DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pcsk4 and Fur2

DIOPT Version :9

Sequence 1:	XP_006513421.1	Gene:	Pcsk4 / 18551	MGIID:	97514	Length:	679	Species:	Mus musculus
Sequence 2:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster

Alignment Length:	663	Identity:	294/663 - (44%)
Similarity:	379/663 - (57%)	Gaps:	104/663 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse    30 IYVSSWAVRVTKGYQEAERLARKFGFVNLGQIFPDDQYFHLRHRGVAQQSLTPHWGHRLRLKKDP 94
            ||.:.:||.:..|.|.|:.:|.|.||:|.|||...|.|:..:|..|:::||.....|:..||.:.
  Fly   238 IYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSEN 302

Mouse    95 KVRWFEQQTLRRRVKRS---------------------LVVPT---------------------- 116
            :|:|.:||..:.|.||.                     :|.|.
  Fly   303 EVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYR 367

Mouse   117 ---------DPWFSKQWYM-----NKEIQQDLNILKAWNQGLTGRGVVISILDDGIEKDHPDLWA 167
                     ||.|.:|||:     ..:...|:|:..||.:|.||:|||:|||||||:.:||||..
  Fly   368 DVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQ 432

Mouse   168 NYDPLASYDFNDYDPDPQPRYTPNDENRHGTRCAGEVSATANNGFCGAGVAFNARIGGVRMLDGA 232
            ||||.||:|.|..|.||.|:  .|.:|:|||||||||:|.|.|.|||.|||:||.|||||||||.
  Fly   433 NYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGK 495

Mouse   233 ITDIVEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGLLTQEAFRRGVTKGRQGLGTLFIWASGN 297
            :.|:||||:|||.|.||.||||||||||||.||||||.|.:.||..|||.||||.|::|:|||||
  Fly   496 VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGN 560

Mouse   298 GGLHYDNCNCDGYTNSIHTLSVGSTTRQGRVPWYSEACASTFTTTFSSGVV-TDPQIVTTDL--- 358
            ||.:.|:||||||||||.|||:.|.|:.|..|||.|.|:||..||:|||.. .|..:.|.|:
  Fly   561 GGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGS 625

Mouse   359 ---HHQCTDKHTGTSASAPLAAGMIALALEANPLLTWRDLQHLVVRASRPAQLQAED-WRINGVG 419
               .|.||.:|||||||||||||:.||||||||.|||||:|:|||..||||.|:.|: |.:|||
  Fly   626 LRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTLNGV- 689

Mouse   420 RQGAVGPGRGSGCGALRASDRYPSRAVSHHYGYGLLDAGLLVDLARVWLPTKPQKKCAIRVVHTP 484
                                   .|..||.:||||:|||.:|.||..|....||..|..|..:..
  Fly   690 -----------------------KRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNED 731

Mouse   485 TPI----LPRMLVPKNVTACSDGSRRRLIRSLEHVQVQLSLSYSRRGDLEIFLTSPMGTRSTLVA 545
            ..|    ...:....:|..|:.....  :|.|||||.:::|.:..||:|.|.|||||||.|||:.
  Fly   732 RKIDGAYGSTLSTHMDVNGCAGTINE--VRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLF 794

Mouse   546 IRPLDISGQGYNNWIFMSTHYWDEDPQGLWTLGLENKG--YYFNTGTLYYYTLLLYGTA-EDMTA 607
            .||.||....:::|.|:|.|:|.|..:|.|||.:.|.|  .....|.|..:.|:.|||: :.|..
  Fly   795 ERPRDIVKSNFDDWPFLSVHFWGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQPMRL 859

Mouse   608 RPQ----APQVTS 616
            :.:    :||:.|
  Fly   860 KSELLNSSPQLRS 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pcsk4	XP_006513421.1	S8_pro-domain	34..110	CDD:374560	27/75 (36%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	115..404	CDD:173789	184/331 (56%)
		P_proprotein	512..>577	CDD:366670	32/64 (50%)
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	27/75 (36%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	183/300 (61%)
		Peptidase_S8	411..700	CDD:278510	185/314 (59%)
		P_proprotein	761..849	CDD:279782	39/87 (45%)
		Furin-like	966..1126	CDD:279142
		FU	970..1013	CDD:238021
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833563
Domainoid	1	1.000	40	1.000	Domainoid score	I12484
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650