Protein Alignment DVL1 and dvl1b

DIOPT Version :10

• Sequence 1: NP_001317240.1
• Gene: DVL1 / 1855
• HGNCID: 3084
• Length: 695
• Species: Homo sapiens
• Sequence 2: XP_005169354.2
• Gene: dvl1b / 560032
• ZFINID: ZDB-GENE-071004-1
• Length: 742
• Species: Danio rerio
• Alignment Length: 759
• Identity: 499/759 - (65%)
• Similarity: 574/759 - (75%)
• Gaps: 81/759 - (10%)

Human     1 MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFD 65
            |||||||||:|||||||||||.||||:|||||||||||||||::||||||||||||||||||:.|
Zfish     1 MAETKIIYHIDEEETPYLVKLSVAPEKVTLADFKNVLSNRPVNSYKFFFKSMDQDFGVVKEEVSD 65

Human    66 DNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDG 130
            ||||||||||||||||||||.:|:|..|..|||||:.|||||||||||||||||||.|..:||||
Zfish    66 DNAKLPCFNGRVVSWLVLAESSHTDGMSVCTDSHTEHPPPLERTGGIGDSRPPSFHANAVNSRDG 130

Human   131 MDNETGTESMVSHRRERAR---RRNREEAARTNGHPRGDR-RRDVGLPPDSASTALSSELESSSF 191
            :|.|||:|.::.|||||.|   ||.|::..|.|||.:.:| .||..:..||.| .:|||||||||
Zfish   131 LDTETGSEPVLRHRRERERERTRRRRDDFPRLNGHSKAERVVRDSAMGCDSGS-IMSSELESSSF 194

Human   192 VDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNM 256
            :||:::...||||||||||:|.:|:::||||||:.::.:.||:|||||||||||||||:||||||
Zfish   195 IDSEDEEDASRLSSSTEQSSSFQLMKRHKRRRRRHKVAKIDRSSSFSSITDSTMSLNIITVTLNM 259

Human   257 ERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVL 321
            |:::|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|
Zfish   260 EKYNFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRIL 324

Human   322 REIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAV 386
            |||||:.|||||||||||||:||||||:|||:||||||||||:|||.||||:.|:.||      |
Zfish   325 REIVSKNGPISLTVAKCWDPSPRSYFTIPRAEPVRPIDPAAWISHTTALTGSYPQNGT------V 383

Human   387 TRTSSSSLTSSVPG-------APQLEEAPLTV-KSDMSAVVRVMQLPDSGLEIRDRMWLKITIAN 443
            ...:...:.|:|..       ..:.:|.|||: |:||:.:|:|||||||||||||||||||||||
Zfish   384 FLVTDDCMFSAVKHDLILPLFFTEFDELPLTMGKTDMATIVKVMQLPDSGLEIRDRMWLKITIAN 448

Human   444 AVIGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLN 508
            ||||.|||||||:.|||||:||:||||||||||||:||||||||||||||||.|||||.|:||||
Zfish   449 AVIGGDVVDWLYSRVEGFKDRRDARKYASSLLKHGYLRHTVNKITFSEQCYYTFGDLCQNMATLN 513

Human   509 LNSGSSGT-SDQDTLAPLPHPAA-PWPLGQGYPYQYP--GPPPCFPPAYQDPGFSYGSGSTGSQQ 569
            ||.||||. |:||||||||.|:. |||:| |.|:.||  ..||.|||.|.||..|:.|||.||..
Zfish   514 LNEGSSGAGSEQDTLAPLPPPSTNPWPMG-GQPFPYPPFTAPPAFPPGYSDPCHSFHSGSAGSHH 577

Human   570 SEGSKSSGSTRS---SRRAPGREKERRAAGAGGSGSESDHTAPSGVGSSWR--ERPAGQLSRGS- 628
            ||||:||.|..|   .:||..|||||::     :|||||    ||..:..|  ||.|.|||..|
Zfish   578 SEGSRSSSSNPSIGRIQRAVPREKERKS-----TGSESD----SGKRAGGRRVERSASQLSHRSH 633

Human   629 --------------------------------------SPRSQASATA-PGLPPPHP---TTKAY 651
                                                  |.||.||:.. ||||||:.   .|...
Zfish   634 ALSSRSHTHSRVPSQHSRTSFSYSHAPFTKYGHTSCALSERSHASSYGPPGLPPPYSLARLTPKG 698

Human   652 TVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM 695
            .|..||||.|||||:.|:|||||.||||||.|||||||||||||
Zfish   699 AVCSGPPGAPPVREMGAIPPELTASRQSFQHAMGNPCEFFVDIM 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DVL1	NP_001317240.1	DAX	1..85	CDD:197474	76/83 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	89..237		87/151 (58%)
		Dishevelled	90..247	CDD:460544	97/160 (61%)
		PDZ_Dishevelled-like	251..337	CDD:467201	79/85 (93%)
		DEP_dishevelled	417..499	CDD:239885	71/81 (88%)
		Dsh_C	503..685	CDD:463531	108/233 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..667		67/173 (39%)
dvl1b	XP_005169354.2	None