DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pax8 and gsb-n

DIOPT Version :9

Sequence 1:	NP_035170.1	Gene:	Pax8 / 18510	MGIID:	97492	Length:	457	Species:	Mus musculus
Sequence 2:	NP_523862.1	Gene:	gsb-n / 38004	FlyBaseID:	FBgn0001147	Length:	449	Species:	Drosophila melanogaster

Alignment Length:	430	Identity:	148/430 - (34%)
Similarity:	199/430 - (46%)	Gaps:	131/430 - (30%)

- Green bases have known domain annotations that are detailed below.

Mouse     4 NSIR--------SGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSK 60
            ||:|        .|.|.:|||||.|:||||||..:|.:||::|..|||||.||||||||||||||
  Fly     7 NSLRPLFAGYPFQGQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSK 71

Mouse    61 ILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSV 125
            ||.||.|||||||||||||||||.:|::..:|.:.:::||::|:||||::|:.||..|   .||.
  Fly    72 ILNRYQETGSIRPGVIGGSKPKVTSPEIETRIDELRKENPSIFSWEIREKLIKEGFAD---PPST 133

Mouse   126 SSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLIPSSAVTPPESPQSDSLGSTYSINGLLGIAQ 190
            |||:|::|                             .:....|..:.|     |:|||:||
  Fly   134 SSISRLLR-----------------------------GSDRGSEDGRKD-----YTINGILG--- 161

Mouse   191 PGNDNKRKMDDSDQDSCRLSIDSQSSSSGPRKHLRT-DTFSQHHLEALECPFERQHYPEAYASPS 254
             |.|:    |.||       .:|:......||..|: .||:...|||||..|.|..||:.|
  Fly   162 -GRDS----DISD-------TESEPGIPLKRKQRRSRTTFTAEQLEALERAFSRTQYPDVY---- 210

Mouse   255 HTKGEQGLYPLPLLNSALDDGKATLTSSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPELSSSS 319
             |:.|..      ..:||.:.:..:..||.  ...|..|...                   |:|.
  Fly   211 -TREELA------QTTALTEARIQVWFSNR--RARLRKHSGG-------------------SNSG 247

Mouse   320 STPSSLSSSAFLDLQQVGSG-GPAGASVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPP 383
            .:|.:..||      .||.| |.:||:.|                   |..|...|| ::.||.|
  Fly   248 LSPMNSGSS------NVGVGVGLSGATAP-------------------LGYGPLGVG-SMAGYSP 286

Mouse   384 HIPTSGQGSYASSAIAGMVAGSEYSGNAYSHTPYSSYSEA 423
            ...|:..|       |||..|..::    :|.|.|.:|.|
  Fly   287 APGTTATG-------AGMNDGVHHA----AHAPSSHHSAA 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pax8	NP_035170.1	PAX	9..133	CDD:128645	77/123 (63%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	12..68		39/55 (71%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	87..135		19/47 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..224		16/64 (25%)
		Pax2_C	344..455	CDD:372091	20/80 (25%)
gsb-n	NP_523862.1	PAX	20..141	CDD:278709	77/123 (63%)
gsb-n	NP_523862.1	Homeobox	185..238	CDD:278475	18/65 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810