Protein Alignment Pax8 and sv

DIOPT Version :10

• Sequence 1: NP_035170.1
• Gene: Pax8 / 18510
• MGIID: 97492
• Length: 457
• Species: Mus musculus
• Sequence 2: NP_524633.3
• Gene: sv / 43825
• FlyBaseID: FBgn0005561
• Length: 844
• Species: Drosophila melanogaster
• Alignment Length: 665
• Identity: 207/665 - (31%)
• Similarity: 268/665 - (40%)
• Gaps: 248/665 - (37%)

Mouse     3 HNSIRS----GHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILG 63
            |:|..|    ||||:|||||.||||||||:|||||||:|||.||||||||||||||||||||||.
  Fly   165 HSSQGSISGDGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVSKILS 229

Mouse    64 RYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSI 128
            |||||||.:.|||||||||||||.||:.|.:|||:||||||||||||||||.:|..|.|||||||
  Fly   230 RYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEAICSQDNVPSVSSI 294

Mouse   129 NRIIRTKV----------QQPFNLPMDSCVATKSLSPGHTLIPS-----SAVTPPESPQSDS--- 175
            |||:|.|.          ||..        .::||..||....|     ..:..|:.|.|:|
  Fly   295 NRIVRNKAAEKAKHVHHHQQHH--------VSQSLGGGHIATESVDSSTGTIGEPQPPTSNSSAN 351

Mouse   176 ----------------------------------------LGST-------YSINGLLGIAQPG- 192
                                                    :.||       |||||:||| |.|
  Fly   352 SVNTNVSASASVHASIPTSGTDSVQVSVGHINANSNETTHINSTAEQRTTGYSINGILGI-QHGH 415

Mouse   193 ----NDNKRKMDDSD--QDSC-RLSIDSQS--------SSSGPRKHLRTDTFS------------ 230
                |:|...:::::  :.|| |..|::..        |.:...|..|..|:|
  Fly   416 HSHNNNNNSSVNNNNNTESSCKRKRIEAHDENHDTNIHSDNDDGKRQRMSTYSGDQLYTNIWSGK 480

Mouse   231 -----QHHLEAL---------ECPFERQHYPEA------------------------YASPSHTK 257
                 .|.|.|.         .||   ..|.||                        |.|.:...
  Fly   481 WCIKDDHKLLAELGNLTASTGNCP---ATYYEASNGFSTTPISGSGATASGNDTSMLYDSITTIS 542

Mouse   258 GEQGLYPLPLLNSALDDGKAT----LTSSNTPLGRNLSTHQTYP--------------------- 297
            ..|.....|.:..::..|..|    ::.....|..|....||.|
  Fly   543 QTQSSIYTPAIGPSIGTGSLTPLVPISMHEMKLSANSIQEQTVPPFYTALAFDGNYTSMTSLENC 607

Mouse   298 --VVADPH--SPFAIKQET---------PELSSSSST-------------------PSSLSSSAF 330
              :|...|  .|.:....|         |:::.::||                   |...:||..
  Fly   608 SSLVGQEHIVMPESSDSNTLCPISTRIVPDITETNSTRVKEPLTNSDGCSEDNNKEPEKSNSSQS 672

Mouse   331 LD------LQQVGSGGPAGASVPPFNAFPHAASVY-----GQFTGQALLSGREMVGPT------- 377
            .|      |..:|.....|......||..|.:|:.     |   |.:||:    :.|:
  Fly   673 SDHIASPHLHHIGEEQLRGNRRSNLNASTHPSSLIPLQPSG---GSSLLN----INPSENRSDVE 730

Mouse   378 --------LPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGN-AYSH--TPYSSYSEAWRFPNSSL 431
                    |...|..:|:.   ::.|:..:.:|.||:|:.| ||:.  ..|.||...   ..|.|
  Fly   731 LNLSNNVGLYSTPTVLPSF---NHYSAGCSSVVPGSDYAYNPAYTQYGGAYGSYGYG---TGSGL 789

Mouse   432 LSSPYYYSS--TSRP 444
            ::|.|||.|  |..|
  Fly   790 INSSYYYESGQTQSP 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pax8	NP_035170.1	PAX	9..133	CDD:128645	103/123 (84%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		49/55 (89%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		35/47 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..224		25/135 (19%)
		Pax2_C	344..456	CDD:463563	32/126 (25%)
sv	NP_524633.3	PAX	175..299	CDD:128645	103/123 (84%)