DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pcsk1 and Fur2

DIOPT Version :9

Sequence 1:NP_038656.1 Gene:Pcsk1 / 18548 MGIID:97511 Length:753 Species:Mus musculus
Sequence 2:NP_727963.1 Gene:Fur2 / 32604 FlyBaseID:FBgn0004598 Length:1682 Species:Drosophila melanogaster


Alignment Length:641 Identity:299/641 - (46%)
Similarity:400/641 - (62%) Gaps:60/641 - (9%)


- Green bases have known domain annotations that are detailed below.


Mouse    24 SVKAKRQFVNEWAAEIPGGQEAASAIAEELGYDLLGQIGSLENHYLFKHKSHPRRSRRSALHITK 88
            |:..:..:.||:|..||.|::.|..||.:.|:...||||||:|:|||:|....:||.||:.....
  Fly   232 SIPEEAIYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQG 296

Mouse    89 RLSDDDRVTWAEQQYEKERSKRS----------------------VQKDSALD------------ 119
            .|..::.|.|.:||:||.|.||.                      |..:..|.            
  Fly   297 ALKSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHS 361

Mouse   120 ------------LFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWEKGITGKGVVITVLDDGLEW 172
                        :|.||::.:||||. ::...|...||::|.|.|:||.||||||:::||||::.
  Fly   362 QRMEYRDVSSHFIFPDPLFKEQWYLV-SKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQT 425

Mouse   173 NHTDIYANYDPEASYDFNDNDHDPFPRYDLTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGG 237
            ||.|:..|||||||:|.|.||.||.|:.:  .:||||||||||:|..|.|:.||||||||:.:||
  Fly   426 NHPDLAQNYDPEASFDINGNDSDPTPQDN--GDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGG 488

Mouse   238 IRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSI 302
            :|||||.|.|.:||.::..||.|:|||||||||.|||.||:|||.||::||.|||..||||||||
  Fly   489 VRMLDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSI 553

Mouse   303 FVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSG-DYTDQRIT 366
            ||||||||||..|:|:|||||:||:|:|||||:|.|..|||.|:|||||||:|||| ...|:.:.
  Fly   554 FVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVA 618

Mouse   367 SADLHND------CTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLASNPG 425
            :.|:...      ||..||||||||||||||.||||||||.|||||||:|||:||...||....|
  Fly   619 TVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENG 683

Mouse   426 WKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRNVPEKKECVVKDNNFEPRALKANGEVI-VEI 489
            |..||.....:.:||:||::|.|:|.||:  .|.:||.:..|..::||.:.:...|.|..: ..:
  Fly   684 WTLNGVKRKYSHKFGYGLMDAGAMVSLAE--QWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHM 746

Mouse   490 PTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAVGTSTVLLAERERDTSPNGFKNWDFM 554
            ....|.|..|.::.|||||...|:.:..||:|.:.|||.:||::.||.||.||...:.|.:|.|:
  Fly   747 DVNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFL 811

Mouse   555 SVHTWGENPVGTWTLKITDMSGRMQNE-GRIVNWKLILHGTSSQPEHMKQPRVYTS 609
            |||.|||...|.|||::.:...|..|: |.:..|:||.:|||:||..:|...:.:|
  Fly   812 SVHFWGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSS 867

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pcsk1NP_038656.1 S8_pro-domain 34..110 CDD:374560 32/75 (43%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 121..415 CDD:173789 187/300 (62%)
P_proprotein 504..591 CDD:366670 38/87 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 633..663
Proho_convert 715..751 CDD:371942
Fur2NP_727963.1 S8_pro-domain 242..318 CDD:293079 32/75 (43%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-like 375..674 CDD:173789 188/301 (62%)
Peptidase_S8 411..700 CDD:278510 181/290 (62%)
P_proprotein 761..849 CDD:279782 38/87 (44%)
Furin-like 966..1126 CDD:279142
FU 970..1013 CDD:238021
FU 1017..1067 CDD:238021
FU 1063..1106 CDD:214589
GF_recep_IV 1068..1232 CDD:291509
FU 1116..1163 CDD:238021
FU 1211..1255 CDD:214589
FU 1259..1301 CDD:214589
FU 1304..1348 CDD:214589
FU 1356..1403 CDD:238021
FU 1401..1444 CDD:214589
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1404
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D311719at33208
OrthoFinder 1 1.000 - - FOG0000204
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100362
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.720

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