Protein Alignment Pax8 and toy

DIOPT Version :10

• Sequence 1: NP_035170.1
• Gene: Pax8 / 18510
• MGIID: 97492
• Length: 457
• Species: Mus musculus
• Sequence 2: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Alignment Length: 533
• Identity: 181/533 - (33%)
• Similarity: 246/533 - (46%)
• Gaps: 135/533 - (25%)

Mouse     2 PHNSI---------RSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGC 57
            ||:|:         .:||.|:|||||.:|||||||:..||:||:|||.|.|||||||.|:||:||
  Fly    13 PHSSVGQSTLFGCSTAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGC 77

Mouse    58 VSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTV 122
            ||||||||||||||:|..||||||:|||..||:||.||||:.|::||||||||||:|.||::|.:
  Fly    78 VSKILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNI 142

Mouse   123 PSVSSINRIIRT----KVQQP-------------FN--------LPMDSCVATKSLSPGHTLIPS 162
            ||||||||::|.    |.||.             ||        .|.::..|..:|.|.     :
  Fly   143 PSVSSINRVLRNLASQKEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLTLPPA-----A 202

Mouse   163 SAVTPPESPQSDSLGSTYSINGLLGIAQPGNDNKRKMDDSDQDSCRLSIDSQS------SSSG-- 219
            |.||.|.:              |.|.|...:..||::..|.:.|...|.||.|      :|||
  Fly   203 SVVTSPAN--------------LSGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGDE 253

Mouse   220 --------PRKHLRTDT-FSQHHLEALECPFERQHYPEAYA-------------------SPSHT 256
                    .||..|..| ||...:::||..|||.|||:.:|                   |....
  Fly   254 DSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRA 318

Mouse   257 KGEQGLYPLPLLNSA-LDDGKATLTSSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPELSSSSS 320
            |..:.........|| ..||....:::|.|.|...|:           |.......||.:.:|:.
  Fly   319 KWRREEKMRTQRRSADTVDGSGRTSTANNPSGTTASS-----------SVATSNNSTPGIVNSAI 372

Mouse   321 TPSSLSSSAFLDLQQVGSGGPAGASVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHI 385
            ..:..:|||.:.                 |:.|.|::......|:|..:......|.|....|.:
  Fly   373 NVAERTSSALVS-----------------NSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRL 420

Mouse   386 PTSGQGSYASSAIAGMVA--GSEYSGNAYSHTP-----YSSYSEAWRFPNSSLLSSPY----YYS 439
            |.:...:...|:|...:|  ...|:.:..|.||     ..:|...:..|.|  |.|||    :.:
  Fly   421 PLNSGFNTMYSSIPQPIATMAENYNSSLGSMTPSCLQQRDAYPYMFHDPLS--LGSPYVSAHHRN 483

Mouse   440 STSRPSA----PP 448
            :...|||    ||
  Fly   484 TACNPSAAHQQPP 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pax8	NP_035170.1	PAX	9..133	CDD:128645	90/123 (73%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		42/55 (76%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		32/51 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..224		20/80 (25%)
		Pax2_C	344..456	CDD:463563	28/120 (23%)
toy	NP_001368990.1	PAX	29..153	CDD:128645	90/123 (73%)
		COG5576	<253..368	CDD:227863	28/125 (22%)
		Homeodomain	267..322	CDD:459649	15/54 (28%)