Protein Alignment Pax8 and gsb

DIOPT Version :10

• Sequence 1: NP_035170.1
• Gene: Pax8 / 18510
• MGIID: 97492
• Length: 457
• Species: Mus musculus
• Sequence 2: NP_523863.1
• Gene: gsb / 38005
• FlyBaseID: FBgn0001148
• Length: 427
• Species: Drosophila melanogaster
• Alignment Length: 489
• Identity: 155/489 - (31%)
• Similarity: 220/489 - (44%)
• Gaps: 131/489 - (26%)

Mouse     9 GHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRP 73
            |.|.:|||||.|:||||||..:|::||::|..|||||.||||||||||||||||.|:.|||||||
  Fly    19 GQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQLRVSHGCVSKILNRFQETGSIRP 83

Mouse    74 GVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQ 138
            ||||||||:||||.:..:|.:.|:..|.:|:||||.:|:..||||....||||||:|::|
  Fly    84 GVIGGSKPRVATPDIESRIEELKQSQPGIFSWEIRAKLIEAGVCDKQNAPSVSSISRLLR----- 143

Mouse   139 PFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQPGNDNKRKMDDSD 203
                                             .|...|:::||:|:||    |.......:|..
  Fly   144 ---------------------------------GSSGSGTSHSIDGILG----GGAGSVGSEDES 171

Mouse   204 QDSCRLSIDSQSSSSGPRKHLRT-DTFSQHHLEALECPFERQHYPEAYASP-------------- 253
            :|      |::.|....||..|: .|||...::|||..|.|..||:.|...
  Fly   172 ED------DAEPSVQLKRKQRRSRTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQ 230

Mouse   254 -------SHTKGEQGLYPLPLLNSALDDGKATLTSSNTP---LGRNLSTHQTYPV--VADPHSPF 306
                   :..:.:.....:|..........||.|:|..|   :|.:|.:.|::|.  ..:.|:.:
  Fly   231 VWFSNRRARLRKQLNTQQVPSFAPTSTSFGATPTTSAAPAPNMGMSLYSSQSWPSSGAYENHAAY 295

Mouse   307 --AIKQETPELSSSSSTPSSLSSSAFLDLQQVGSGGPAGASVPPFNAFPHAASVYGQFTGQALLS 369
              ::...:| .||:|.|.|:..|......||.|:|.            ....|.||
  Fly   296 GGSVASMSP-ASSTSGTSSAAHSPVQTQAQQPGTGS------------EFMTSTYG--------- 338

Mouse   370 GREMVGPTLPGYP------PHIPTSG----QGSYASSAIAGMVAGSEYSGNAYSHTP--YSSYSE 422
                ||.:...||      |..|.:.    :..:||:|.:|            ||.|  :.||:.
  Fly   339 ----VGSSNATYPSAAYSMPQTPATSAEQLRSQFASAAASG------------SHHPSTWDSYNF 387

Mouse   423 AWR-FPNSSLLS---SPYYYSSTSRPSAPPTSAT 452
            |.. ||.:|...   |.|::....:.|...|:.|
  Fly   388 AGSFFPPASAAGNHISGYHHQVDQKSSMMTTAPT 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pax8	NP_035170.1	PAX	9..133	CDD:128645	79/123 (64%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		38/55 (69%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		21/47 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..224		14/64 (22%)
		Pax2_C	344..456	CDD:463563	27/125 (22%)
gsb	NP_523863.1	PAX	19..143	CDD:128645	79/123 (64%)
		Homeodomain	186..242	CDD:459649	12/55 (22%)