Protein Alignment DVL1 and dsh-2

DIOPT Version :10

• Sequence 1: NP_001317240.1
• Gene: DVL1 / 1855
• HGNCID: 3084
• Length: 695
• Species: Homo sapiens
• Sequence 2: NP_494937.4
• Gene: dsh-2 / 266854
• WormBaseID: WBGene00001102
• Length: 759
• Species: Caenorhabditis elegans
• Alignment Length: 751
• Identity: 221/751 - (29%)
• Similarity: 342/751 - (45%)
• Gaps: 157/751 - (20%)

Human     4 TKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGV-VKEEIFDDN 67
            ||:..|:|::|.||:|::.|.|:.:||.|.|..|...   .:|::..::|.|.|: ||.|:.||:
 Worm   104 TKVYCHLDDQEHPYMVEVHVPPDCITLRDVKRKLMRT---NFKYYCIALDPDTGLEVKAEVRDDS 165

Human    68 AKL-PCFNGRVVSWLVLAEGA-HSDA--------------GSQGTDS------HTDLPPPLERTG 110
            .:| |..|||...:|:..||: |||.              ||.|:..      |.|.|.|..
 Worm   166 RRLYPLKNGRFELYLLTVEGSVHSDTSSGRHRRKQDGSSKGSSGSREYLRAAHHYDNPTPFS--- 227

Human   111 GIGDSRPPSFHPNVASSRDGMDNETGTESMVSH--------RRERARRRNREEAARTNGHPRGDR 167
              .|....|..|.........:.:...::...|        |....|:.:.||:.........|.
 Worm   228 --DDESQASSLPTYVKKAHAYNRKHAPQAYERHLPHMKHNNRHNHHRQNHYEESTFDVTTESDDH 290

Human   168 RRDVGLPPDSASTALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQ-- 230
            .||                 ..::.|.|||.|.   |.:|:.::.|::..|.|.|::::.:|.
 Worm   291 YRD-----------------GVTYYDEDEDDSR---SINTDLTSVSQVHLKQKWRQQQKEMRNKW 335

Human   231 ------ADRASSFSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAV 289
                  :..:|||||||:|:|.|.::||.||:|... ||::..|.:|.|||.|:|:|.|...|||
 Worm   336 KRMPSISTASSSFSSITESSMGLEVITVRLNLETIP-LGMTPSGHTNARGDAGLYVGDIQDRGAV 399

Human   290 AADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADP 354
            |.||||:.|||::.:|:::..|.||.:||::|||.| |...::||:||..||...::...|||:|
 Worm   400 ALDGRIDIGDMIVGINEISLGNYSNKEAVQLLREAV-QRQYLTLTIAKTGDPKQNAFPRNPRAEP 463

Human   355 VRPIDPAAWLSHTAALTGALPRYGTSPCSSAVTRTSSSS-------LTSSVPGAPQLEEAP---L 409
            :|||||..|:.|......|:|         :::..|||:       ..||..|.|.....|   |
 Worm   464 IRPIDPNEWVKHATNAMKAMP---------SISEESSSTPIPDDWPTNSSASGTPFGGPPPANCL 519

Human   410 TVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSL 474
            .|.:|...||.||..|.|||:|:||.|.||.|..:.:|.|:|:||..||:|.:.:::||::|..:
 Worm   520 NVMTDKKYVVEVMAAPGSGLDIKDRYWFKIPIPMSFLGTDLVEWLVKHVQGLETKKKAREFAEEM 584

Human   475 LKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQGYP 539
            ||.|::|..|.|.:|:::||||.||.|::...|.
 Worm   585 LKLGYIRPGVGKQSFTKECYYVMGDECADYTQLR------------------------------- 618

Human   540 YQYPGPPPCFPPAYQDPGFSYGSGSTGSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSGSES 604
                ||         |.|:.|       .||..|.:||.:.::...|......:...||.....:
 Worm   619 ----GP---------DGGYKY-------PQSHASSASGHSSNNLIFPPSMYPPQPPTAGAVHHRN 663

Human   605 DHTAPSGVGSSWRERPAGQLSRGSS-----------PRSQASATAPGLPPPHPTTKAYTVVGGPP 658
            ....||.:...:...||.....|.:           .|||||.::.|      :::.|..:...|
 Worm   664 SVILPSSMTGGYASLPASPFPHGKASVNDCRRTRDDQRSQASGSSRG------SSRRYVELPRKP 722

Human   659 GGPPVRELAAVPPELTGSRQSFQKAM-GNPCEFFVD 693
            .........||..:...||.||:.|| |:..:|.:|
 Worm   723 ASLSSGSGLAVDLDRVASRSSFRAAMNGSHPQFNID 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DVL1	NP_001317240.1	DAX	1..85	CDD:197474	30/82 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	89..237		33/183 (18%)
		Dishevelled	90..247	CDD:460544	40/192 (21%)
		PDZ_Dishevelled-like	251..337	CDD:467201	40/85 (47%)
		DEP_dishevelled	417..499	CDD:239885	37/81 (46%)
		Dsh_C	503..685	CDD:463531	35/193 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..667		26/134 (19%)
dsh-2	NP_494937.4	DAX	101..184	CDD:197474	30/82 (37%)
		PDZ_Dishevelled-like	362..446	CDD:467201	40/85 (47%)
		DEP_dishevelled	528..609	CDD:239885	37/80 (46%)