DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pax9 and Poxm

DIOPT Version :9

Sequence 1:	NP_035171.1	Gene:	Pax9 / 18511	MGIID:	97493	Length:	342	Species:	Mus musculus
Sequence 2:	NP_001036687.1	Gene:	Poxm / 40990	FlyBaseID:	FBgn0003129	Length:	370	Species:	Drosophila melanogaster

Alignment Length:	403	Identity:	168/403 - (41%)
Similarity:	196/403 - (48%)	Gaps:	134/403 - (33%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 PAFGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSIL 67
            |.:|||||||||||||||||||.|:||||||:||||||||||||||||||||||||||:||||||
  Fly     8 PQYGEVNQLGGVFVNGRPLPNATRMRIVELARLGIRPCDISRQLRVSHGCVSKILARYHETGSIL 72

Mouse    68 PGAIGGSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIG 132
            ||||||||||||||.||.:||..|||||||||||||||||::|:|||.|||||||||||||||:|
  Fly    73 PGAIGGSKPRVTTPKVVNYIRELKQRDPGIFAWEIRDRLLSEGICDKTNVPSVSSISRILRNKLG 137

Mouse   133 NLAQQ---------------------------------------------GHYDSYKQHQPAPQP 152
            :|..|                                             .|:..:..|..:...
  Fly   138 SLGHQHTPGTVMGSGSSSGGGSVSSNGGQNNGTSASNNINLSNLGNPGGGPHHPHHHHHHQSAAA 202

Mouse   153 ALPYNHIYSYP-----------SPITAAAA-KVPTPPGVPAIP------GSVALPRT-------- 191
            |...:|::::.           .|.:|||| .:.||.|.|:.|      |||..|..
  Fly   203 AASAHHVHAHAHAHAHLYNSIYQPYSAAAAYSMKTPCGSPSPPQGAGGQGSVPHPHQLRSVAAAA 267

Mouse   192 ----WPSSHSVTDILGIRSITDQGVSDSSPYHSPKVEEWSSLGRNNFPAAAPHAVNGLEKGALEQ 252
                |||||||:|||.               |...|                         ||..
  Fly   268 AAAHWPSSHSVSDILA---------------HHQAV-------------------------ALRA 292

Mouse   253 EAKYGQAPNGLPAVSSFVSASSMAPYPT---------------PAQVSPYMTYSAAPSGYVAGH- 301
            ..:.|....|:..:.|.||...|.|.|.               ..|.|||..|....:|.:..|
  Fly   293 SCQVGVGVGGMGGMGSTVSPLPMTPSPVAGTAGGQPLLDCEGGAGQQSPYNYYMYFQNGGMHHHH 357

Mouse   302 ---GWQHAGSTPL 311
               |...||:|.|
  Fly   358 HHGGMMAAGATGL 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax9	NP_035171.1	PAX	6..131	CDD:238076	111/124 (90%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	7..63		51/55 (93%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	82..130		38/47 (81%)
		Interaction with KDM5B. /evidence=ECO:0000250	168..189		12/27 (44%)
Poxm	NP_001036687.1	PAX	10..133	CDD:128645	108/122 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	225	1.000	Domainoid score	I2523
eggNOG	1	0.900	-	-		E1_KOG3517
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3248
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1339212at2759
OrthoFinder	1	1.000	-	-		FOG0003351
OrthoInspector	1	1.000	-	-		otm42840
orthoMCL	1	0.900	-	-		OOG6_106145
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3849
SonicParanoid	1	1.000	-	-		X2237
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860