Protein Alignment Furin and Fur2

DIOPT Version :10

• Sequence 1: XP_011249120.1
• Gene: Furin / 18550
• MGIID: 97513
• Length: 803
• Species: Mus musculus
• Sequence 2: NP_727963.1
• Gene: Fur2 / 32604
• FlyBaseID: FBgn0004598
• Length: 1682
• Species: Drosophila melanogaster
• Alignment Length: 838
• Identity: 366/838 - (43%)
• Similarity: 428/838 - (51%)
• Gaps: 222/838 - (26%)

Mouse    27 QKIFTNTWAVHIPGGPAVADRVAQKHGFHNLGQI--FGDYYHFWHRAVTKRSLSPHRPRHSRLQR 89
            :.|:||.:||:||.|..:||.:|.||||.|.|||  ..:||.|.|..|:||||...|.....|:.
  Fly   236 EAIYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKS 300

Mouse    90 EPQVKWLEQQVAKRRAKRD-VYQE-PT-------------------------------------- 114
            |.:|||::||..|.|.||| .||: ||
  Fly   301 ENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRME 365

Mouse   115 -----------DPKFPQQWYL--------SGVTQRDLNVKEAWAQGFTGHGIVVSILDDGIEKNH 160
                       ||.|.:||||        .|:   |:||..||.:|:||.|:|||||||||:.||
  Fly   366 YRDVSSHFIFPDPLFKEQWYLVSKNGGAKDGL---DMNVGPAWQKGYTGKGVVVSILDDGIQTNH 427

Mouse   161 PDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGAPL 225
            ||||.||||.||||:|..|.||.|:  ...||:|||||||||||||.|..|||||||||.||
  Fly   428 PDLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIG--- 487

Mouse   226 FPPPLRPGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQ 290
                   |||||||:|.|.|||::|.|||:||.||||||||||||.|||||..||..||..||:.
  Fly   488 -------GVRMLDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTS 545

Mouse   291 GRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGN 355
            ||.|.|||||||||||||..||||||||||||:|||||||||.|..|||.|.||||||||||||.
  Fly   546 GRQGKGSIFVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGT 610

Mouse   356 Q-NEKQIVTTDLRQK------CTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKP 413
            . ::|.:.|.|:...      ||..||||||||||||||.||.||||..|||||||:|||.||:|
  Fly   611 PGHDKSVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRP 675

Mouse   414 AHLNADD-WATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVEPKDI----GK 473
            |.|..:: |..|||.||.||.:||||:||||||:||:.||:|.||..|......|.:.|    |.
  Fly   676 APLEKENGWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGS 740

Mouse   474 RLEVRKAVTACLGEPNHITRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGF 538
            .|.....|..|.|..|.:..|||||.|:||.:..||:|.|.|.|||||.||||..||.|.....|
  Fly   741 TLSTHMDVNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNF 805

Mouse   539 NDWAFMTTHSWDEDPAGEWVLEIEN--TSEANNYGTLTKFTLVLYGT------------------ 583
            :||.|::.|.|.|...|.|.|::.|  ....|..|.|:|:.|:.|||
  Fly   806 DDWPFLSVHFWGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSSPQL 870

Mouse   584 --------------------APEG----------------------------------------- 587
                                |.||
  Fly   871 RSPSSSNPFLFPSASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSDPEPATATLDGQNVTAAI 935

Mouse   588 -----------------LSTPPE-----------------SSGCKTLTSSQACVVCEEGYSLHQK 618
                             |...||                 ||||.....:| ||.|.. |.| ..
  Fly   936 AGGSSAESLGFTASAAQLVAAPETRDGDKKILHSCDAECDSSGCYGRGPTQ-CVACSH-YRL-DN 997

Mouse   619 SCVQHCPPGFIPQVLDTHYSTENDVEIIRASVCTPCHASCATCQGPAPTDCLSC-PSH 675
            :||..|||...|.               :..:|.|||.:|.||.|..|..||:| |:|
  Fly   998 TCVSRCPPRSFPN---------------QVGICWPCHDTCETCAGAGPDSCLTCAPAH 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Furin	XP_011249120.1	S8_pro-domain	33..107	CDD:465126	35/75 (47%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	113..412	CDD:173789	205/362 (57%)
		P_proprotein	494..580	CDD:460225	41/87 (47%)
		FU	591..629	CDD:214589	17/54 (31%)
		FU	648..>685	CDD:214589	14/29 (48%)
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:465126	35/75 (47%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	375..674	CDD:173789	203/313 (65%)
		P_proprotein	761..849	CDD:460225	41/87 (47%)
		GF_recep_IV	970..1073	CDD:464344	30/89 (34%)
		VSP	1020..1379	CDD:146106	10/21 (48%)
		FU	1401..1444	CDD:214589