATCKTCHDSCRSCFGP 1415

Mouse  1708 GSKNCTGCSAGLLLDMDDNRCLHCC---NASHSRRSQDCCDCQSSTDEC-----------ILPAR 1758
            |..:|.||...|.||..:::|:.||   ..:....|..||:|...|.||           ::.:.
  Fly  1416 GQFSCKGCVPPLHLDQLNSQCVSCCQNQTLAEKTSSAACCNCDGETGECKATSTGGKRRTVVGSG 1480

Mouse  1759 EAEFYEHTK---------------------TALLVTSGAMLLLLLGAAAVVWR--KSRSRPVAKG 1800
            .|.....:|                     ||:...:.|:.||::...::::.  :..|..|::.
  Fly  1481 SAYKSSESKHGSFENDGNAREFVLRLDSPLTAITAIAVAICLLIITIFSIIFAVLQRNSNHVSRN 1545

Mouse  1801 --RYEKLAEPTVSYSSYRSSYLDEDQVIEYR-------DRDYDEDDEDDIVYMGQDGTV 1850
              ||.|:|    :.||.|...|......:.|       |.|.|.|:.||.:    ||.|
  Fly  1546 SVRYRKIA----NTSSGRRKNLSAKPTSDARFIFNIGEDDDTDGDNSDDEL----DGNV 1596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pcsk5	NP_001177412.1	S8_pro-domain	40..116	CDD:293079	36/75 (48%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	128..422	CDD:173789	188/300 (63%)
		Peptidase_S8	164..447	CDD:278510	185/290 (64%)
		P_proprotein	507..597	CDD:279782	40/89 (45%)
		Cell attachment site. /evidence=ECO:0000255	521..523		1/1 (100%)
		FU 1	632..682		5/49 (10%)
		FU	637..687	CDD:238021	6/49 (12%)
		CRM (Cys-rich motif)	638..1753		231/1130 (20%)
		FU	690..739	CDD:238021	4/48 (8%)
		Furin-like_2	695..786	CDD:292535	9/90 (10%)
		FU	781..825	CDD:214589	5/43 (12%)
		GF_recep_IV	786..906	CDD:291509	17/121 (14%)
		FU	835..880	CDD:214589	4/44 (9%)
		FU	885..928	CDD:214589	14/44 (32%)
		FU	931..980	CDD:214589	12/49 (24%)
		FU	1036..1078	CDD:214589	19/41 (46%)
		Furin-like_2	1043..1130	CDD:292535	18/86 (21%)
		FU	1128..1165	CDD:214589	2/36 (6%)
		FU	1211..1256	CDD:238021	17/47 (36%)
		Furin-like_2	1214..1305	CDD:292535	29/93 (31%)
		FU	1301..1343	CDD:214589	4/41 (10%)
		Furin-like_2	1357..1445	CDD:292535	14/87 (16%)
		FU	1397..1446	CDD:238021	12/48 (25%)
		FU	1491..1535	CDD:214589	14/43 (33%)
		GF_recep_IV	1496..1611	CDD:291509	42/114 (37%)
		FU	1546..1593	CDD:238021	19/46 (41%)
		FU	1594..1644	CDD:238021	12/49 (24%)
		GF_recep_IV	1595..1712	CDD:291509	26/116 (22%)
		FU	1642..1684	CDD:214589	4/41 (10%)
		FU	1694..1736	CDD:214589	19/44 (43%)
		AC 1	1825..1844		7/25 (28%)
		AC 2	1856..1877
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	36/75 (48%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	188/300 (63%)
		Peptidase_S8	411..700	CDD:278510	185/290 (64%)
		P_proprotein	761..849	CDD:279782	40/89 (45%)
		Furin-like	966..1126	CDD:279142	73/394 (19%)
		FU	970..1013	CDD:238021	19/94 (20%)
		FU	1017..1067	CDD:238021	22/107 (21%)
		FU	1063..1106	CDD:214589	20/65 (31%)
		GF_recep_IV	1068..1232	CDD:291509	75/408 (18%)
		FU	1116..1163	CDD:238021	17/46 (37%)
		FU	1211..1255	CDD:214589	26/122 (21%)
		FU	1259..1301	CDD:214589	14/43 (33%)
		FU	1304..1348	CDD:214589	17/45 (38%)
		FU	1356..1403	CDD:238021	17/100 (17%)
		FU	1401..1444	CDD:214589	19/42 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2589
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21244
Inparanoid	1	1.050	771	1.000	Inparanoid score	I534
Isobase	1	0.950	-	0	Normalized mean entropy	S3236
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	1	1.000	-	-		otm43363
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4005
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.720